Abstract:Despite exercise being included in the recommended advice for patients with venous leg ulcers, there is a fear shared by clinicians and patients that exercise may be either inappropriate or harmful and actually delay rather than promote healing. Therefore, before implementing a larger-scale study exploring the effects of a supervised exercise programme in patients with venous ulcers being treated with compression therapy, it is important to assess exercise safety as well as fidelity and progression in a feasib… Show more
“…After excluding 135 duplicate studies and ineligible studies (77 reviews, 18 case reports, 3 animal studies, 18 conference abstracts, 172 irrelevant records), a total of 100 studies were evaluated for eligibility in the next step of screening. After full‐text review of 28 articles, we finally identified eight randomised control studies that met the inclusion criteria, including a total of 270 patients with diagnosed VLU 32‐39 . Details on literature search is depicted in Figure 1.…”
Section: Resultsmentioning
confidence: 99%
“…After full‐text review of 28 articles, we finally identified eight randomised control studies that met the inclusion criteria, including a total of 270 patients with diagnosed VLU. 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 Details on literature search is depicted in Figure 1 . The year of publication for included studies ranged from 2010 to 2022.…”
Section: Resultsmentioning
confidence: 99%
“…In the current meta-analysis, the pooled proportion of participants adherent to exercise regimen was 64% (95% CI: 53%, 75%), patients in these studies received clear direction and tutorials on exercise schedule and performance, and were supervised by investigators to improve the compliance with the regimens. [32][33][34]38 Moreover, results of evaluation for Egger's tests suggested nonsignificant publication bias in enrolled studies.…”
To determine the effects of exercise on VLU healing and exercise adherence, and to provide evidence for clinical practice and scientific investigation. PubMed, Embase and Scopus were searched from inception to 31st March, 2022. Pooled relative risks (RRs), standardised mean differences (SMDs), adherence rate with respective 95% confidence intervals (CIs) were calculated. Quality assessment of included studies were performed using the Cochrane Collaboration risk of bias evaluation. Heterogeneity between enrolled studies was evaluated. We identified eight randomised control studies (RCTs) that met the inclusion criteria. The pooled RR for healing rate was 1.38 (95% CI: 1.14 to 1.66; P = 0.0008) with no significant heterogeneity between component studies (I2 = 0%, P = 0.96). SMD for differences of total range of ankle joint motion (ROAM) at the end and at the initiation of follow‐up in the intervention and control groups was 0.87 (95% CI: 0.22, 1.52; P = 0.0091), no significant heterogeneity was detected (I2 = 59%, P = 0.0622). Pooled adherence rate was 64% (95% CI: 53%, 75%) with no significant heterogeneity. Exercise manifested positive effects on VLU healing, range of ankle mobility compared with the control group. Patients' adherence to the exercise regimens was favourable.
“…After excluding 135 duplicate studies and ineligible studies (77 reviews, 18 case reports, 3 animal studies, 18 conference abstracts, 172 irrelevant records), a total of 100 studies were evaluated for eligibility in the next step of screening. After full‐text review of 28 articles, we finally identified eight randomised control studies that met the inclusion criteria, including a total of 270 patients with diagnosed VLU 32‐39 . Details on literature search is depicted in Figure 1.…”
Section: Resultsmentioning
confidence: 99%
“…After full‐text review of 28 articles, we finally identified eight randomised control studies that met the inclusion criteria, including a total of 270 patients with diagnosed VLU. 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 Details on literature search is depicted in Figure 1 . The year of publication for included studies ranged from 2010 to 2022.…”
Section: Resultsmentioning
confidence: 99%
“…In the current meta-analysis, the pooled proportion of participants adherent to exercise regimen was 64% (95% CI: 53%, 75%), patients in these studies received clear direction and tutorials on exercise schedule and performance, and were supervised by investigators to improve the compliance with the regimens. [32][33][34]38 Moreover, results of evaluation for Egger's tests suggested nonsignificant publication bias in enrolled studies.…”
To determine the effects of exercise on VLU healing and exercise adherence, and to provide evidence for clinical practice and scientific investigation. PubMed, Embase and Scopus were searched from inception to 31st March, 2022. Pooled relative risks (RRs), standardised mean differences (SMDs), adherence rate with respective 95% confidence intervals (CIs) were calculated. Quality assessment of included studies were performed using the Cochrane Collaboration risk of bias evaluation. Heterogeneity between enrolled studies was evaluated. We identified eight randomised control studies (RCTs) that met the inclusion criteria. The pooled RR for healing rate was 1.38 (95% CI: 1.14 to 1.66; P = 0.0008) with no significant heterogeneity between component studies (I2 = 0%, P = 0.96). SMD for differences of total range of ankle joint motion (ROAM) at the end and at the initiation of follow‐up in the intervention and control groups was 0.87 (95% CI: 0.22, 1.52; P = 0.0091), no significant heterogeneity was detected (I2 = 59%, P = 0.0622). Pooled adherence rate was 64% (95% CI: 53%, 75%) with no significant heterogeneity. Exercise manifested positive effects on VLU healing, range of ankle mobility compared with the control group. Patients' adherence to the exercise regimens was favourable.
“…The research team involved in the evaluative work did not have influence over the content of the sessions delivered, as this was an existing community-based Public Health initiative. A worthwhile aspect for the Vitality program would be to consider evaluating the exercise progression and fidelity of new but also existing members, which has occurred in other exercise interventions for older adults [ 43 ]. It should be acknowledged that whilst participants in both the VP and CON groups were instructed not to participate in any additional daily physical activity, this was not monitored during the study period.…”
Community-based group physical activity programs promote exercise opportunities for older people. The aim of this study was to examine the short-term, new participant effect after joining Vitality, a community-based group physical activity program available in the East of England for older adults. Two independent groups of participants were assessed before and after an 8 week period: a group recruited from the ‘Vitality’ program (VP) (n 15, age: Age = 69.4 ± 6.4 y), and; a non-intervention control (CON) group (n 14, age: 64.5 ± 5.8 y). Assessment outcomes included basic physical health measures, a fitness test battery, and three psychological scales. The VP group recorded statistically significant improvements on the following outcomes: body mass (VP: −1.39 kg/CON: −0.2 kg), body mass index (VP: −1.5 kg/CON: −0.2 kg), 6 min walk (VP: +42.81 m/CON: −0.45 m), 30 s sit-to-stand (VP: −1.7 s/CON: −0.7 s), the chair sit-and-reach (VP: +3.12 cm/CON: +1.90 cm), and the 30 s arm curl test (VP: + 2 reps/CON: +0.9 reps). No significant differences were found with the other outcomes assessed. New members to the Vitality program achieved several physical and functional benefits without regression on any aspects of physical or psychological health.
Background
Venous leg ulcers heal slowly, are painful and costly for healthcare systems, and also affect patients’ quality of life.
Previous work suggests that supervised exercise training used in combination with compression therapy may offer clinical benefits. However there is a large population of people with VLUs, who are unable to access such an intervention due to frailty and age.
Objective
Our primary aim was to assess the feasibility of FISCU Home (a co-designed, 12-week home-based, self-managed, lifestyle programme based on exercise and behaviour support), as an adjunct therapy to compression in people with VLUs.
Methods
Forty people with VLUs (121 excluded/22 refused), receiving treatment at home, were recruited from community nursing and tissue viability teams and newspaper advertisement.
Participants were randomized 1:1 either to exercise with behaviour support (thrice/week) plus compression therapy or compression only. The feasibility of the programme was assessed using progression criteria that included exercise attendance rate, loss to follow-up, patient preference(s) and adverse events. Baseline assessments were repeated at 12 weeks and 6 months. Secondary outcomes (i.e., ulcer recurrence, healing rate and healing time) were also documented at these intervals. Intervention and healthcare utilization costs were calculated.
Results
Recruitment rate was 65%, while 75% of the exercise group participants attended all scheduled exercise sessions. All participants completed their compression therapy. No serious adverse or exercise-related adverse events were reported. Median ulcer healing time was shorter in the exercise group (29 (7-108) vs 42 (6-116) weeks).
Conclusions
The feasibility and acceptability of both a home-based, exercise-based, lifestyle intervention in conjunction with compression therapy, and the study procedures are supported.
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