The coexistence of lupus erythematosus panniculitis and subcutaneous panniculitis-like T-cell lymphoma in the same patient

Wu, Xinyu; Subtil, Antonio; Craiglow, Brittany G.; Watsky, Kalman L.; Marks, Asher; Ko, Christine J.

doi:10.1016/j.jdcr.2017.08.021

Cited by 14 publications

(10 citation statements)

References 18 publications

(18 reference statements)

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“…Certain morphologic findings favor the diagnosis of LEP; these include (1) the presence of involvement of the epidermis and periadnexal tissue, (2) lymphoid follicles with reactive germinal centers, (3) abundant plasma cells, (4) hyaline fat necrosis, and (5) mucin deposition [ 12 , 14 ]. The salient immunohistochemical features distinguishing SPTCL from LEP include the presence of Ki67 hotspots and the absence of CD20 + aggregates [ 15 , 16 ]. Recently, atypical lymphocytic lobular panniculitis representing the transitional state with overlapping histopathologic and molecular features between these two entities was proposed [ 13 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous Panniculitis-like T-Cell Lymphoma with a Transformation to Lupus Erythematosus Panniculitis: A Case Report

Tawanwongsri

Thongsroy

2022

Case Rep Dermatol

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Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare primary cutaneous lymphoma characterized by infiltration of the subcutaneous tissue by neoplastic cytotoxic T cells mimicking panniculitis. There is a strong association between SPTCL and lupus erythematosus panniculitis (LEP). However, patients who were diagnosed with LEP with a preceding diagnosis of SPTCL have been scarcely reported. We herein reported a 21-year-old Thai woman presenting to a dermatology clinic for evaluation of a 1-month history of a painful mass on the right buttock and bilateral upper eyelid swelling. A subcutaneous mass which was 5 by 2 cm in diameter, tender, firm, and fixed with a smooth surface was palpated over the upper outer quadrant of her right gluteal area. After a diagnosis of SPTCL had been made based on the histological and immunohistochemical studies, treatment with oral dexamethasone and ciclosporin A was initially started. Because of intolerance to adverse reactions of dexamethasone, only ciclosporin A was given. Improvement was not achieved at 6-month follow-up. She then underwent the re-incisional biopsy at the same gluteal area and the histological features were consistent with LEP. After hydroxychloroquine was given, the lesion resolved within 3 months, and no recurrence was detected during the following 6-month follow-up. We emphasize that long-term follow-up of patients with SPTCL is required. Additionally, in case of poor response to the given treatment, a repeat skin biopsy should be considered in order to determine the proper management.

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Section: Discussionmentioning

confidence: 99%

Subcutaneous Panniculitis-like T-Cell Lymphoma with a Transformation to Lupus Erythematosus Panniculitis: A Case Report

Tawanwongsri

Thongsroy

2022

Case Rep Dermatol

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“…In addition, our patient showed predominately atypical lymphocytes infiltrate, CD8 positivity, not shown in these images, and granzyme positivity, present in the cytotoxic T cell. 14 To differentiate both entities, new criteria have been proposed, based on the expression of human myxovirus resistance protein 1 (MxA) and the presence of plasmacytoid dendritic cells clusters, that are present only in lupus panniculitis. 15 There is no standardized therapeutic approach for SPTCL; multichemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisolone was the preferred regimen, with overall remission rates of 50%.…”

Section: Discussionmentioning

confidence: 99%

Subcutaneous Disseminated Nodules in a 13-Year-Old Girl: Answer

Marín-Hernández

Landini

Gutiérrez-Rivera

et al. 2021

The American Journal of Dermatopathology

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“…Primary cutaneous gamma/delta T‐cell lymphoma is the other variant of lymphoma that may present with panniculitis lesions 29 . Differentiating subcutaneous panniculitis‐like T‐cell lymphoma and lupus panniculitis is challenging due to the possibility of some morphological resemblance, as well as histological similarities, and this should also be briefly argued 30,31 …”

Section: Various Panniculitides – What Is Essential To Know?mentioning

confidence: 99%

Ulcerative versus non‐ulcerative panniculitis: is it time for a novel clinical approach to panniculitis?

2020

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Panniculitis, or inflammation of the fatty tissue, is an ongoing diagnostic challenge to both dermatologists and pathologists. The basis of the current panniculitis classification is histology, whether the inflammation is mainly located in the fibrovascular septa or in the adipose lobules thereafter with or without vasculitis. However, overall, the difficulty rises due to various terminologies and lack of clinical relevance with this classification. In addition to that, the majority of panniculitides have mixed infiltration of both lobular and septal and not a clear‐cut distinction. The aim of this article is to provide a novel clinical algorithm to the diagnosis of panniculitis and thus to provide guidelines for all clinicians who may encounter this challenging condition in their clinical practice.

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The coexistence of lupus erythematosus panniculitis and subcutaneous panniculitis-like T-cell lymphoma in the same patient

Cited by 14 publications

References 18 publications

Subcutaneous Panniculitis-like T-Cell Lymphoma with a Transformation to Lupus Erythematosus Panniculitis: A Case Report

Subcutaneous Panniculitis-like T-Cell Lymphoma with a Transformation to Lupus Erythematosus Panniculitis: A Case Report

Subcutaneous Disseminated Nodules in a 13-Year-Old Girl: Answer

Ulcerative versus non‐ulcerative panniculitis: is it time for a novel clinical approach to panniculitis?

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