Protective Effects of Foods Containing Flavonoids on Age-Related Cognitive Decline

Abstract

Flavonoids have been found to decrease neuroinflammation, reduce oxidative stress, and mediate neuroplasticity in animal models of neurodegeneration and aging. Injecting flavonoids encased in metal nanoparticles may further enhance the efficacy of flavonoids. Animal studies also demonstrate that flavonoid supplementation may alleviate neurodegenerative cognitive and memory impairments. Limited human studies, however, demonstrate the need for further clinical research investigating flavonoids. Flavonoid supplementation, as well as dietary modification to include whole foods high in flavonoids, may provide therapeutic potential for aging individuals experiencing cognitive deficits resulting from neurodegeneration.

The effect of blueberry interventions on cognitive performance and mood: A systematic review of randomized controlled trials

“…The potential effect of blueberry interventions on cognitive performance has been discussed in previous systematic literature reviews which tended to focus more generally on polyphenols or specific classes of these compounds (Bell et al, 2015b;Gildawie et al, 2018;Kent et al, 2017b;Lamport et al, 2012). For example, in 2012, a systematic literature review of polyphenol-rich foods and cognitive performance identified one non-randomized, single arm trial that investigated the use of blueberry interventions for cognition (Lamport et al, 2012), which did not meet the inclusion criteria for this review.…”

Flavonoids as positive allosteric modulators of α7 nicotinic receptors

“…On the other hand, there is increasing epidemiological and experimental data showing that dietary intake of flavonoids confers protection against multiple chronic diseases, improves cognitive performance and reduces the incidence of age-related neurological decline (Bakoyiannis et al, 2019;Ebrahimi and Schluesener, 2012;Flanagan et al, 2018;Gildawie et al, 2018;Spencer et al, 2009;Vauzour et al, 2015).…”

Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study

“…In this context, a number of lifestyle factors, including components of diet, have been identified as potential candidates for improving cognitive function. These include whole dietary patterns such as the Mediterranean diet and components of food such as the flavonoids [ 2 ].…”