Potential Drug–Drug Interactions with Antimicrobials in Hospitalized Patients: A Multicenter Point-Prevalence Study

Kuşçu, Ferit; Ulu, Aslıhan; İnal, Ayşe Seza; Suntur, Bedia Mutay; Aydemir, Hande; Gül, Serdar; Ecemiş, Kenan; Kömür, Süheyla; Kurtaran, Behice; Kuşçu, Özlem Özkan; Taşova, Yeşim

doi:10.12659/msm.908589

Cited by 27 publications

(29 citation statements)

References 29 publications

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“…The prevalence of pDDI in antimicrobial prescriptions in this study was lower than that described by Piedade et al 21 , in a large hospital in Jequié -BA, which found 46.5% of prescriptions for antimicrobials with some pDDI, also computing the non-significant ones, and that Kuscu et al 15 , which identified 22.7%. On the other hand, although the proportion of clinically relevant pDDI is lower than that found by other authors, their severity was greater than that described by them.…”

Section: Resultscontrasting

confidence: 81%

“…In recent years, the use of antimicrobials in hospitals has increased dramatically and more than a third of antibiotics are prescribed in disagreement with the guidelines, being a common cause of DRPs and compromising the quality and success of pharmacotherapy and patient safety. 15 The prevalence of prescriptions containing antimicrobials was 36.4% (88), varying from 20% to 50% depending on the inpatient unit and being higher in the ICUs. Rodrigues and Bertoldi 18 identified that 52.4% of ICU patients used at least one antimicrobial in a private hospital in Santa Maria -RS, while Alvim et al 19 observed a prevalence of 25% among patients admitted to the ICU of a hospital in Juiz de Fora -MG, in contrast to the findings by Vicent et al 20 , where 70% of patients received at least one antibiotic during hospitalization of ICU.…”

Section: Resultsmentioning

confidence: 99%

“…The same was observed by Queiroz et al 12 for whom antimicrobials were the main class involved in clinically relevant pDDI in neonatal ICUs, and by Marques et al 13 , who observed that antimicrobials were among the three classes of drugs with the highest prevalence of clinically significant PDDI in the ICU. Beyond them, Ziehl et al 14 identified that antimicrobials were involved in 12 (23.5%) of the 51 pDDI detected in ICU patients and a positive incremental relationship was found between number of medications, length of stay, and number of pDDI; and Kuscu et al 15 multicentric study identified that pDDI involving antimicrobials were present in 22.7% of hospitalized patients.…”

Section: Introductionmentioning

confidence: 99%

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Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study

Pavanello¹,

Farhat²,

Carvalho³

et al. 2021

Rev Bras Farm Hosp Serv Saude

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Objective: To assess the prevalence of pDDI involving antimicrobials and other standardized drugs in a large general hospital in the interior of São Paulo. Methods: quantitative study, with cross-sectional design and data collection by documentary analysis of hospital prescriptions from April to June 2017. Results: 66 clinically relevant pDDI were found, which corresponded to approximately 7.3% of antimicrobial prescriptions, being 93.9% (62) contraindicated / severe and 6.1% (4) moderate. There was no difference in the prevalence of clinically relevant pDDIs between critical and non-critical inpatient, in addition to all contraindicated interactions (10) having occurred in the clinical and surgical units. The most prevalent pDDI were, with respective degrees of documentation, between vancomycin and amikacin (47% - reasonable), clarithromycin and simvastatin (13.6% - good), and ciprofloxacin and simvastatin (7.6% - good). Conclusion: For the proper prevention of potential drug-related problems, mechanisms to guarantee the quality of prescriptions by trained clinical pharmacists are of fundamental importance, in addition to alert systems and drug interaction information for the health team, then ensuring quality pharmacotherapy and patient safety.

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Section: Resultscontrasting

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study

Pavanello¹,

Farhat²,

Carvalho³

et al. 2021

Rev Bras Farm Hosp Serv Saude

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“…We compared the result from Micromedex between the drug list used for metabolic syndrome in human and animal diseases in identity contraindicated and major potential DDIs. The drug list for animal disease treatment identi ed more pairs of contraindicated and major potential DDIs; the reason might be that the drugs used in animals included many drugs related to antiarrhythmic agents, antimicrobials and antihypertensive drugs, which often show a high incidence of potential DDI when prescribed with other drugs [16][17][18]. Veterinary pharmacists should realise when prescribing these drug groups to avoid the severe adverse reactions.…”

Section: Discussionmentioning

confidence: 99%

Comparing potential drug-drug interactions in veterinary medications using two electronic databases

Boonyarattanasoonthorn

Khemawoot

Kijtawornrat

2020

Preprint

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Background: One of the most common global health issues in humans and animals is drug-drug interactions (DDIs). This issue increases the risks associated with healthcare in both human and veterinary medicine, as animals live long lives and receive many medicines to treat their illnesses. Currently, many electronic databases are being used as tools for potential DDI prediction, for example, Micromedex and Drugs.com. The purpose of this study was to examine the different abilities for the identification of potential DDIs in veterinary medicines by Micromedex and Drugs.com. Results: A list of 140 drugs, mainly used for the treatment of disease in animal hospitals, was complied, but the Micromedex and Drugs.com databases could recognise only 96 of these drugs. After inputting the recognised drug list into the databases, Micromedex showed 429 pairs of potential DDIs, whilst Drugs.com showed 842 pairs of potential DDIs. The analysis comparing results between the two databases showed 139 pairs (12.28%) with the same severity and 993 pairs (87.72%) with different severities. Major mechanisms of contraindicated and major potential DDIs were cytochrome P450 induction-inhibition and QT interval prolongation.Conclusion: Although Micromedex had a lower sensitivity to identify potential DDIs than Drugs.com, Micromedex provided more informative documentation. Veterinary pharmacists should evaluate potential DDIs from several databases and communicate with both the veterinarian and animal owner to ensure an appropriate drug prescription.

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“…As with any screening tool, effectiveness of DDI checkers is much higher if used in subpopulations with high risk of the target problem. Risk factors for DDIs in patients at ICU were studied in several settings, and the following were repeatedly reported: the length of stay and number of drugs or therapeutic groups prescribed (3)(4)(5)(6). However, a few other risk factors may be of importance, especially prescription of certain drug groups which are prone to DDIs, like anticonvulsants or anticoagulans (3), but their true significance remain to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

Predictors of potential drug-drug interactions in patients at intensive care unit

Iličković¹,

Orlandić-Čejović²,

Tanasković³

et al. 2019

Acta fac medic Naissensis

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Drug-drug interactions (DDIs) with serious adverse consequences for patients at intensive care unit (ICU) occur with the prevalence of 5.3%. The aim of our study was to reveal the risk factors for potential DDIs among the ICU patients. This retrospective cohort analysis took place in the ICU of the Clinical Center Podgorica, Montenegro, between June 1, 2017 and September 30, 2018. The study was conducted as a chart review of the ICU patients (n = 99) who spent ≥ 2 days in the ICU. The main outcome measure was the number of DDIs per patient. Ninety-four percent of patients had at least one potential DDI, while 20% of patients had at least one potential DDI which required a change of therapy. The number of potential DDIs per patient according to the Medscape was 6.6 ± 9.1 and 3.8 ± 4.9 according to the Epocrates. A higher number of drugs (or therapeutic groups) prescribed per patient increased the number of potential DDIs, including those which required a change of therapy. The patients who were prescribed antiarrhythmics, anticoagulants or two antiplatelet drugs experienced more DDIs than patients without these therapeutic groups, while delirium, dementia and drug allergy were protective factors. The main limitation of our study was its uni-centerdness, which allowed for certain degree of bias. Routine screening of the ICU patients with high number of prescribed drugs who receive antiarrhythmics, anticoagulants or double antiplatelet therapy for potential DDIs may prevent a great deal of DDIs with potentially deleterious effects.

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Potential Drug–Drug Interactions with Antimicrobials in Hospitalized Patients: A Multicenter Point-Prevalence Study

Cited by 27 publications

References 29 publications

Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study

Clinically relevant drug interactions involving antimicrobials in a general hospital: a cross-sectional study

Comparing potential drug-drug interactions in veterinary medications using two electronic databases

Predictors of potential drug-drug interactions in patients at intensive care unit

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