In vivo investigation on the chronic hepatotoxicity induced by sertraline

Al‐Μansour, Mubarak; Jarrar, Yazun; Jarrar, Bashir M.

doi:10.1016/j.etap.2018.05.021

Cited by 23 publications

(9 citation statements)

References 32 publications

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“…Kupffer cells have phagocytic purposes and their hyperplasia shows that all animals were exposed to hepatic oxidative stress [ 43 ]. Hydropic degeneration is a vacuolization in which the amount of intracellular water increases, caused by disturbance of ionic and fluid balance, commonly reversible and nonlethal process, but can lead to cellular degeneration (necrosis) in more severe cases [ 43 , 44 ], suggesting that anacardic acid may have contributed to some level of ionic unbalance.…”

Section: Resultsmentioning

confidence: 99%

Toxicological and genotoxic evaluation of anacardic acid loaded-zein nanoparticles in mice

et al. 2020

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Section: Resultsmentioning

confidence: 99%

Toxicological and genotoxic evaluation of anacardic acid loaded-zein nanoparticles in mice

et al. 2020

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“…A recent study showed that ACDB5 -deficiency in a patient led to an accumulation of very long-chain fatty acid in plasma resulting from an impaired β-oxidation 37 . In a recent study, epoxide hydrolase 2 ( EPHX2 ) expression was decreased in liver tissue of male rabbits treated with the antidepressant drug sertraline, where a reduced metabolizing capacity of drugs and fatty acids was hypothesized as potential basis of hepatoxicity 38 . This observation is in accordance with our finding on decreased EPHX2 expression in human liver.…”

Section: Discussionmentioning

confidence: 99%

Hepatic gene expression explains primary drug toxicity in bipolar disorder

et al. 2019

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In bipolar disorder (BPD), long-term psychotropic drug treatment is often necessary to prevent relapse or recurrence. Nevertheless, adverse drug effects including disturbances in hepatic metabolism are observed and still poorly understood. Here, the association between hepatic gene expression and histopathological changes of the liver was investigated. By the use of microarrays (Affymetrix U133 plus2.0), a genome-wide expression study was performed on BPD patients with psychotropic drug treatment (n = 29) compared to unaffected controls (n = 20) and validated by quantitative real-time PCR. WebGestalt was used to identify over-represented functional pathways of the Reactome database. Association analyses between histopathological changes and differentially expressed genes comprised in the over-represented functional pathways were performed using regression analyses, from which feature-expression heatmaps were drawn. The majority of identified genes were underexpressed and involved in energy supply, metabolism of lipids and proteins, and the innate immune system. Positive associations were found for genes involved in all pathways and degenerative changes. The strongest negative association was observed between genes involved in energy supply and hepatic activity, as well as inflammation. In summary, we found a possible association between gene expression involved in various biological pathways and histopathological changes of the liver in BPD. Further, we found support for the probable primary toxic effect of psychotropic drugs on hepatic injury in BPD. Even if the safety of psychotropic drugs improves, adverse effects especially on hepatic function should not be underestimated.

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“…In an in vivo study, significant morphometric and hepatic histological changes, such as hepatocyte necrosis and hydropic degeneration, were detected in Sertralinetreated rabbits orally (8 mg/kg) for 9 weeks, which was consistent with the histopathological results of this study. It was suggested that, the hepatic necrosis could indicate oxidative stress by glutathione depletion as a consequence of Sertraline toxicity (Almansour et al 2018). The studies represent that Sertraline consumption during pregnancy is associated with shortterm and long-term adverse effects in children (Shen et al 2017).…”

Section: Resultsmentioning

confidence: 98%

Studying the Liver Function in Male Neonates of Rats Born to Sertraline-Treated Mothers

Safaei

Shariati

2021

JITV

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<p>Sertraline is an antidepressant which has toxic effects on the liver. This study was conducted to evaluate the effect of Sertraline administration in pregnancy on liver function of male neonates of rats. Twenty-five pregnant female Wistar rats were divided into 4 groups of 5.<strong> </strong>The control group did not receive any drug treatments, but experimental (Exp) groups 1, 2 and 3 received 5, 10 and 20 mg/kg Sertraline as gavage throughout the pregnancy, respectively. Twenty-two days after birth, male rats were divided into 4 groups of 10 based on the previous division and after weighing, by taking blood directly from the heart, serum levels of Alanine transaminase (Alt), Aspartate transaminase (AST), Alkaline phosphatase (Alp), Albumin (Alb), Total protein (TP), and Bilirubin (Bili) were measured and the liver tissue was also analyzed histopathologically after weighing. In Exp groups, a significant decrease in body weight, TP and Alb serum levels were observed compared to the control group (p<0.05). In Exp group 3, a significant decrease in liver weight was observed compared to the control group (p˂0.05). In Exp groups 2 and 3, a significant increase in serum levels of Alp, Alt and Bili in was observed compared to the control group (p˂0.05). A significant increase in AST serum level was observed in Exp groups compared to the control group (p˂0.05). Liver tissue destruction was observed in all 3 Exp groups. The administration of Sertraline in pregnant female rats causes liver damage and increases liver enzymes and blood biochemical parameters in their male offspring.</p>

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In vivo investigation on the chronic hepatotoxicity induced by sertraline

Cited by 23 publications

References 32 publications

Toxicological and genotoxic evaluation of anacardic acid loaded-zein nanoparticles in mice

Toxicological and genotoxic evaluation of anacardic acid loaded-zein nanoparticles in mice

Hepatic gene expression explains primary drug toxicity in bipolar disorder

Studying the Liver Function in Male Neonates of Rats Born to Sertraline-Treated Mothers

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