2018
DOI: 10.1111/ejn.13994
|View full text |Cite
|
Sign up to set email alerts
|

Social defeat stress induces hyperalgesia and increases truncated BDNF isoforms in the nucleus accumbens regardless of the depressive‐like behavior induction in mice

Abstract: Epidemiological studies have shown a close association between pain and depression. There is evidence showing this association as patients with depression show a high chronic pain prevalence and vice versa. Considering that social stress is critical for the development of depression in humans, we used a social defeat stress (SDS) model which induces depressive-like behavior in mice. In this model, mice are exposed to an aggressor mouse for ten days, suffering brief periods of agonistic contact and long periods… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

1
20
0
4

Year Published

2019
2019
2024
2024

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 25 publications
(25 citation statements)
references
References 56 publications
1
20
0
4
Order By: Relevance
“…www.bio-protocol.org/e3197 Bio-protocol 9(06): e3197. DOI:10.21769/BioProtoc.3197 (Pagliusi et al, 2018) as well as all the behavioral results presented here. We are extremely grateful for the previous studies carried out by Golden et al (2011) which allowed us to be able to replicate the social defeat stress model even with modifications.…”
Section: Notessupporting
confidence: 75%
See 2 more Smart Citations
“…www.bio-protocol.org/e3197 Bio-protocol 9(06): e3197. DOI:10.21769/BioProtoc.3197 (Pagliusi et al, 2018) as well as all the behavioral results presented here. We are extremely grateful for the previous studies carried out by Golden et al (2011) which allowed us to be able to replicate the social defeat stress model even with modifications.…”
Section: Notessupporting
confidence: 75%
“…After this period a relationship of social submission is characterized, typically observed in human relations. As a result, stressed mice develop several physiological and behavioral changes, including altered levels of corticosterone, cardiac hypertrophy, circadian rhythm disturbances, widespread pain, anxiety, despair behavior, anhedonia and social avoidance ( Krishnan et al , 2007 ; Pagliusi et al , 2018 ). Social interaction level is used to assess depressive-like behavior and, interestingly, some mice submitted to this social defeat stress protocol are resistant and do not develop social avoidance, similar to what occurs in humans, where not all individuals exposed to some form of chronic social stress develops psychopathologies ( Krishnan et al , 2007 ).…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The chronic stress can both increase central sympathetic outflow and alter the immune response of the individual. It has been shown in animal models that chronic stress in the form of social defeat increases the susceptibility to pain and hyperalgesia [38,39].…”
Section: Stress As a Basis For Fmmentioning
confidence: 99%
“…Stress‐induced analgesia is influenced by age, gender and prior experience with stressful conditions (Butler & Finn, 2009). Stress and pain are two complicated phenomena with a complex relationship where pain can cause stress (Sieberg et al., 2018); stress may increase or decrease pain (Heidari‐Oranjaghi et al., 2012; Pagliusi Jr et al, 2018; Shamsizadeh et al., 2014). It appears that acute stress can produce analgesia in animals and humans, while repetitive stress seems to favour the induction of hyperalgesia in rodents (Bardin et al., 2009).…”
Section: Introductionmentioning
confidence: 99%