Circulating Progenitor Cells and Racial Differences

Tahhan, Ayman Samman; Hammadah, Muhammad; Kelli, Heval Mohamed; Kim, Jeong Hwan; Sandesara, Pratik B.; Alkhoder, Ayman; Kaseer, Belal; Gafeer, Mohamad Mazen; Topel, Matthew; Hayek, Salim S.; O’Neal, Wesley T.; Obideen, Malik; Ko, Yi‐An; Liu, Chang; Hesaroieh, Iraj; Mahar, Ernestine; Vaccarino, Viola; Waller, Edmund K.; Quyyumi, Arshed A.

doi:10.1161/circresaha.118.313282

Cited by 22 publications

(11 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, the frequency of circulating CD34+ cells was shown to differ by race ( 48 ). In addition, CD34+ hematopoietic stem cells have been found to express sex-related hormone receptors that changed functions in in-vitro studies ( 55 , 56 ).…”

Section: Discussionmentioning

confidence: 99%

“…CD34+ cells are also found in the circulation and can be differentiated into hematopoietic, endothelial, and nonhematopoietic lineages and can promote angiogenesis (48) and cardiac repair after injury (49,50). The frequency of CD34+ cells in the BM is used as an indicator of BM potency in the transplant field, and these cells (51)(52)(53) have been shown to repair the damage associated with CVD.…”

Section: Correlation Of Bm-cd34+ Cells With Patient Sexmentioning

confidence: 99%

See 1 more Smart Citation

Sex-Based Differences in Autologous Cell Therapy Trials in Patients With Acute Myocardial Infarction: Subanalysis of the ACCRUE Database

Haller

Gyöngyösi

Chacon‐Alberty³

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Background: Sex-based differences are under-studied in cardiovascular trials as women are commonly underrepresented in dual sex studies, even though major sex-based differences in epidemiology, pathophysiology, and outcomes of cardiovascular disease have been reported. We examined sex-based differences in patient characteristics, outcome, and BM-CD34+ frequency of the ACCRUE (Meta-Analysis of Cell-based CaRdiac studies) database involving patients with acute myocardial infarction (AMI) randomized to autologous cell-based or control treatment.Methods: We compared baseline characteristics and 1-year follow-up clinical data: composite major adverse cardiac and cerebrovascular events (primary endpoint), and changes in left ventricular ejection fraction (LVEF), end-diastolic (EDV), and end-systolic volumes (ESV) (secondary efficacy endpoint) in women and men (N = 1,252; 81.4% men). Secondary safety endpoints included freedom from hard clinical endpoints.Results: In cell-treated groups, women but not men had a lower frequency of stroke, AMI, and mortality than controls. The frequency of BM-CD34+ cells was significantly correlated with baseline EDV and ESV and negatively correlated with baseline LVEF in both sexes; a left shift in regression curve in women indicated a smaller EDV and ESV was associated with higher BM-CD34+ cells in women.Conclusions: Sex differences were found in baseline cardiovascular risk factors and cardiac function and in outcome responses to cell therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Correlation Of Bm-cd34+ Cells With Patient Sexmentioning

confidence: 99%

Sex-Based Differences in Autologous Cell Therapy Trials in Patients With Acute Myocardial Infarction: Subanalysis of the ACCRUE Database

Haller

Gyöngyösi

Chacon‐Alberty³

et al. 2021

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…Because CACs were positive, and heavily right-skewed, generalized linear models with the gamma distribution and log-link were used to examine the association between CACs and VOC metabolites (Figure 1). Models used natural logtransformed VOC metabolites, and were adjusted based on prior literature showing an association with VOC exposure or CAC levels (Fadini et al, 2008;Fadini et al, 2007;Giannotti et al, 2010;O'Toole et al, 2010;Samman Tahhan et al, 2018;Tobler et al, 2010;Xia et al, 2012). Model adjustments included: age, sex, race, BMI, diabetes status, hypertension status, and daily PM2.5 levels.…”

Section: Discussionmentioning

confidence: 99%

Environmental Exposure to Volatile Organic Compounds is Associated with Endothelial Injury

Riggs

Malovichko

Gao

et al. 2021

Preprint

View full text Add to dashboard Cite

Objective: Volatile organic compounds (VOCs) are airborne toxicants abundant in outdoor and indoor air. High levels of VOCs are also present at various Superfund and other hazardous waste sites; however, little is known about the cardiovascular effects of VOCs. We hypothesized that ambient exposure to VOCs exacerbate cardiovascular disease (CVD) risk by depleting circulating angiogenic cells (CACs). Approach and Results: In this cross-sectional study, we recruited 375 non-smokers with low-to-high CVD risk and measured 15 subpopulations of CACs by flow cytometry and 16 urinary metabolites of 12 VOCs by LC/MS/MS. Associations between CAC and VOC metabolite levels were examined using generalized linear models. Our data show that VOC exposure varied by sex, age, and race. In single pollutant models, metabolites of xylene, benzene, and 1,3-butadiene were negatively associated with CAC levels. The metabolite of acrylonitrile was negatively associated with CD45dim/CD146+/CD34+/AC133+ cells and CD45+/CD146+/AC133+, and the toluene metabolite with AC133+ cells. Multipollutant models showed a negative association with metabolites of ethylbenzene/styrene, benzene, and xylene with CD45dim/CD146+/CD34+ cells, independent of other VOC metabolite levels. Cumulative VOC risk score showed a strong negative association with CD45dim/CD146+/CD34+ cells, suggesting that total VOC exposure has a cumulative effect on pro-angiogenic cells. Dose-response relationship showed an increase in CAC levels at low, but depletion at higher levels of VOC exposure. Sex and race, hypertension, and diabetes significantly modified VOC associated CAC depletion. Conclusion: Low-level ambient exposure to VOCs is associated with CAC depletion, which could compromise endothelial repair and angiogenesis, and exacerbate CVD risk.

show abstract

“…All coronary angiograms were conducted by inserting a Judkins catheter into the right radial artery, and the produced results were independently reviewed by two experienced angiographers, both of whom were blinded to corresponding genotyping data. Patients were categorized according to their degree of coronary stenosis, such that they were determined to have 'no CAD', 'nonobstructive CAD', or 'significant CAD' if they exhibited 0%, 1-49%, or ≥50% luminal narrowing in any epicardial coronary artery, respectively, as reported in the CSBC Registry [27]. In our study, 'CAD' is composed of 'nonobstructive CAD' and 'significant CAD'.…”

Section: Methodsmentioning

confidence: 99%

The Interleukin 1 Receptor Type 1 Variant rs2234651 is a Risk Factor for Coronary Artery Disease in a Chinese Han Population: A Case Control Study

Gu¹,

Zhou²,

Wei³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background While increased expression of soluble CD121a (Interleukin 1 Receptor Type 1, IL-1R1) has been shown to be significantly correlated with the severity of coronary artery disease (CAD), it is not yet clear whether IL-1R1 gene variants impact CAD pathogenesis. Methods The present study evaluated the effects of IL-1R1 variants on CAD in a Chinese-Han population; A two-stage case-control study assessed 928 Chinese-Han patients via coronary arteriography for coronary atherosclerosis. The allele and genotype frequencies of the analyzed IL-1R1 polymorphisms were determined via a polymerase chain reaction assay and directly sequenced. Results The IL-1R1 variant rs2234651 was found to be associated with both CAD risk and severity (the degree of exhibited vascular stenosis/number of affected vessels, P = 0.034; Gensini scoring, P = 0.006). Furthermore, significant increase of IL-8 and IL-11 in patients carrying the CT+TT genotype was observed. Finally, serum CD121a levels significantly increased in patients with CAD that harbored the CT+TT genotype ( P <0.05). Conclusions These results demonstrate that the IL-1R1 variant rs2234651 is significantly associated with CAD risk and severity in the analyzed Chinese-Han population and rs2234651 may be a valuable target for CAD prevention and/or treatment.

show abstract

Circulating Progenitor Cells and Racial Differences

Abstract: Black subjects have lower levels of CPCs compared with whites which is partially dependent on lower circulating MMP-9 levels. Impaired regenerative capacity is predictive of adverse outcomes in blacks and may partly account for their increased risk of cardiovascular events.

Cited by 22 publications

References 42 publications

Sex-Based Differences in Autologous Cell Therapy Trials in Patients With Acute Myocardial Infarction: Subanalysis of the ACCRUE Database

Sex-Based Differences in Autologous Cell Therapy Trials in Patients With Acute Myocardial Infarction: Subanalysis of the ACCRUE Database

Environmental Exposure to Volatile Organic Compounds is Associated with Endothelial Injury

The Interleukin 1 Receptor Type 1 Variant rs2234651 is a Risk Factor for Coronary Artery Disease in a Chinese Han Population: A Case Control Study

Contact Info

Product

Resources

About