Increased posterior cingulate cortex efficiency may predict cognitive impairment in asymptomatic HIV patients

Ventura, Nina; Douw, Linda; Corrêa, Diogo Goulart; Netto, Tania Maria; Cabral, Rafael Ferracini; Lopes, Fernanda Cristina Rueda; Gasparetto, Emerson L.

doi:10.1177/1971400918782327

Cited by 9 publications

(6 citation statements)

References 34 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The global network efficiency was associated with the composite Z-score, verbal, executive, and learning Z-score ( Figure 7c). The positive correlation of the network efficiency and executive function performance has been reported in HIV-infected individuals (Ventura et al, 2018), where they focused on the posterior cingulate cortex.…”

Section: Rmfm Revealed Disruption Of Local Dynamics Changes Due To mentioning

confidence: 75%

Whole‐brain computational modeling reveals disruption of microscale brain dynamics in HIV infected individuals

Zhuang

Zhang

Tivarus

et al. 2020

Human Brain Mapping

View full text Add to dashboard Cite

MRI-based neuroimaging techniques have been used to investigate brain injury associated with HIV-infection. Whole-brain cortical mean-field dynamic modeling provides a way to integrate structural and functional imaging outcomes, allowing investigation of microscale brain dynamics. In this study, we adopted the relaxed mean-field dynamic modeling to investigate structural and functional connectivity in 42 HIV-infected subjects before and after 12-week of combination antiretroviral therapy (cART) and compared them with 46 age-matched healthy subjects. Microscale brain dynamics were modeled by a set of parameters including two regionspecific microscale brain properties, recurrent connection strengths, and subcortical inputs. We also analyzed the relationship between the model parameters (i.e., the recurrent connection and subcortical inputs) and functional network topological characterizations, including smallworldness, clustering coefficient, and network efficiency. The results show that untreated HIV-infected individuals have disrupted local brain dynamics that in part correlate with network topological measurements. Notably, after 12 weeks of cART, both the microscale brain dynamics and the network topological measurements improved and were closer to those in the healthy brain. This was also associated with improved cognitive performance, suggesting that improvement in local brain dynamics translates into clinical improvement.

show abstract

Section: Rmfm Revealed Disruption Of Local Dynamics Changes Due To mentioning

confidence: 75%

Whole‐brain computational modeling reveals disruption of microscale brain dynamics in HIV infected individuals

Zhuang

Zhang

Tivarus

et al. 2020

Human Brain Mapping

View full text Add to dashboard Cite

show abstract

“…Further, HIV has been linked to reduced regional and global cortical myelin [39] and weaker activity in the PCC [40][41][42][43][44], which has been associated with poorer cognitive functioning in PWH [45]. In contrast to the PCC, the mPFC is critical for executive functions including attention, cognitive flexibility, working memory, and decision-making [46].…”

Section: Discussionmentioning

confidence: 99%

“…Further, those who fail to adequately reduce activity in the PCC while undergoing cognitively-demanding tasks often exhibit cognitive inefficiencies [ 31 – 35 ], and studies have shown that healthy older individuals express stronger PCC activity while undergoing an externally directed task relative to younger individuals [ 36 – 38 ]. Further, HIV has been linked to reduced regional and global cortical myelin [ 39 ] and weaker activity in the PCC [ 40 – 44 ], which has been associated with poorer cognitive functioning in PWH [ 45 ]. In contrast to the PCC, the mPFC is critical for executive functions including attention, cognitive flexibility, working memory, and decision-making [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Epigenetic aging is associated with aberrant neural oscillatory dynamics serving visuospatial processing in people with HIV

Schantell

Taylor

Spooner

et al. 2022

Aging

View full text Add to dashboard Cite

Background: Despite effective antiretroviral therapy, cognitive impairment and other aging-related comorbidities are more prevalent in people with HIV (PWH) than in the general population. Previous research examining DNA methylation has shown PWH exhibit accelerated biological aging. However, it is unclear how accelerated biological aging may affect neural oscillatory activity in virally suppressed PWH, and more broadly how such aberrant neural activity may impact neuropsychological performance. Methods: In the present study, participants (n = 134) between the ages of 23 -72 years underwent a neuropsychological assessment, a blood draw to determine biological age via DNA methylation, and a visuospatial processing task during magnetoencephalography (MEG). Our analyses focused on the relationship between biological age and oscillatory theta (4-8 Hz) and alpha (10 -16 Hz) activity among PWH (n=65) and seronegative controls (n = 69). Results: PWH had significantly elevated biological age when controlling for chronological age relative to controls. Biological age was differentially associated with theta oscillations in the left posterior cingulate cortex (PCC) and with alpha oscillations in the right medial prefrontal cortex (mPFC) among PWH and seronegative controls. Stronger alpha oscillations in the mPFC were associated with lower CD4 nadir and lower current CD4 counts, suggesting such responses were compensatory. Participants who were on combination antiretroviral therapy for longer had weaker theta oscillations in the PCC. Conclusions: These findings support the concept of interactions between biological aging and HIV status on the neural oscillatory dynamics serving visuospatial processing. Future work should elucidate the long-term trajectory and impact of accelerated aging on neural oscillatory dynamics in PWH.

show abstract

“…While increased neural activation of this region may not be aberrant, hyperactivation may signal neural inefficiency reflective of difficulty in assessing risk probability. In a functional network connectivity analysis of persons with HIV, decreased PCC efficiency was identified in persons with cognitive dysfunction compared to those without cognitive dysfunction (Ventura et al, 2018). The authors theorized that this "hypermodulation" of the PCC was due to a need to compensate for HIV-associated neural injury to avoid or postpone cognitive deterioration.…”

Section: Discussionmentioning

confidence: 99%

Neural sensitivity to risk in adults with co-occurring HIV infection and cocaine use disorder

Bell

Towe

Lalee

et al. 2020

Cogn Affect Behav Neurosci

View full text Add to dashboard Cite

Persons with co-occurring HIV infection and cocaine use disorder tend to engage in riskier decision-making. However, the neural correlates of sensitivity to risk are not well-characterized in this population. The purpose of this study was to examine the neural interaction effects of HIV infection and cocaine use disorder to sensitivity to risk. The sample included 79 adults who differed on HIV status and cocaine use disorder. During functional magnetic resonance imaging (fMRI), participants completed a Wheel of Fortune (WoF) task that assessed neural activation in response to variations of monetary risk (i.e., lower probability of winning a larger reward). Across groups, neural activation to increasing risk was in cortical and subcortical regions similar to previous investigations using the WoF in nondrug-using populations. Our analyses showed that there was a synergistic effect between HIV infection and cocaine use in the left precuneus/posterior cingulate cortex and hippocampus, and right postcentral gyrus, lateral occipital cortex, cerebellum, and posterior parietal cortex. HIV+ individuals with cocaine use disorder displayed neural hyperactivation to increasing risk that was not observed in the other groups. These results support a synergistic effect of co-occurring HIV infection and cocaine dependence in neural processing of risk probability that may reflect compensation. Future studies can further investigate and validate how neural activation to increasing risk is associated with risk-taking behavior.

show abstract

Increased posterior cingulate cortex efficiency may predict cognitive impairment in asymptomatic HIV patients

Cited by 9 publications

References 34 publications

Whole‐brain computational modeling reveals disruption of microscale brain dynamics in HIV infected individuals

Whole‐brain computational modeling reveals disruption of microscale brain dynamics in HIV infected individuals

Epigenetic aging is associated with aberrant neural oscillatory dynamics serving visuospatial processing in people with HIV

Neural sensitivity to risk in adults with co-occurring HIV infection and cocaine use disorder

Contact Info

Product

Resources

About