“…39 The ability to categorize patients' trajectories of risk has potential implications for further research examining the effectiveness of intensive management interventions for patients at high risk of adverse outcomes, where most randomized trials have not shown significant benefits. For example, VA investigators conducted two randomized evaluations of an intensive, multidisciplinary, team-based approach for veterans with high hospitalization probability, as predicted by the CAN model, and showed no reduction in use of acute care or total healthcare 40,41 Future research should ascertain whether these programs exhibit variable effects on patients with different expected risk trajectories, characterized using baseline characteristics identified in this study. This study has several limitations.…”