Winter Cholecalciferol Supplementation at 51°N Has No Effect on Markers of Cardiometabolic Risk in Healthy Adolescents Aged 14–18 Years

Smith, Taryn J; Tripkovic, Laura; Hauger, Hanne; Damsgaard, Camilla T.; Mølgaard, Christian; Lanham-New, Susan A; Hart, Kathryn

doi:10.1093/jn/nxy079

Cited by 14 publications

(21 citation statements)

References 46 publications

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“…34,35 Overall, the GLM including the influence of measured 25(OH)D 3 start levels and the four SNPs This is consistent with the low to moderate vitamin D 3 supplement dose (5-20 µg per day) studies that tend to yield higher efficiency of treatment. [38][39][40]43,44 The 25(OH)D 3 end level in this study of 115 nmol L −1 is very similar to the plateau level found by Gallagher. At study end, there was an insignificant but mean increase of 6 nmol L −1 .…”

Section: Discussionsupporting

confidence: 89%

Serum 25(OH)D levels after oral vitamin D₃ supplementation and UVB exposure correlate

Datta

Philipsen

Olsen

et al. 2019

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Background The inter‐individual variation in 25(OH)D3 increase (Δ25(OH)D3) after vitamin D3 supplementation was determined and compared with the UVB irradiation response. Methods Nineteen Danish participants received 85 μg vitamin D3 (cholecalciferol) daily for nine weeks with regular serum 25(OH)D3 measurements. These participants had three years earlier taken part in a 9‐week controlled UVB study. The Δ25(OH)D3 was not confounded by ambient UVB, BMI or ethnicity. Results Δ25(OH)D3 was 53 nmol L−1 and almost identical to Δ25(OH)D3 (52 nmol L−1) after UVB. Δ25(OH)D3 ranged from 17 to 91 nmol L−1 (span 74 nmol L−1) and was about half of that observed after UVB irradiation (span 136 nmol L−1). The interquartile ranges for vitamin D3 supplementation (38.8‐71.4 nmol L−1, span: 32.6 nmol L−1) and UVB irradiation (35.7‐65.4 nmol L−1, span: 29.7 nmol L−1) were similar indicating a comparable response of the two interventions. As the 25(OH)D3 start levels (R2 = 0.398, P = 3.8 × 10−3), 25(OH)D3 end levels (R2 = 0.457, P = 1.5 × 10−3) and Δ25(OH)D3 (R2 = 0.253, P = 0.028) between both interventions were correlated, this suggested a possible common individual background for the variation. Four pigment SNPs influenced the variation in the vitamin D3‐induced and UVB‐induced Δ25(OH)D3. A combined model including the influence of these four SNPs and the 25(OH)D3 start level explained 86.8% (P = 1.6 × 10−35) of the individual variation after vitamin D3 supplementation. Conclusion The inter‐individual variation in the two interventions was comparable and had no common demographic but a partly common genetic background.

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Section: Discussionsupporting

confidence: 89%

Serum 25(OH)D levels after oral vitamin D₃ supplementation and UVB exposure correlate

Datta

Philipsen

Olsen

et al. 2019

Photoderm Photoimm Photomed

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“…Inadequate vitamin D status was not an inclusion criterion only the study by Khayyatzadeh et al [27], although around 95% of the study population were either vitamin D deficient or insufficient. In four [28][29][30][31] out of the five included RCTs, mean baseline vitamin D was less than 50 nmol/L.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…The articles included three non-randomized human interventions studies [25][26][27] and five controlled trials of vitamin D supplementation [28][29][30][31]. Three of the studies were conducted in the USA [25,26,29], two in Iran [27,30], one in Denmark [32], and one in each of Saudi Arabia [28] and the United Kingdom [31]. Participant age in the studies ranged from 4 to 18 years, and participant sample size ranged from 14 to 940.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…None of the studies, whether randomized or not, included only hypertensive participants. Further, in Khayyatzadeh et al [27], Javed et al [26], Dong et al [29], Al Daghri et al [28], Hauger et al [32] and Smith et al [31], only healthy, non-hypertensive subjects were recruited. No details regarding baseline prevalence of hypertension were provided in Ashraf et al [25].…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

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Vitamin D Supplementation and Blood Pressure in Children and Adolescents: A Systematic Review and Meta-Analysis

Abboud

2020

Nutrients

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Suboptimal vitamin D status is associated with elevated blood pressure (BP) in children and adolescents. Whether vitamin D supplementation reduces BP remains unclear. To systematically review whether vitamin D supplementation reduces BP in children and adolescents, we conducted a literature review according to the PRISMA statement. We included vitamin-D supplementation human interventions studies that reported on BP as an outcome. We searched PUBMED, MEDLINE, CINAHL, EMBASE, the Cochrane Library, and the clinical trials website. We also hand searched the references of the included articles and previous reviews of vitamin D therapy. No language or time restrictions were applied. We extracted data on population characteristics, baseline and endline vitamin D and BP values, and assessed the risk of bias of the included studies. We performed a narrative review of the findings, conducted a meta-analysis when possible, and performed sensitivity analyses to test the robustness of our results. We assessed the overall quality of the evidence produced in the meta-analysis. We included eight studies in our review and five studies in the meta-analysis, none of which included hypertensive only participants. The risk of bias was variable. In non-randomized studies, no effect of vitamin D supplementation was seen on systolic BP (SBP) (mean difference: 0.39 (95% confidence interval (CI): −0.9; 1.68) mmHg; p = 0.55; I2 = 0%). Only a significant decrease in diastolic BP (DBP) (mean difference: −1.87 (95% CI: −3.02; −0.72) mmHg; p = 0.001; I2 = 0%) was noted. Both analyses had a low quality of evidence. In randomized controlled trials (RCTs), no effect was noted on SBP (mean difference: −2.04 (95% CI: −5.12; 1.04) mmHg; p = 0.19; I2 = 71%) nor DBP (mean difference: 0.01 (95% CI: −1.09; 1.12) mmHg; p = 0.98; I2 = 0%). The final quality of evidence ranged between low and moderate. Sensitivity analyses did not affect the results. Vitamin D supplementation was found to be ineffective in lowering SBP and DBP in children and adolescents.

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“…Activation of the vitamin D receptor by 1,25-dihydroxyvitamin D has also been proposed to affect blood pressure through a variety of mechanisms including involvement of the renin-angiotensin-aldosterone system and vascular smooth muscle (55,56) . Some randomised clinical trials in children and adolescents have indicated potential beneficial effects of vitamin D supplementation on TAG and glucose metabolism markers (12,57) , but most studies have not found any cardiometabolic benefits after an increase in serum concentration of 25(OH) D (9,58,59) . Our analyses were performed in healthy children with mean serum 25(OH)D > 50 nmol/l during autumn, when the serum 25(OH)D is expected to be close to the annual peak, as UVB radiation in Denmark is only sufficient to induce cutaneous vitamin D 3 synthesis from March to late September (60) .…”

Section: Discussionmentioning

confidence: 99%

Vitamin D-related genes and cardiometabolic markers in healthy children: a Mendelian randomisation study

et al. 2020

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Observational studies show associations between low serum 25-hydroxyvitamin D (25(OH)D) and cardiometabolic risk markers. This Mendelian randomisation study examined associations between cardiometabolic markers in children and SNP in genes related to vitamin D metabolism (DHCR7; group-specific complement (GC); cytochrome P450 subfamily IIR1 (CYP2R1); and CYP24A1) and action (CYP27B1 and VDR). In 699 healthy 8–11-year-old children, we genotyped eleven SNP. We generated a genetic risk score based on SNP associated with low 25(OH)D and investigated associations between this and blood pressure, plasma lipids and insulin. Furthermore, we examined whether SNP related to vitamin D actions modified associations between 25(OH)D and the cardiometabolic markers. All GC and CYP2R1 SNP influenced serum 25(OH)D. A risk score based on four of the six SNP was associated with 3·4 (95 % CI 2·6, 4·2) mmol/l lower 25(OH)D per risk allele (P < 0·001), but was not associated with the cardiometabolic markers. However, interactions were indicated for the three VDR SNP (Pinteraction < 0·081) on associations between 25(OH)D and TAG, systolic blood pressure and insulin, which all decreased with increasing 25(OH)D only in major allele homozygotes (β –0·02 (95 % CI –0·04, –0·01) mmol/l; β –0·5 (95 % CI –0·9, –0·1) mmHg; and β –0·5 (95 % CI –1·4, 0·3) pmol/l, respectively). In conclusion, genetic variation affected 25(OH)D substantially, but the genetic score was not associated with cardiometabolic markers in children. However, VDR polymorphisms modified associations with vitamin D, which warrants further investigation of VDR's role in the relationship between vitamin D and cardiometabolic risk.

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Winter Cholecalciferol Supplementation at 51°N Has No Effect on Markers of Cardiometabolic Risk in Healthy Adolescents Aged 14–18 Years

Abstract: Supplementation with vitamin D3 at 10 and 20 μg/d, which increased serum 25(OH)D concentrations during the winter-time, had no effect on markers of cardiometabolic risk in healthy 14- to 18-y-old adolescents. This trial was registered at clinicaltrials.gov as NCT02150122.

Cited by 14 publications

References 46 publications

Serum 25(OH)D levels after oral vitamin D₃ supplementation and UVB exposure correlate

Serum 25(OH)D levels after oral vitamin D₃ supplementation and UVB exposure correlate

Vitamin D Supplementation and Blood Pressure in Children and Adolescents: A Systematic Review and Meta-Analysis

Vitamin D-related genes and cardiometabolic markers in healthy children: a Mendelian randomisation study

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Winter Cholecalciferol Supplementation at 51°N Has No Effect on Markers of Cardiometabolic Risk in Healthy Adolescents Aged 14–18 Years

Abstract: Supplementation with vitamin D3 at 10 and 20 μg/d, which increased serum 25(OH)D concentrations during the winter-time, had no effect on markers of cardiometabolic risk in healthy 14- to 18-y-old adolescents. This trial was registered at clinicaltrials.gov as NCT02150122.

Cited by 14 publications

References 46 publications

Serum 25(OH)D levels after oral vitamin D3 supplementation and UVB exposure correlate

Serum 25(OH)D levels after oral vitamin D3 supplementation and UVB exposure correlate

Vitamin D Supplementation and Blood Pressure in Children and Adolescents: A Systematic Review and Meta-Analysis

Vitamin D-related genes and cardiometabolic markers in healthy children: a Mendelian randomisation study

Contact Info

Product

Resources

About

Serum 25(OH)D levels after oral vitamin D₃ supplementation and UVB exposure correlate

Serum 25(OH)D levels after oral vitamin D₃ supplementation and UVB exposure correlate