Melanoma metastases occuring 40 years after primary melanoma

Gerlini, Gianni; Tripo, Lara; Sestini, Serena; Brandani, Paola; Giannotti, Vanni; Gattai, Riccardo; Borgognoni, Lorenzo

doi:10.1080/0284186x.2018.1481295

Cited by 2 publications

(1 citation statement)

References 12 publications

(28 reference statements)

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“…Most cases of malignant melanoma have cutaneous spread, but when present, distant metastases have a poor prognosis. Most metastatic relapses occur within three years, and late metastases can occur even after ten years [6,7]. Pleural involvement, although rare, can present as pleural thickening, mimicking mesothelioma, or pleural effusion, as in the case of our patient [8].…”

Section: Discussionmentioning

confidence: 62%

The Great Mimicker: Cutaneous Metastatic Melanoma Presenting as a Non-resolving Pleural Effusion

Gomez¹,

Jospeh²,

Arangan³

et al. 2022

Cureus

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Although melanoma starts as a local disease, it can metastasize to other sites of the body including the lung, brain, liver, and intestines. However, pleural involvement is a rare presentation. Here, we present a case of a 57-year-old man with a history of stage IIA cutaneous melanoma, that relapsed 3 years after cutaneous resection, presenting with a non-resolving pleural effusion. Pleural fluid analysis was consistent with an exudative effusion, and pleural biopsy confirmed metastatic melanoma. The patient was treated with dual therapy of ipilimumab and nivolumab, as per National Comprehensive Cancer Network guidelines, with good response. Thus, we recommend having a high index of clinical suspicion for metastatic pleural melanoma when a patient with a history of cutaneous melanoma presents with a non-resolving pleural effusion.

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Section: Discussionmentioning

confidence: 62%

The Great Mimicker: Cutaneous Metastatic Melanoma Presenting as a Non-resolving Pleural Effusion

Gomez¹,

Jospeh²,

Arangan³

et al. 2022

Cureus

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Skin Malignant Melanoma and Matrix Metalloproteinases: Promising Links to Efficient Therapies

Lazar,

Costea,

Popp

et al. 2024

IJMS

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Skin malignant melanoma (MM) is one of the most frequent and aggressive neoplasia worldwide. Its associated high mortality rates are mostly due to its metastases, while diagnosis and treatment of MM in its early stages is of favorable prognostic. Even skin superficial MMs at incipient local stages can already present with lymph node invasion and distant metastases. Therefore, knowledge of the controllable risk factors and pathogenic mechanisms of MM development, spreading, and metastatic pattern, as well as early diagnosis, are essential to decrease the high mortality rates associated with cutaneous malignant melanoma. Genetic factors are incriminated, although lifetime-acquired genetic mutations appear to be even more frequently involved in the development of MM. Skin melanocytes divide only twice per year and have time to accumulate genetic mutations as a consequence of environmental aggressive factors, such as UV exposure. In the search for more promising therapies, matrix metalloproteinases have become of significant interest, such as MMP-1, MMP-2, MMP-9, and MMP-13, which have been linked to more aggressive forms of cancer and earlier metastases. Therefore, the development of specific synthetic inhibitors of MMP secretion or activity could represent a more promising and effective approach to the personalized treatment of MM patients.

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Melanoma metastases occuring 40 years after primary melanoma

Cited by 2 publications

References 12 publications

The Great Mimicker: Cutaneous Metastatic Melanoma Presenting as a Non-resolving Pleural Effusion

The Great Mimicker: Cutaneous Metastatic Melanoma Presenting as a Non-resolving Pleural Effusion

Skin Malignant Melanoma and Matrix Metalloproteinases: Promising Links to Efficient Therapies

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