The role of metabolic syndrome factors on cognition using latent variable modeling: The neurocognitive study on aging

Philippou, Elena; Michaelides, Michalis P.; Constantinidou, Fofi

doi:10.1080/13803395.2018.1483487

Cited by 16 publications

(19 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This significant interaction was observed despite the fact that the association between education and EF, diminished across time. Previous research with our cohort analyzing baseline performance (Constantinidou et al, 2012a;Giogkaraki et al, 2013;Constantinidou et al, 2015;Philippou et al, 2018) demonstrated that younger participants and those with higher levels of education performed better as compared to older participants and those with lower levels of education on VEM and EF measures. Furthermore, cognitive reserve moderated the effects of biological age on VEM and EF, however, the moderating effect was higher for EF at baseline (Giogkaraki et al, 2013).…”

Section: Demographic Factors Of Age and Education And Cognitive Changementioning

confidence: 71%

“…Study participants were community dwellers living independently, who were born and raised in a small Mediterranean country with its unique geopolitical, social-cultural and genetic characteristics. As noted in previous publications stemming from NEUROAGE ( Constantinidou et al, 2012a ; Philippou et al, 2018 ), the project has been able to capture the last generation of Cypriots who have attended very little formal schooling. While the average education is 9 years, there was a wide variability among study participants, ranging from 2–20 years.…”

Section: Discussionmentioning

confidence: 99%

“…Hopkins Verbal Learning Test–Revised (Greek version; HVLT; Benedict et al, 1998 ); adapted in Greek by Constantinidou upon permission by the publisher ( Constantinidou et al, 2015 ; Philippou et al, 2018 ). Learning trials (first trial and the total score of the three trials), delayed recall and delayed recall performance scores were used.…”

Section: Methodsmentioning

confidence: 99%

“…• Hopkins Verbal Learning Test-Revised (Greek version; HVLT; Benedict et al, 1998); adapted in Greek by Constantinidou upon permission by the publisher (Constantinidou et al, 2015;Philippou et al, 2018).…”

Section: Verbal Episodic Memorymentioning

confidence: 99%

See 3 more Smart Citations

The Neurocognitive Study for the Aging: Longitudinal Analysis on the Contribution of Sex, Age, Education and APOE ɛ4 on Cognitive Performance

et al. 2021

Self Cite

View full text Add to dashboard Cite

Objective: The effects of normal cognitive aging on executive functions (EF), Verbal Episodic Memory (VEM) and the contribution of age, sex, education, and APOΕ ε4 in a group of old Greek Cypriots across a five-year period were investigated.Design: NEUROAGE, the first project on cognitive aging in Cyprus, is a prospective longitudinal study with a rolling admission process. Participants are assessed at baseline and retested every 24–30 months.Subjects: 170 participants completed all three testing cycles; 86 men and 84 women with ages ranging between 60 and 88 years (mean = 73.21, SD = 5.84); education, 2–20 years (mean = 9.07, SD = 4.27).Results: Α Repeated Measures Multivariate Analysis of Covariance was conducted with one between-subject factor: sex; two covariates: age and education, while Time (time 1, time 2, time 3) served as a within – subject factor. Time did not have an effect on mini mental status examination in Greek (MMSE), EF or VEM. Also, sex had no effect on MMSE, EF and VEM. There was no time by sex interaction. Age and Education significantly predicted the EF performance, F(1, 168) = 11.23, p < 0.05; F(1, 158) = 90.03, p < 0.001 and VEM performance, F(1, 171) = 17.22, p < 0.001; F(1, 171) = 61.25, p < 0.001. Furthermore, there was a significant interaction effect between time and education, for EF, F(2, 167) = 7.02, p < 0.001. Performance of the APOE ε4 carriers did not differ on any of the above measures as compared to performance of non-carriers in this older adult group.Conclusion: Cognitively healthy adults maintained overall cognitive performance across the five-year period. Male and female participants performed similarly and the pattern of change over time was similar across the two sexes. Education was predictive of VEM and EF performance across time. Furthermore, those with higher education maintained higher levels of EF performance. APOE results did not differentiate performance at baseline. Implications of findings are discussed.

show abstract

Section: Demographic Factors Of Age and Education And Cognitive Changementioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Verbal Episodic Memorymentioning

confidence: 99%

See 2 more Smart Citations

The Neurocognitive Study for the Aging: Longitudinal Analysis on the Contribution of Sex, Age, Education and APOE ɛ4 on Cognitive Performance

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…In this view, recent literature suggested a role of metabolic syndrome (MetS). MetS, consisting of a set of cardio-metabolic alterations, has been shown to increase the risk of cognitive decline in the general population, probably because of its effect on cerebral circulation (15–18). This issue of MetS is particularly relevant in patients with schizophrenia, also because of its increased prevalence in this population (19, 20).…”

Section: Introductionmentioning

confidence: 99%

Improving Cognition to Increase Treatment Efficacy in Schizophrenia: Effects of Metabolic Syndrome on Cognitive Remediation's Outcome

et al. 2018

View full text Add to dashboard Cite

Cognitive impairment, typically more severe in treatment resistant patients, is considered a hallmark of schizophrenia and the prime driver of functional disability. Recent evidence suggests that metabolic syndrome may contribute to cognitive deficits in schizophrenia, possibly through shared underlying mechanisms. However, results are still contradictory and no study has so far examined the influence of metabolic syndrome on cognitive outcome after cognitive remediation therapy (CRT). Based on these premises, this study aims to investigate the relationship between metabolic syndrome and cognition, specifically considering cognitive outcome after treatment. Secondary objectives include the analysis of the association between cognitive impairment and psychopathological status and, in a subgroup of patients, the evaluation of the effect of Sterol Regulatory Element Binding Transcription Factor 1 (SREBF-1) rs11868035 genetic polymorphism, previously associated with metabolic alterations, on both cognition and metabolic syndrome. One-hundred seventy-two outpatients with schizophrenia were assessed for metabolic parameters and neurocognitive measures and 138 patients, who completed CRT, were re-evaluated for cognition. A subsample of 51 patients was also genotyped for rs11868035 from peripheral blood sample. Results show a negative impact of metabolic syndrome on executive functions and global cognitive outcome after CRT. Data also revealed a significant effect of SREBF-1 polymorphism, with a higher prevalence of metabolic syndrome and worse processing speed performance among G/G homozygous subjects, compared the A allele carriers. Overall these findings support the hypothesis that metabolic alterations may hamper the capacity to restore cognitive deficits, as well as they highlight the need to further explore possible converging mechanisms underlying both cognitive and metabolic dysfunction. At the clinical level, results point to the importance of a comprehensive assessment including the metabolic status of patients and of individualized strategies addressing metabolic dysfunction in order to potentiate treatment outcome in schizophrenia.

show abstract

Coenzyme Q10 and Metabolic Syndrome

Hernández-Camacho

2020

Coenzyme Q in Aging

View full text Add to dashboard Cite

Metabolic syndrome (MS) has become a global health issue due to affect a high percentage of people in most of the countries. MS can be defined as the presence of three of the following factors: obesity, high triglyceride and cholesterol levels, low HDL cholesterol, high blood pressure or high fasting plasma glucose. All these factors increase the risk of cardiovascular disease, diabetes type II, some kind of cancers, sleep abnormalities or physical incapacity among others. Several factors have been identified in the aetiology of MS such as dietary patterns, sedentary lifestyle, genetic background, microbiota, socioeconomic status or age.Different treatments have been proposed for the treatment of MS, but, until today, there is no efficient solution. CoQ10 has emerged as a potential way in MS treatment endorsed by several clinical trials have shown improvements in lipid profile, glucose control, insulin homeostasis and hypertension control in MS patients. The molecular mechanism that could explain these improvements would be the antioxidant capacity of CoQ10 inhibiting oxidative stress that it is present in MS. Additionally, the proportion of CoQ10H2 could be also a crucial role in the protection again MS components. Furthermore, CoQ10 administration could be also helpful in the management of mitochondrial dysfunction associated to MS.

show abstract

The role of metabolic syndrome factors on cognition using latent variable modeling: The neurocognitive study on aging

Cited by 16 publications

References 46 publications

The Neurocognitive Study for the Aging: Longitudinal Analysis on the Contribution of Sex, Age, Education and APOE ɛ4 on Cognitive Performance

The Neurocognitive Study for the Aging: Longitudinal Analysis on the Contribution of Sex, Age, Education and APOE ɛ4 on Cognitive Performance

Improving Cognition to Increase Treatment Efficacy in Schizophrenia: Effects of Metabolic Syndrome on Cognitive Remediation's Outcome

Coenzyme Q10 and Metabolic Syndrome

Contact Info

Product

Resources

About