Rebuttal from Gregory D. Funk and Alexander V. Gourine

Funk, Gregory D.; Gourine, Alexander V.

doi:10.1113/jp276282

Cited by 7 publications

(14 citation statements)

References 15 publications

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“…While the initial increase indeed appears to be mediated by peripheral chemoreceptors, whether a central excitatory component helps shape the hypoxic ventilatory response during Phase 2 remains controversial and readers are referred to a recent Cross-Talk debate in the Journal of Physiology for a detailed discussion (Funk and Gourine, 2018a, b; Teppema, 2018a, b). Several points of consensus came from that Cross-Talk.…”

Section: Working Model Of Purinergic Signaling In the Prebötc Inspiramentioning

confidence: 99%

The Purinome and the preBötzinger Complex – A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response

Reklow

Alvares

Zhang

et al. 2019

Front. Cell. Neurosci.

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Exploration of purinergic signaling in brainstem homeostatic control processes is challenging the traditional view that the biphasic hypoxic ventilatory response, which comprises a rapid initial increase in breathing followed by a slower secondary depression, reflects the interaction between peripheral chemoreceptor-mediated excitation and central inhibition. While controversial, accumulating evidence supports that in addition to peripheral excitation, interactions between central excitatory and inhibitory purinergic mechanisms shape this key homeostatic reflex. The objective of this review is to present our working model of how purinergic signaling modulates the glutamatergic inspiratory synapse in the preBötzinger Complex (key site of inspiratory rhythm generation) to shape the hypoxic ventilatory response. It is based on the perspective that has emerged from decades of analysis of glutamatergic synapses in the hippocampus, where the actions of extracellular ATP are determined by a complex signaling system, the purinome. The purinome involves not only the actions of ATP and adenosine at P2 and P1 receptors, respectively, but diverse families of enzymes and transporters that collectively determine the rate of ATP degradation, adenosine accumulation and adenosine clearance. We summarize current knowledge of the roles played by these different purinergic elements in the hypoxic ventilatory response, often drawing on examples from other brain regions, and look ahead to many unanswered questions and remaining challenges.

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Section: Working Model Of Purinergic Signaling In the Prebötc Inspiramentioning

confidence: 99%

The Purinome and the preBötzinger Complex – A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response

Reklow

Alvares

Zhang

et al. 2019

Front. Cell. Neurosci.

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“…Above presented classic scheme of breathing autoregulation was queried recently [10,11]. Scientists dispute about adding one more element to the scheme (Figure 1) [4,5,[10][11][12].…”

Section: The Controversial Hypothesis Of Breathing Regulationmentioning

confidence: 99%

“…Above presented classic scheme of breathing autoregulation was queried recently [10,11]. Scientists dispute about adding one more element to the scheme (Figure 1) [4,5,[10][11][12]. Several authors [10,11] consider namely glial elements (astrocytes) in brain stem the key sensors to hypoxic stimulus [10,11], and not the neuronlike receptor elements responding to CO 2 shifts.…”

Section: The Controversial Hypothesis Of Breathing Regulationmentioning

confidence: 99%

Hypoxia and Hypercapnia: Sensory and Effector Mechanisms

Vladimir¹

2018

BJSTR

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“…Polish chemist Casimir Funk first isolated a bioactive substance from rice bran in 1912; featuring its eminence in curing diseases like scurvy, beriberi, pellagra for birds and human beings and coined the term “vitamin” for these substances [2–4]. Vitamin E was discovered by Herbert M. Evans and K. Scott Bishop in 1922 as a dietary constituent necessary for normal reproduction and a century yet to be passed since its discovery (1922‐2021*) [5].…”

Section: Introductionmentioning

confidence: 99%

A year away to 100th year of vitamin E synthesis

Kundu

Sarkar

2021

Journal of Heterocyclic Chem

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Vitamin E was discovered in the year 1922 as a dietary constituent by Herbert McLean Evans and Katharine J. Scott Bishop. Next year we will be celebrating 100th year anniversary of vitamin E discovery. This minireview highlights discoveries of eight naturally available forms (tocopherols and tocotrienols) of vitamin E and their most important synthetic attempts. This minireview is dedicated to the pioneers of vitamin E for serving a crucial biomolecule to the mankind.

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Rebuttal from Gregory D. Funk and Alexander V. Gourine

Cited by 7 publications

References 15 publications

The Purinome and the preBötzinger Complex – A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response

The Purinome and the preBötzinger Complex – A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response

Hypoxia and Hypercapnia: Sensory and Effector Mechanisms

A year away to 100th year of vitamin E synthesis

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