Low bone mineral density and associated factors in patients with haemophilia in Colombia

Melo, Claudia Lucía Sossa; Wandurraga-Sánchez, Edwin Antonio; Peña, Ángela María; Jimenez, Sara Ines; Salazar, Luis A.; Ochoa, Miguel; Luna-Gonzalez, Maria; Ortiz, M; Morales, Karla Espinoza; Ayala-Castillo, M; Reyes, David Leonardo; Chalela, Claudia Marcela

doi:10.1111/hae.13516

Cited by 21 publications

(20 citation statements)

References 38 publications

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“…Previous studies reported some discrepancies in the risk factors associated with low bone mass in patients with hemophilia in different populations. While low physical activity, HCV infection, vitamin D deficiency, BMI, arthropathy, and cigarette smoking were the possible risk factors in previous reports (4,7,11,12,14,(24)(25)(26)(27), our data proved that severity of factor VIII / IX deficiency was the most critical risk factor associated with both femoral and spinal LBM. One animal study showed that, unlike normal mice, non-bleeding mice with hemophilia had lower BMD and abnormal bone structure (26,28).…”

Section: Discussionsupporting

confidence: 45%

Prevalence of Low Bone Mass in Patients with Hemophilia and Its Related Ractors in Southern Iran

et al. 2020

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Background: The previous studies reported conflicting outcomes concerning the prevalence and risk factors of low bone mass. The evaluation of bone mass and its related factors in patients with hemophilia in Southern Iran can help prevent osteoporosis and fracture amongst these patients. Objectives: The present study aimed to evaluate bone mass and its related factors in patients with hemophilia in Southern Iran. Methods: This study was conducted on 111 patients with hemophilia A and B. It assessed anthropometric data, sun exposure, puberty, physical activity, and mineral biochemical parameters. Bone mineral density (BMD) was measured via dual-energy X-ray absorptiometry (DXA). Statistical analysis was conducted by SPSS software V. 21. Results: The prevalence of low bone mass for chronological age (LBM) was 20.6% in the lumbar area and 23.7% in the femur. Low lumbar bone mass was merely associated with the severity of factor deficiency (P = 0.037, beta=0.896). Low femoral bone mass was associated with severity of factor deficiency (P = 0.022, beta = 0.939), BMI/BMI percentile (P = 0.013, beta = -0.181), HCV infection (P = 0.012, beta = 1.4), and weight (P = 0.002, Beta = -0.064). Conclusions: The prevalence of low bone mass was high in patients with hemophilia in southern Iran. The severity of the disease, HCV infection, and body mass index were the most relevant related factors.

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Section: Discussionsupporting

confidence: 45%

Prevalence of Low Bone Mass in Patients with Hemophilia and Its Related Ractors in Southern Iran

et al. 2020

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“…Haemophilia patients have been shown to have lower BMD compared with the general population or healthy control group . In the present study, BMD levels of haemophilia patients were compared to those of a healthy control group, and the results were evaluated.…”

Section: Discussionmentioning

confidence: 96%

Decreased bone mineral density and associated factors in severe haemophilia A patients: A case‐control study

et al. 2019

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Introduction Haemophilia patients may exhibit lower levels of bone mineral density (BMD) than the general population for a variety of reasons. Aim We aimed to investigate decreased BMD in people with severe adult haemophilia A (PWH) living in eastern Turkey, and to evaluate the related potential risk factors. Methods The study included 41 PWH and 40 healthy volunteers. Dual‐energy x‐ray absorptiometry (DXA) was used to measure the BMD. Blood tests and body mass index (BMI) were recorded. The Functional Independence Score in Hemophilia (FISH) test was used to measure functional ability status. Results There was a significant difference between the PWH and control groups with respect to femoral neck and total hip BMD (in g/cm2), but the difference for lumbar spine was not significant (P = .017, P < .001, P = .071, respectively). In PWH, patients under 50 years of age, 19.4% were found to have “lower than expected” BMD levels for their age, while 27.8% showed “low normal” levels. In PWH, osteoporosis was found in 60% of the patients over 50 and osteopenia in 20%. Vitamin D insufficiency and deficiency were present in 63.4% of the PWH, significantly higher than the control group (37.5%; P < .001). Conclusion The results indicated that the decrease in BMD was significantly greater in patients with severe haemophilia A than in the normal healthy population. This reduction was correlated with BMI, vitamin D and low functional ability status. However, in multivariate analysis, none of these was a strong independent risk factor.

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“…In addition, according to the results of this study, the prevalence of bone density reduction in the spine and hip bones in patients with hemophilia and hepatitis was not significantly different in term of the severity of hemophilia which is not in line with the results of SossaMelo et al . (2018) [ 29 ] and Lorio et al . (2010).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Bone Density Reduction and Its Related Factors in Hemophilia Patients in South Khorasan Province in 2018

Ehsanbakhsh

Azarkar

Ziaee

et al. 2020

GMJ

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Background: The present study aimed to determine the prevalence of bone density reduction and its associated factors in hemophilia patients in South Khorasan Province in 2018. Materials and Methods: This case-control study was conducted on all patients with hemophilia type A with medical records in Hemophilia center in South Khorasan province. A number of 57 eligible subjects who met the criteria were selected based on census method. Thereafter, 60 non-hemophilic individuals who were similar to hemophilic patients in terms of age and body mass index were selected by convenience sampling method. DXA device was used to measure bone mineral density (BMD) in two locations of femoral neck and lumbar vertebrae. Data were analyzed in SPSS software (version 19), using Chi-square, Fisher’s exact test, and independent t-test. A P-value less than 0.05 was considered statistically significant. Results: The prevalence rate of bone density reduction in spine bone in hemophilia patients was measured at 31.6% and 13.3% in non-hemophilia subjects (P=0.02); moreover, this rate in hip bone was reported as 7% and 5%, respectively (P=0.65). Relative frequency of bone density reduction in the spine and hip bone was not significantly different among hemophilia patients based on age, severity of hemophilia, vitamin D, hepatitis and smoking (P>0.05). However, a significant difference was detected in terms of body mass index (P<0.05). Conclusion: Based on the obtained results, the prevalence of bone density reduction in hemophilic patients was significantly higher, as compared to that of non-hemophilia patients. This necessitates the implementation of drastic preventive measures, prompt diagnosis, timely treatment, and appropriate therapeutic measures. [GMJ.2020;9:e1711]

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Low bone mineral density and associated factors in patients with haemophilia in Colombia

Abstract: Results from the present study showed that haemophilia was associated with a higher frequency of LBMD. Severity of haemophilia, haemophilic arthropathy, and elevated C-reactive protein levels was directly associated with LBMD.

Cited by 21 publications

References 38 publications

Prevalence of Low Bone Mass in Patients with Hemophilia and Its Related Ractors in Southern Iran

Prevalence of Low Bone Mass in Patients with Hemophilia and Its Related Ractors in Southern Iran

Decreased bone mineral density and associated factors in severe haemophilia A patients: A case‐control study

Prevalence of Bone Density Reduction and Its Related Factors in Hemophilia Patients in South Khorasan Province in 2018

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