Prognostic Factors, Survival, and Treatment for Intracranial World Health Organization Grade II Chordoid Meningiomas and Clear-Cell Meningiomas

Zhang, Guijun; Zhang, Yunsheng; Zhang, Guobin; Yan, Xiu-Juan; Li, Cheng-Bei; Zhang, Liwei; Li, Da; Wu, Zhen; Zhang, Junting

doi:10.1016/j.wneu.2018.04.226

Cited by 19 publications

(18 citation statements)

References 17 publications

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“…Zhang et al reviewed all the reported cases of intracranial CCMs (16) and spinal CCMs (17), and they found a significant female predilection in spinal CCMs. The female-to-male ratio was 1.4:1.0 in the present study, which is consistent with previous reports (11,18). Louis et al proposed that CCMs are more likely to affect young patients, including children and young adults (1).…”

Section: Discussionsupporting

confidence: 93%

“…According to Zhang's review, 42.9% of patients with spinal CCMs were younger than 18 years old (17), and the mean age at surgery was 24 and 32 years old for spinal and intracranial CCMs, respectively (16,17). However, the predilection for the young population was not remarkable in some reports (18). In the present cohort, the mean age was 50.77 ± 17.648 years old (median age: 52 years old), most of the patients were diagnosed (19).…”

Section: Discussionmentioning

confidence: 99%

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Clear Cell Meningioma in the Central Nervous System: Analysis of Surveillance, Epidemiology, and End Results Database

Wang

Qin

et al. 2021

Front. Oncol.

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BackgroundClear cell meningioma (CCM) is a rare subtype of meningioma, accounting for approximately 0.2% of all meningiomas. The present study aimed to analyze the epidemiology and outcome of CCMs using the Surveillance, Epidemiology, and End Results (SEER) database.MethodsPatients diagnosed with central nervous system CCM between 2004 and 2016 were identified from the SEER database. Descriptive analyses were performed to evaluate the distribution of patients and tumor-related characteristics. The survival analysis was performed using Kaplan-Meier curves. The Cox proportional hazards model was used for the univariate and multivariate analyses.ResultsThe age-adjusted incidence rate was 0.032 per 1,000,000 person-years. The median age was 52 years. Most of the CCMs were intracranial CCMs that were larger than 3 cm. The overall cumulative survival rates at 1, 3, and 5 years were 97.6, 93.2, and 86.9%, respectively. The log‐rank test and Cox proportional hazards regression analysis revealed that age at diagnosis and primary site of the tumor were independent prognostic factors.ConclusionCCM is an extremely rare entity with a favorable survival rate. CCMs usually affect patients during the fourth to fifth decades of life. Patients diagnosed at 21–60 years old and patients with spinal CCMs have a better prognosis.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Clear Cell Meningioma in the Central Nervous System: Analysis of Surveillance, Epidemiology, and End Results Database

Wang

Qin

et al. 2021

Front. Oncol.

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“…5 On the other hand, 5% occur along the cerebellar convexity, 2 to 4% at the tentorium cerebelli, and 2 to 4% within the cerebellopontine angle (CPA). 6 Chordoid meningioma is an uncommon histopathological variant of meningioma frequently mistaken as chordoma, due to its histological similarity. Couce et al related 42 clinicopathologic studies about CM during the period of 1975 to 1997, and this study concluded that it was more common in the supratentorial region and in adults.…”

Section: Resultsmentioning

confidence: 99%

“…Couce et al related 42 clinicopathologic studies about CM during the period of 1975 to 1997, and this study concluded that it was more common in the supratentorial region and in adults. 6,7 There are only two studies about genetic alterations in CMs. The majority of meningiomas is known to have deletion at many chromosomal loci not yet studied in CMs, such as 22q, 18p, 14q and 1p.…”

Section: Resultsmentioning

confidence: 99%

Chordoid Meningioma: Literature Review

Massella¹,

Morais²,

Figueiredo³

et al. 2020

Arq Bras Neurocir

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Chordoid meningiomas (CMs) are a rare subgroup of tumors, accounting for ∼ 0.5% of all meningiomas. Chordoid meningioma tumors correspond to World Health Organization (WHO) Grade II lesions and behave aggressively, with an increased likelihood of recurrence. There are few genetic studies about CMs, but we understand that there is deletion at many chromosomal loci. Histologically, CMs are characterized by strands and cords of meningothelial cells arranged in a mucinous stroma. Morphologically, it can mimic other chondroid and myxoid tumors within the brain and its vicinity, thus posing a diagnostic challenge. Chordoid meningiomas have an aggressive clinical course and a propensity to recur compared with classical meningiomas. The goal of the treatment is surgery, with total resection of the tumor; however, due to its high degree of recurrence, radiotherapy is often necessary as an adjuvant treatment.

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“…Other factors concerned with unfavorable overall results were presented by Zhang, et al [32]. In this large retrospective analysis, male gender, larger tumor size, surgical history and bone invasion were defined as risk factors associated with poor outcome.…”

Section: Significant Chordoidmentioning

confidence: 88%

Chordoid Meningioma: Case Report and Review of the Literature

Prokopienko¹,

Wierzba-Bobrowicz²,

Grajkowska³

et al. 2020

Neurosurg Cases Rev

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Chordoid meningioma is an uncommon histopathological type of meningioma, frequently associated with Castleman's syndrome. Histologically, chordoid meningiomas are similar to chordomas. Because of their high proliferative index, they present aggressive biological behavior and high risk of postoperative recurrence. We report a case of choroid meningioma in adult patient without Castleman's syndrome manifestation. As its chordoid features is related with a rapid recurrence after incomplete removal, meticulous histopathological examination is crucial for the adequate postoperative treatment plan.

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Prognostic Factors, Survival, and Treatment for Intracranial World Health Organization Grade II Chordoid Meningiomas and Clear-Cell Meningiomas

Cited by 19 publications

References 17 publications

Clear Cell Meningioma in the Central Nervous System: Analysis of Surveillance, Epidemiology, and End Results Database

Clear Cell Meningioma in the Central Nervous System: Analysis of Surveillance, Epidemiology, and End Results Database

Chordoid Meningioma: Literature Review

Chordoid Meningioma: Case Report and Review of the Literature

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