Characteristics and severity of preeclampsia in young and elderly gravidas with hypertensive disease

Rymer-Haskel, Noa; Schushan-Eisen, Irit; Hass, Yigal; Rahav, Roni; Maayan-Metzger, Ayala; Hendler, Israel

doi:10.1016/j.ejogrb.2018.05.038

Cited by 7 publications

(8 citation statements)

References 35 publications

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“…This was in accordance to many studies that identifies increased maternal age as a risk factor of preeclampsia (9) . Gaillard et al (10) mentioned that older age is related to the aging of uterine blood vessels and appears to be an independent obstetric risk factor for pre-eclampsia as it is associated with a gradual loss of vascular compliance, which subsequently leads to a higher afterload (10) .…”

Section: Discussionsupporting

confidence: 93%

Comparative Study of Mean Platelet Volume in Pre-eclampsia versus Normal Pregnancy in Third Trimester

Sheikhaq¹

2019

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Background: Pre-eclampsia is an obstetric condition that affects pregnant women and their fetuses. It is a leading cause of maternal and neonatal morbidity and mortality. Platelet activation and destruction is a well-recognized feature of pre-eclampsia, but the current literature is contradictory regarding the role of mean platelet volume (MPV) in the diagnosis of this condition. Objective: The aim of this study is to evaluate the mean platelet volume (MPV) as a method for diagnosis of preeclampsia by comparison between MPV in normal pregnancy and preeclampsia. Patients and Methods: The present study was a comparative case control study that was done during the

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Section: Discussionsupporting

confidence: 93%

Comparative Study of Mean Platelet Volume in Pre-eclampsia versus Normal Pregnancy in Third Trimester

Sheikhaq¹

2019

jmscr

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“…Obviously, once PE with severe features occurs among AMA patients, the risk of developing an AKI further increases, as endothelial injuries, which affect renal function dramatically, are more prominent [18,19]. Therefore, it is not surprising that we found even higher rates of AKIs in both the study and control groups compared to those in previous studies [14,15].…”

Section: Discussionmentioning

confidence: 56%

“…While several studies have documented an association between AMA and PE with severe features [4,8,9], there are limited data regarding the effect of maternal age on various characteristics of PE with severe features. Recently, Rymer-Haskel et al [14], in a retrospective case-control study, compared the prevalence of various clinical and laboratory parameters among patients with PE > 35 years old and patients < 35 years old. In agreement with our results, the authors showed that patients with PE > 35 years old had a higher risk of developing an AKI (15.2% vs. 4.3%, respectively).…”

Section: Discussionmentioning

confidence: 99%

The Association between Advanced Maternal Age and the Manifestations of Preeclampsia with Severe Features

Gilboa,

Kupferminc,

Schwartz

et al. 2023

JCM

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This retrospective cohort study aimed to explore the association between advanced maternal age and the clinical manifestations as well as laboratory parameters of preeclampsia with severe features. This study included 452 patients who were diagnosed with preeclampsia with severe features. The clinical and laboratorial characteristics of patients with preeclampsia with severe features aged ≥40 years old (study group) were compared to those of patients aged <40 years old (control group). Multivariant analysis was applied to assess the association between advanced maternal age and the manifestations of preeclampsia with severe features, adjusting for the variables that exhibited significant differences between the study and control groups. The multivariate analysis revealed that a maternal age of ≥40 years old was an independent risk factor for acute kidney injury (OR = 2.5, CI = 1.2–4.9, p = 0.011) and for new-onset postpartum preeclampsia (OR = 2.4, CI = 1.0–5.6, p = 0.046). Conversely, a maternal age ≥ 40 years old was associated with a reduced risk of HELLP syndrome (OR = 0.4, CI = 0.2–0.9, p = 0.018) and thrombocytopenia (OR = 0.5, CI = 0.3–0.9, p = 0.016) compared to that of the patients < 40 years of age. In conclusion, this study demonstrates that maternal age is significantly associated with the clinical manifestations and laboratory parameters of preeclampsia with severe features, highlighting the importance of age-specific management.

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“…Hipertensi pada ibu hamil mengakibatkan kerusakan jaringan secara terus menerus dan respon inflamasi menyebabkan vasospasme sistemik yang berakibat pada penurunan fungsi sistem organ dalam kasus preeklamsia. 7 Terdapat perbedaan kadar adipokin yang signifikan antara kelompok preeklamsia dan kelompok tanpa preeklamsia. Adiponektin, leptin, resistin, dan visfatin diidentifikasi sebagai prediktor signifikan preeklamsia.…”

Section: Pembahasanunclassified

Hubungan Antara Neutrophil Gelatinase Associated Lipocaline (NGAL) dan Kejadian Preeklamsia: Penelitian Potong-Lintang

Koesuma,

Lukas,

Tahir

et al. 2023

Obgynia

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Untuk mengetahui hubungan antara kadar Neutrophil Gelatinase Associated Lipocaline (NGAL) pada kehamilan normal, Preeklamsia Berat (PEB) tanpa Komplikasi, dan PEB dengan Komplikasi. Metode:Desain penelitian cross sectional dilakukan pada ibu hamil dengan usia kehamilan lebih dari 20 minggu di RSUP Dr. Wahidin Sudirohusodo dan rumah sakit jejaring pendidikan lainnya sejak bulan Januari hingga Juni tahun 2022. Data dikumpulkan menggunakan sampel darah dan diperiksa lebih lanjut dengan metode ELISA. Uji Chi-Square digunakan untuk menganalisis hubungan antara kadar NGAL dan derajat keparahan PEB. Hasil: Pada penelitian ini mencakup 156 sampel, yang terdiri atas wanita hamil normal (n=53), wanita hamil dengan PEB tanpa komplikasi (n=50), dan wanita hamil dengan PEB dan komplikasi (n=53). Penelitian ini menemukan bahwa semakin berat derajat preeklamsia, maka semakin rendah kadar NGAL-nya yaitu kadar NGAL diamati pada 58% wanita PEB dengan komplikasi dan 32,1% wanita PEB tanpa komplikasi dan 9,8% pada kehamilan normal (p <0,05). Hasil penelitian ini tidak sesuai dengan teori yang menemukan peningkatan kadar NGAL pada pasien PEB. Penurunan kadar NGAL ini mungkin dapat disebabkan oleh prevalensi obesitas yang banyak pada kelompok PEB dengan dan tanpa komplikasi. Obesitas merupakan kondisi inflamasi sistemik dan NGAL dapat bertindak sebagai regulator negatif terhadap aktivitas inflamasi yang dimediasi oleh disfungsi adiposit. Pada kelompok PEB juga didapatkan pemberian MgSO 4 , yang memiliki peran untuk menghambat kadar IL-6 sehingga dapat menurunkan kadar NGAL Kesimpulan: Penurunan kadar NGAL berpotensi untuk menjadi biomarker dalam menilai derajat keparahan preeklamsia.Kata kunci: Derajat keparahan, neutrophil gelatinase associated lipocalin, preeklamsia

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Characteristics and severity of preeclampsia in young and elderly gravidas with hypertensive disease

Cited by 7 publications

References 35 publications

Comparative Study of Mean Platelet Volume in Pre-eclampsia versus Normal Pregnancy in Third Trimester

Comparative Study of Mean Platelet Volume in Pre-eclampsia versus Normal Pregnancy in Third Trimester

The Association between Advanced Maternal Age and the Manifestations of Preeclampsia with Severe Features

Hubungan Antara Neutrophil Gelatinase Associated Lipocaline (NGAL) dan Kejadian Preeklamsia: Penelitian Potong-Lintang

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