Human Acellular Dermis as Spacer for Small-Joint Arthroplasty: Analysis of Revascularization in a Rabbit Trapeziectomy Model

Banks, Kian C.; Squitieri, Lee; Bramos, Athanasios; Johnson, M. P.; Gardner, Daniel J.; Pourmoussa, Austin J.; Jung, Eunson; Lee, Gene K.; Perrault, David; Fedenko, Alexander N.; Kim, Gene; Han, Bo; Hong, Young‐Kwon; Kulber, David A.; Wong, Alex K.

doi:10.1097/prs.0000000000004629

Plastic &Amp; Reconstructive Surgery

2018

DOI: 10.1097/prs.0000000000004629

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Human Acellular Dermis as Spacer for Small-Joint Arthroplasty: Analysis of Revascularization in a Rabbit Trapeziectomy Model

Kian C. Banks

Lee Squitieri

Athanasios Bramos

et al.

Abstract: The trapeziectomy joint space supports both cellular and vascular ingrowth into human acellular dermal matrix.

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Cited by 2 publications

References 24 publications

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Viability of acellular biologic graft for nipple-areolar complex reconstruction in a non-human primate model

Caronna¹,

Rosenberg²,

Graham³

et al. 2021

Sci Rep

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Many of the > 3.5 million breast cancer survivors in the US have undergone breast reconstruction following mastectomy. Patients report that nipple-areolar complex (NAC) reconstruction is psychologically important, yet current reconstruction techniques commonly result in inadequate shape, symmetry, and nipple projection. Our team has developed an allogeneic acellular graft for NAC reconstruction (dcl-NAC) designed to be easy to engraft, lasting, and aesthetically pleasing. Here, dcl-NAC safety and host-mediated re-cellularization was assessed in a 6-week study in rhesus macaque non-human primates (NHPs). Human-derived dcl-NACs (n = 30) were engrafted on the dorsum of two adult male NHPs with each animal’s own nipples as controls (n = 4). Weight, complete blood counts, and metabolites were collected weekly. Grafts were removed at weeks 1, 3, or 6 post-engraftment for histology. The primary analysis evaluated health, re-epithelialization, and re-vascularization. Secondary analysis evaluated re-innervation. Weight, complete blood counts, and metabolites remained mostly within normal ranges. A new epidermal layer was observed to completely cover the dcl-NAC surface at week 6 (13–100% coverage, median 93.3%) with new vasculature comparable to controls at week 3 (p = 0.10). Nerves were identified in 75% of dcl-NACs (n = 9/12) at week 6. These data suggest that dcl-NAC is safe and supports host-mediated re-cellularization.

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Viability of acellular biologic graft for nipple-areolar complex reconstruction in a non-human primate model

Caronna¹,

Rosenberg²,

Graham³

et al. 2021

Sci Rep

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Engineered nanovesicles from stromal vascular fraction promote angiogenesis and adipogenesis inside decellularized adipose tissue through encapsulating growth factors

Tang

Zeng

et al. 2023

Sci Rep

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Acellular matrix is a commonly used biomaterial in the field of biomedical engineering and revascularization is the key process to affect the effect of acellular matrix on tissue regeneration. The application of bioactive factors related to angiogenesis has been popular in the regulation of revascularization, but the immune system clearance, uncontrollable systemic reactions, and other factors make this method face challenges. Recent reports showed that engineered cells into nanovesicles can reorganize cell membranes and encapsulate cellular active factors, extending the in vitro preservation of cytokines. However, the problems of exogenous biological contamination and tumorigenicity restricted the clinical transformation and wide application of this method. Here, we for the first time engineer stromal vascular fraction (SVF) which is extracted from fat into nanovesicles (SVF-EVs) for angiogenesis in the acellular matrix. SVF-EVs not only promote the migration of vascular endothelial cells in vitro, but also facilitate the lipogenic differentiation of mesenchymal stem cells. In vivo, SVF-EVs enhanced the retention of decellularized adipose tissue after transplanting to the subcutaneous area of nude mice. Immunofluorescence staining further showed that SVF-EVs promoted the formation of vascular networks with large lumen diameter in the grafted acellular matrix, accompanied by adipocyte regeneration peripherally. These findings reveal that SVF-EVs can be a viable method for accelerating revascularization in acellular matrix, and this process of squeezing tissue into nanovesicles shows the potential for rapid clinical transformation.

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Human Acellular Dermis as Spacer for Small-Joint Arthroplasty: Analysis of Revascularization in a Rabbit Trapeziectomy Model

Abstract: The trapeziectomy joint space supports both cellular and vascular ingrowth into human acellular dermal matrix.

Cited by 2 publications

References 24 publications

Viability of acellular biologic graft for nipple-areolar complex reconstruction in a non-human primate model

Viability of acellular biologic graft for nipple-areolar complex reconstruction in a non-human primate model

Engineered nanovesicles from stromal vascular fraction promote angiogenesis and adipogenesis inside decellularized adipose tissue through encapsulating growth factors

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