Genetic Risk Stratification

Roberts, Robert

doi:10.1161/circulationaha.118.034732

Cited by 12 publications

(8 citation statements)

References 5 publications

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“…The phenotypic susceptibility to ASCVD demonstrated by race/ethnicity is a function of genetics, where an aggregation of allelic variants produces significant pro-atherosclerotic genetic variations. This implies that total individual genetic risk burden for CAD is proportional to the number of genetic risk variants inherited [30] . This may introduce risk via the traditional risk factors and also emerging risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…This may introduce risk via the traditional risk factors and also emerging risk factors. For this reason, there are proponents of a genetic risk score to supplement ASCVD risk scores that further discriminate an individual's risk beyond traditional risk factors alone [ 30 , 31 ]. The impact of race on ASCVD risk estimators has been assessed and found to result in significant changes in risk classification [32] .…”

Section: Discussionmentioning

confidence: 99%

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Atherosclerotic cardiovascular disease risk among Ghanaians: A comparison of the risk assessment tools.

Agyekum,

Akumiah,

Nguah

et al. 2024

American Journal of Preventive Cardiology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Atherosclerotic cardiovascular disease risk among Ghanaians: A comparison of the risk assessment tools.

Agyekum,

Akumiah,

Nguah

et al. 2024

American Journal of Preventive Cardiology

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“…The treatment of CAD depends on the stage and severity of the disease and may include palliative or specific therapies. Prevention of atherosclerosis and its risk factors is essential for improving the quality of life and survival of patients with CAD [3]. Management of CAD involves both primary and secondary prevention strategies [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…Prevention of atherosclerosis and its risk factors is essential for improving the quality of life and survival of patients with CAD [3]. Management of CAD involves both primary and secondary prevention strategies [3,4].…”

Section: Introductionmentioning

confidence: 99%

Mean Platelet Volume and Its Association With In-Hospital Outcomes in Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Ekmekci,

Karaca,

Kimiaei

et al. 2024

Cureus

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BackgroundMean platelet volume (MPV), reflecting platelet size and activation, has been associated with cardiovascular disease (CVD) risk and mortality. Yet, its prognostic significance in acute coronary syndrome (ACS) patients undergoing primary percutaneous coronary intervention (PCI) remains uncertain. This study investigates whether elevated MPV levels upon admission in ST-segment elevation myocardial infarction (STEMI) patients predict adverse in-hospital outcomes after primary PCI. ObjectivesThe aim of this study was to measure MPV in patients with STEMI who underwent primary PCI and to evaluate its association with in-hospital outcomes such as death, recurrent myocardial infarction, heart failure, and bleeding. MethodsWe enrolled 400 consecutive patients with STEMI (mean age 56.20 years, 356 males, 44 females) who underwent primary PCI at our center. We obtained MPV values from complete blood count tests performed at admission. We divided the patients into two groups based on the normal MPV range of 7.40 to 12 fL. We compared the baseline characteristics and in-hospital outcomes of the two groups. We used Cox proportional hazards regression analysis to adjust for potential confounders and evaluate the impact of MPV on in-hospital outcomes. ResultsThere was no significant difference in MPV values between the two groups (9.10 ± 1.20 fL vs. 9.00 ± 1.10 fL, p = 0.54). Patients who died exhibited higher age, male predominance, hypertension, diabetes, a lower left ventricular ejection fraction, lower levels of low-density lipoprotein cholesterol, and lower levels of hemoglobin and hematocrit compared to survivors. MPV was not associated with any of the in-hospital outcomes in the unadjusted or adjusted analyses. ConclusionIn this cohort of patients with STEMI who underwent primary PCI, admission MPV was not a predictor of inhospital outcomes. Further studies are needed to clarify the role of MPV in the pathophysiology and prognosis of ACS.

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“…2 Great strides in cardiovascular genetic and genomic research have led to increased use of genetic screening, the application of polygenic risk scores in practice, and the use of genomic information to guide interventions. [3][4][5] Although these advances hold tremendous potential to improve cardiovascular health and to prevent and treat cardiovascular disease, there are grave concerns that barriers to participation in genetic and genomic research will increase existing health inequities for marginalized racial and ethnic groups and Indigenous populations. 6 Among these barriers is underrepresentation of marginalized and Indigenous population groups in genetic and genomic research.…”

mentioning

confidence: 99%

Considerations for Cardiovascular Genetic and Genomic Research With Marginalized Racial and Ethnic Groups and Indigenous Peoples: A Scientific Statement From the American Heart Association

Mudd‐Martin¹,

Cirino²,

Barcelona³

et al. 2021

Circ: Genomic and Precision Medicine

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Historically marginalized racial and ethnic groups and Indigenous peoples are burdened by significant health inequities that are compounded by their underrepresentation in genetic and genomic research. Of all genome-wide association study participants, ≈79% are of European descent, despite this group constituting only 16% of the global population. For underrepresented populations, polygenic risk scores derived from these studies are less accurate in predicting disease phenotypes, novel population-specific genetic variations may be misclassified as potentially pathogenic, and there is a lack of understanding of how different populations metabolize drugs. Although inclusion of marginalized racial and ethnic groups and Indigenous peoples in genetic and genomic research is crucial, scientific studies must be guided by ethical principles of respect, honesty, justice, reciprocity, and care for individuals and communities. Special considerations are needed to support research that benefits the scientific community as well as Indigenous peoples and marginalized groups. Before a project begins, collaboration with community leaders and agencies can lead to successful implementation of the study. Throughout the study, consideration must be given to issues such as implications of informed consent for individuals and communities, dissemination of findings through scientific and community avenues, and implications of community identity for data governance and sharing. Attention to these issues is critical, given historical harms in biomedical research that marginalized groups and Indigenous peoples have suffered. Conducting genetic and genomic research in partnership with Indigenous peoples and marginalized groups guided by ethical principles provides a pathway for scientific advances that will enhance prevention and treatment of cardiovascular disease for everyone.

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Genetic Risk Stratification

Cited by 12 publications

References 5 publications

Atherosclerotic cardiovascular disease risk among Ghanaians: A comparison of the risk assessment tools.

Atherosclerotic cardiovascular disease risk among Ghanaians: A comparison of the risk assessment tools.

Mean Platelet Volume and Its Association With In-Hospital Outcomes in Patients With Acute ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Considerations for Cardiovascular Genetic and Genomic Research With Marginalized Racial and Ethnic Groups and Indigenous Peoples: A Scientific Statement From the American Heart Association

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