Physicochemical Characterization and Antinociceptive Effect of β-cyclodextrin/Lippia pedunculosa Essential Oil in Mice

Menezes, Paula dos Passos; Araujo, Francielly de Oliveira; Andrade, Tatianny A.; Trindade, Igor Araújo Santos; Araújo-Filho, Heitor G.; Quintans, Jullyana de Souza Siqueira; Quintans‐Júnior, Lucindo J.; Menezes, Leociley Rocha Alencar; Almeida, Reinaldo Nóbrega de; Braga, Renan Marinho; Serafini, Mairim Russo; Costa, Emmanoel V.; Araújo, Adriano Antunes de Souza

doi:10.2174/1568026618666180607081742

Cited by 4 publications

(4 citation statements)

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“…Araujo-Filho et al, (2017) recently demonstrated that β-CD improves the analgesic effect of D-limonene. Thus, the weak effect found for EOLp/β-CD may be due to stereo-chemical difficulties in rotundifolone cavity or surface complexing with β-CD (Lima et al, 2016;Menezes et al, 2018).…”

Section: Boletín Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromáticas / 169mentioning

confidence: 99%

“…Several studies have attempted to improve the pharmacological profile of Lippia species essential oils using a β-CD inclusion complexes (Fernandes et al, 2004;Marreto et al, 2008;Arana-Sánchez et al, 2010;Siqueira-Lima et al, 2014). Our collaborators started the evaluation of the analgesic profile of EOLp with a preliminary formalin test which indicated a possible antinociceptive effect (Menezes et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Antinociceptive and anti-inflammatory effect of Lippia pedunculosa Hayek essential oil and its β-cyclodextrin inclusion complex

Braga¹,

Andrade²,

Neto³

et al. 2021

BLACPMA

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Lippia pedunculosa Hayek (EOLp) presents tripanocid and amebicid effects. However essential oil needs to be further studied in experimental models of analgesia and inflammation once the prevalence of pain in the population generates great suffering and disability and the drugs most often used have undesirable side effects. We also evaluated whether the inclusion complex formulation EOLp/β-cyclodextrin (β-CD) was able to improve the antinociceptive activity of the EOLp alone. Data were evaluated by analysis of variance (ANOVA), followed by Tukey’s test. Differences were considered significant if p<0.05. EOLp presented better antinociceptive effect when compared to the EOLp/β-CD inclusion complex. Thus, cyclodextrins appear not to be efficient for essential oils with peroxide substances. However, in peritonitis, EOLp reduced total leucocyte migration and IL-1β levels in the peritoneal fluid, which confirmed its anti-inflammatory effect. The observed effects suggest that EOLp is the best promising option for the treatment of inflammation and pain-related disorders.

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Section: Boletín Latinoamericano Y Del Caribe De Plantas Medicinales Y Aromáticas / 169mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antinociceptive and anti-inflammatory effect of Lippia pedunculosa Hayek essential oil and its β-cyclodextrin inclusion complex

Braga¹,

Andrade²,

Neto³

et al. 2021

BLACPMA

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“…This behavior revealed the interaction between essential oil and β-CD and the accomplishment of encapsulation. In other works of literature, Croton rhamnifolioides essential oil [44], Lippia pedunculosa essential oil [45], and Exocarpium Citri Grandis essential oil [6] complexed with cyclodextrins, respectively, the morphology and particle sizes of inclusion complexes were transformed compared to pure β-CD. Multiple morphologies of various inclusion complexes can be observed, which may be based on the admitting ability of the β-CD cavity on various guest molecules to encapsulation.…”

Section: Morphological Detectionmentioning

confidence: 99%

Preparation, Optimization, and Characterization of Inclusion Complexes of Cinnamomum longepaniculatum Essential Oil in β-Cyclodextrin

et al. 2022

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Cinnamomum longepaniculatum essential oil (CLEO) possesses antibacterial, anti-inflammatory, and antioxidant activities. However, CLEO shows volatilization and poor solubility, which limits its application field. In this research, inclusion complexes of β-cyclodextrin (β-CD) with CLEO were produced, and its physicochemical properties were characterized. Response surface methodology was used to obtain optimum preparation conditions. A statistical model was generated to define the interactions among the selected variables. Results show that the optimal conditions were an H2O/β-CD ratio of 9.6:1 and a β-CD/CLEO ratio of 8:1, with the stirring temperature of 20 °C for the maximal encapsulation efficiency values. The physicochemical properties of CLEO/β-CD inclusion complexes (CLEO/β-CD-IC) were investigated. Fourier transform infrared spectroscopy showed that correlative characteristic bands of CLEO disappeared in the inclusion complex. X-ray diffraction presented different sharp peaks at the diffraction angle of CLEO/β-CD-IC. The thermogravimetric analysis demonstrated the thermal stability of CLEO was enhanced after encapsulation. Tiny aggregates with a smaller size of CLEO/β-CD-IC particles were observed by scanning electron microscopy. The comparison of β-CD, CLEO, and physical mixtures with CLEO/β-CD-IC confirmed the formation of inclusion complexes.

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“…Formed in plant secondary metabolism, they act as a form of protection against predatory attacks, to attract pollinators, and have many other activities. The great structural variety of substances present in EOs is one of the factors responsible for their various pharmacological activities, including anxiolytic [12], antidepressant [13], anticonvulsant [14,15], and antinociceptive effects [16][17][18][19][20]. Some of these activities are attributed to the intensification of GABAergic transmission due the interaction of monoterpenes with GABA A receptors [21].…”

Section: Introductionmentioning

confidence: 99%

Involvement of GABAA Receptors in the Anxiolytic-Like Effect of Hydroxycitronellal

Andrade

Monteiro

Andrade

et al. 2021

BioMed Research International

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Hydroxycitronellal (HC) is a monoterpene present in essential oils of aromatic plants of different species, obtained from semisynthesis of citronellal, and is widely used as a fragrance in cosmetics. The objective of this work was to evaluate the possible anxiolytic-like activity of HC and its possible mechanism of action using in vivo and in silico methodologies. Swiss male mice (Mus musculus) were treated with HC (12.5, 25, and 50 mg/kg, i.p.) and subjected to the rota rod, elevated plus maze, and open field tests. No significant impairments were observed in the rota rod tests for the motor activity of the animals treated with HC at 12.5, 25, and 50 mg/kg, i.p., indicating no myo-relaxing or sedative effects. In the elevated plus maze, HC (in the three doses) induced significant increases in the percentage of entries (respectively, 34.8%, 33.8%, and 38.6%) and in the length of stay (respectively, 49.9%, 56.1%, and 57.0%) in the open arms of the EPM, as well as the number of crossings in the open field tests. The mechanism of action of the compound’s anxiolytic-like activity can be attributed to the involvement of GABAA receptors, and this interaction was observed in in vivo and in silico studies. For HC, the results suggest anxiolytic-like effects, possibly via modulation of the GABAergic system. The use of natural products to treat anxiety can become an alternative to existing synthetic products.

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Physicochemical Characterization and Antinociceptive Effect of β-cyclodextrin/Lippia pedunculosa Essential Oil in Mice

Abstract: Therefore, CDs seem not to be a good tool to enhance the pharmacological properties of EOs rich in peroxide compounds such as rotundifolone.

Cited by 4 publications

References 0 publications

Antinociceptive and anti-inflammatory effect of Lippia pedunculosa Hayek essential oil and its β-cyclodextrin inclusion complex

Antinociceptive and anti-inflammatory effect of Lippia pedunculosa Hayek essential oil and its β-cyclodextrin inclusion complex

Preparation, Optimization, and Characterization of Inclusion Complexes of Cinnamomum longepaniculatum Essential Oil in β-Cyclodextrin

Involvement of GABAA Receptors in the Anxiolytic-Like Effect of Hydroxycitronellal

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