Different modalities of exercise improve macrovascular function but not microvascular function in metabolic syndrome: The RESOLVE randomized trial

Vinet, Agnès; Obert, Phillippe; Courteix, Daniel; Chapier, Robert; Lesourd, B.; Verney, Julien; Dutheil, Frédéric; Walther, Guillaume

doi:10.1016/j.ijcard.2018.05.073

Cited by 15 publications

(11 citation statements)

References 23 publications

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“…Opinions differ over the exercise modalities that best limit cardiovascular risk [ 75 ]. In patients with metabolic syndrome, it has been shown that mixed training with high-intensity increased visceral fat loss, and that training with high-resistance intensity resulted in faster improvement [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of exercise training on heart rate variability in type 2 diabetes mellitus patients: A systematic review and meta-analysis

et al. 2021

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Background Cardiac autonomic neuropathy is a common complication of type 2 diabetes mellitus (T2DM), that can be measured through heart rate variability (HRV)–known to be decreased in T2DM. Physical exercise can improve HRV in healthy population, however results are under debate in T2DM. We conducted a systemic review and meta-analysis to assess the effects of physical exercise on HRV in T2DM patients. Method PubMed, Cochrane, Embase, and ScienceDirect databases were searched for all studies reporting HRV parameters in T2DM patients before and after exercise training, until September 20th 2020, without limitation to specific years. We conducted random-effects meta-analysis stratified by type of exercise for each of the HRV parameters: RR–intervals (or Normal to Normal intervals–NN), standard deviation of RR intervals (SDNN), percentage of adjacent NN intervals varying by more than 50 milliseconds (pNN50), root mean square of successive RR-intervals differences (RMSSD), total power, Low Frequency (LF), High Frequency (HF) and LF/HF ratio. Sensitivity analyses were computed on studies with the highest quality. Results We included 21 studies (9 were randomized) for a total of 523 T2DM patients: 472 had an exercise training and 151 were controls (no exercise). Intervention was endurance (14 studies), resistance (2 studies), endurance combined with resistance (4 studies), and high intensity interval training (HIIT) (4 studies). After exercise training, all HRV parameters improved i.e. an increase in SDNN (effect size = 0.59, 95%CI 0.26 to 0.93), RMSSD (0.62, 0.28 to 0.95), pNN50 (0.62, 0.23 to 1.00), HF (0.58, -0.16 to 0.99), and a decrease in LF (-0.37, -0.69 to -0.05) and LF/HF (-0.52, -0.79 to -0.24). There were no changes in controls. Stratification by type of exercise showed an improvement in most HRV parameters (SDNN, RMSSD, pNN50, LF, HF, LF/HF) after endurance training, whereas mostly LF/HF was improved after both resistance training and HIIT. Supervised training improved most HRV parameters. Duration and frequency of training did not influence the benefits on HRV. Conclusion Exercise training improved HRV parameters in T2DM patients which may reflect an improvement in the activity of the autonomic nervous system. The level of proof is the highest for endurance training. Supervised training seemed beneficial.

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Section: Discussionmentioning

confidence: 99%

Effect of exercise training on heart rate variability in type 2 diabetes mellitus patients: A systematic review and meta-analysis

et al. 2021

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“…As the sample of ethnic groups were healthy, we speculate that the muscular stress induced by our CT intervention that included both resistant training (inducing a muscle stress into a time) as well as HIIT that could promote more muscle mass stimulation and thus improving more the vasculature for blood pressure decreases. A possible mechanism responsible for the training‐induced improved blood pressure profile is a reduced peripheral vascular resistance, which in turn can be achieved through improved vascular function in large vessels and increased capillary and arteriolar angiogenesis …”

Section: Discussionmentioning

confidence: 99%

Improvements cardiometabolic risk factors in Latin American Amerindians (the Mapuche) with concurrent training

Álvarez

Ramírez‐Vélez

Ramírez‐Campillo

et al. 2019

Scandinavian Med Sci Sports

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Our aim was to investigate the effects of 12 weeks of CT (ie, high-intensity interval and resistance training) in Mapuche adults from Chile and in their peers of European descent. In total, 96 hyperglycemic adult women (mean age 46 years [95% confidence interval; 38, 53]) were divided in four groups: Mapuche CT (Map-CT, n = 14) or control group (Map-CG, n = 44), and European CT (Eur-CT, n = 14) or control group (Eur-CG, n = 23). The following endpoints were analyzed at baseline and after 12 weeks: anthropometric (body mass, body mass index, waist circumference), body composition (fat mass, muscle mass, lean mass), cardiovascular (systolic [SBP]/diastolic [DBP] blood pressure), metabolic (blood fasting glucose and total cholesterol), and muscle strength (handgrip of dominant/non-dominant arm). There were significant positive changes in body mass, body fat, and muscle mass (P < 0.0001) in both Map-CT and Eur-CT groups, whereas waist circumference was decreased significantly only in the Eur-CT group (P < 0.0001). Both Map-CT and Eur-CT groups showed decreased levels of fasting glucose (P < 0.05) and total cholesterol after the intervention (P < 0.0001). Also, both Map-CT (P < 0.05) and Eur-CT (P = 0.01) groups showed a lowered SBP. Finally, significant increases were observed after training in handgrip strength (dominant arm) in Map-CT and Eur-CT groups (both P < 0.0001). CT led to similar improvements in cardiometabolic risk factors for metabolic syndrome development in Mapuche and European participants, with additional improvements in other anthropometric, body composition, cardiovascular, metabolic, and muscle strength parameters related to the prevention of metabolic syndrome. These results suggest future more complex studies. K E Y W O R D S concurrent training, ethnicity, European, Mapuche Amerindians, risk factors | 887 ÁLVAREZ Et AL.

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“…This study demonstrated that long-term aerobic exercise training in adolescents is associated with enhanced skin MVR (Roche et al, 2008). Vinet et al (2018) found that any exercise modality improved flow mediated dilation in those with metabolic syndrome. Exercise modalities included high intensity resistance training, aerobic training, or a combination of the both (Vinet et al, 2018).…”

Section: Introductionmentioning

confidence: 56%

“…Vinet et al (2018) found that any exercise modality improved flow mediated dilation in those with metabolic syndrome. Exercise modalities included high intensity resistance training, aerobic training, or a combination of the both (Vinet et al, 2018). Goto et al (2003) investigated the effect of intensity of exercise on endothelium dependent vasodilatation.…”

Section: Introductionmentioning

confidence: 94%

The Effect of High Intensity Interval Training Versus Steady State Aerobic Training on Skin Microvascular Reactivity in Moderately Active Young Adults: A Pilot Study

Naicker¹,

Sookan²

2019

GJHS

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A sedentary lifestyle is associated with endothelial dysfunction, leading to vascular pathology and impaired microvascular reactivity (MVR). Enhanced endothelial functioning has been seen in aerobically trained individuals. The purpose of this study was to determine if there was a differential training response of skin MVR in response to high intensity aerobic interval training (HIAIT) as compared to steady state aerobic training (SSAT). The study involved 16 moderately active male students (age: 20.93 ± 5.05 yrs). They were randomly assigned to one of three groups; HIAIT, SSAT, and control group (CG). Baseline testing was performed to determine the VO2max, lactate threshold, blood pressure, body composition and a post-occlusive reactive hyperemia response (PORH) test was used to assess microvascular reactivity on the right palmer forearm using a moorVMS-Laser Doppler Flowmetry (LDF) These parameters were reassessed after three weeks (mid-point) and six-weeks (post intervention) weeks. Statistical significance was set at p≤0.05. There were no significant interactions between the variables measured in the three groups over time. There was a positive linear relationship in the SSAT group for PORHmax/time to peak (Tp) at baseline (r = 0.998, p = 0.039), midpoint (r = 0.992, p = 0.083), and the post intervention (r = 0.987, p = 0.103). Training in the SSAT group had improved PORHpeak at midpoint and post intervention time points (r = 0.999, p = 0.22; r = 1, p = 0.006; r = 1, p = 0.011). Training in either the HIAIT or the SSAT group had no significant effect on skin MVR in moderately active young adults. SSAT did display a positive linear relationship with PORHmax/Tp, and PORHpeak, which are variables influencing skin MVR.

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Different modalities of exercise improve macrovascular function but not microvascular function in metabolic syndrome: The RESOLVE randomized trial

Cited by 15 publications

References 23 publications

Effect of exercise training on heart rate variability in type 2 diabetes mellitus patients: A systematic review and meta-analysis

Effect of exercise training on heart rate variability in type 2 diabetes mellitus patients: A systematic review and meta-analysis

Improvements cardiometabolic risk factors in Latin American Amerindians (the Mapuche) with concurrent training

The Effect of High Intensity Interval Training Versus Steady State Aerobic Training on Skin Microvascular Reactivity in Moderately Active Young Adults: A Pilot Study

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