Females have stronger neurogenic response than males after non-specific nasal challenge in patients with seasonal allergic rhinitis

Tomljenovic, Dejan; Baudoin, Tomislav; Megla, Željka Bukovec; Geber, Goran; Scadding, Glenis K.; Kalogjera, Livije

doi:10.1016/j.mehy.2018.04.021

Cited by 15 publications

(21 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent research of the interaction between chronic stress and severity of chronic rhinosinuitis (CRS) in a disease specific questionnaire, has shown significant association of CRS severity and chronic stress. (Tomljenovic, 2018). We, however, were unable to confirm these previously reported gender differences in stress induced inflammatory responses in this paper.…”

Section: Discussioncontrasting

confidence: 92%

See 1 more Smart Citation

Recovery From Sudden Sensorineural Hearing Loss May Be Linked to Chronic Stress Levels and Steroid Treatment Resistance

et al. 2019

Self Cite

View full text Add to dashboard Cite

Purpose: This paper investigates the possible connections between the level of chronic stress and success of steroid therapy in patients with sudden sensorineural hearing loss (SSNHL). Method: A single-center retrospective longitudinal cohort study on 55 patients in a tertiary referral otology center. Patients diagnosed with SSNHL between 2014 and 2017 were asked to complete a Measure of Perceived Stress (MPS) questionnaire. Inclusion criteria were patients >18 years of age, SSNHL diagnosed within 4 previous weeks, completed steroid treatment, and complete documentation. Results: There were 30 patients (55%) that showed significant improval in their pure tone audiogram (PTA) hearing threshold average (≥15 dB) after steroid treatment. Two-step cluster analysis identified three clusters based on average PTA hearing threshold recovery and average MPS scores. The difference between pre-treatment and post-treatment hearing levels was significantly higher in the cluster with moderate stress compared to clusters with mild and high stress levels (Kruskal-Wallis test, Friedman test, P<0.001). There were no significant differences in average PTA hearing threshold recovery after steroid therapy between groups of patients with mild and severe stress. Conclusions: Patients with moderate stress levels show significantly better results after steroid treatment for SSNHL than patients with low or high stress levels.

show abstract

Section: Discussioncontrasting

confidence: 92%

“…Also, interactions between chronic stress and severity of chronic rhinosinuitis (CRS) have shown significant association between CRS severity and chronic stress levels. (Tomljenovic, 2018).…”

Section: Introductionmentioning

confidence: 99%

Recovery From Sudden Sensorineural Hearing Loss May Be Linked to Chronic Stress Levels and Steroid Treatment Resistance

et al. 2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…We found that differences between post-allergen and post–hypertonic saline provocation was highly significant in female patients, as opposed to male patients. 12…”

Section: Discussionmentioning

confidence: 99%

Redefining Pregnancy-Induced Rhinitis

Baudoin

Šimunjak

Bacan

et al. 2020

Am J Rhinol�Allergy

Self Cite

View full text Add to dashboard Cite

Background Pregnancy-induced rhinitis (PIR) is a form of chronic non-allergic rhinitis not present before pregnancy that manifests itself during pregnancy with complete resolution of symptoms after delivery. Objective The objective of this ambidirectional longitudinal cohort study is to evaluate the prevalence of PIR and to investigate the appearance and character of its symptoms, and its impact on the quality of life. Methodology: Six hundred eighty-one (681) women were recruited in the study. They completed questionnaires about nasal symptoms a day after delivery and each woman with nasal symptoms was interviewed 30 days later and data on symptom duration and quality were recorded. Results The prevalence of PIR was 31.86% (N = 217), 47.14% (N = 321) women had no nasal symptoms and 21% (N = 143) of participants had prior sinonasal disease. The clinical presentation of pregnancy rhinitis included nasal obstruction as the most common symptom, followed by rhinorrhea, postnasal secretion, nose itching, sneezing, and hyposmia. The median duration of PIR was 4 months with their complete resolution of symptoms between 2th and 16th day after delivery in the majority of respondents. PIR was diagnosed significantly more often if the women carried a female child. PIR affected their quality of life during pregnancy in 53,9% women (N = 117), with an average VAS score of 8. It seems that pregnancy may affect the course of previously present sinonasal disease (allergic rhinitis, chronic rhinosinusitis, nonallergic rhinitis, or non-infectious rhinitis prior to the pregnancy). Conclusions PIR is a common clinical entity with a wide range of symptoms with a direct impact on the quality of life in pregnancy. We propose a new definition of pregnancy-induced rhinitis.

show abstract

“…For instance, atopy, parasympathetic hyperactivity, and elevated neuropeptide secretion contribute to both asthma and migraines 22 . Allergic responses triggered by allergens, such as specific grass, pollen, and even hypertonic saline, evoke airway hypersensitivity responses mediated by mast cells in asthmatic patients 23 . In migraines, mast cells in the dura, which are activated by allergens, are presumed to excite meningeal nociceptors and initiate the activation of nearby trigeminal afferents 24 .…”

Section: Discussionmentioning

confidence: 99%

Bidirectional association between asthma and migraines in adults: Two longitudinal follow-up studies

Kim

Min

et al. 2019

Sci Rep

View full text Add to dashboard Cite

the objective of this study was to evaluate the bidirectional association between asthma and migraines using control subjects matched by demographic factors. the Korean Health insurance Review and Assessment Service-National Sample Cohort from 2002 to 2013 was used. In study I, 113,059 asthma participants were matched with 113,059 control I participants. In study II, 36,044 migraine participants were matched with 114,176 control II participants. The hazard ratios (HRs) of migraines in the asthma patients (study I) and asthma in the migraine patients (study II) were analyzed using stratified Cox proportional hazard models after adjusting for depression and the Charlson comorbidity index. In study I, 5.3% (6,017/ 113,059) of the asthma group and 3.4% (3,806/ 113,059) of the control I group had migraines (P < 0.001). The asthma group demonstrated an adjusted HR of 1.47 for migraine (95% confidence interval (CI) = 1.41-1.53, P < 0.001). In study II, 15.4% (5,548/36,044) of the migraine group and 10.6% (15,271/144,176) of the control group had asthma (P < 0.001). The migraine group showed an adjusted HR of 1.37 for asthma (95% CI = 1.33-1.41, P value < 0.001). Asthma and migraines are reciprocally associated. Asthma is a chronic airway disease associated with clusters of respiratory symptoms, including wheezing and dyspnea. Asthma is a common disease with different prevalences according to ethnicity that range from approximately 7% to 18.0% 1. The incidence of asthma in the adult population (>20 years old) was estimated to be approximately 3.63-6.07 per 1,000 people in Korea 2. Because the diagnosis of asthma is based on the functional deterioration of the lower airway, the underlying pathophysiologic causes of asthma have been reported to vary among asthmatic patients 3. According to the pathophysiologic mechanisms, asthma is classified as two major endotypes of T-helper type 2 cell (TH2)-high and TH2-low diseases 4. Thus, in addition to TH2-high related diseases, such as allergic rhinitis, other immune-related diseases could complicate asthma. In addition, both genetic factors and environmental triggering factors have been suggested to be related to asthma 5,6. Migraine disorder is another chronic disease characterized by multiple symptoms of headache and/or aura. As many as approximately 1.04 billion people suffer from migraines worldwide (95% uncertainty interval = 1.00-1.09) 7. In Korea, approximately 6.0% of the adult population (19-69 years) suffers from migraines 8. Migraines are characterized by recurrent episodic symptom sequences of a premonitory phase, an aura phase, a headache phase, and a postdrome phase 9. The environmental triggering factors can hyper-activate the hypothalamic-pituitary-adrenocortical axis and autonomic nervous system in migraine susceptible subjects 10. These hormonal and nervous changes induce vasodilation, the release of vascular factors, including growth factors, cytokines, nitric oxide, norepinephrine and calcitonin gene-related peptide, and interaction with endothelial cells, res...

show abstract

Females have stronger neurogenic response than males after non-specific nasal challenge in patients with seasonal allergic rhinitis

Cited by 15 publications

References 38 publications

Recovery From Sudden Sensorineural Hearing Loss May Be Linked to Chronic Stress Levels and Steroid Treatment Resistance

Recovery From Sudden Sensorineural Hearing Loss May Be Linked to Chronic Stress Levels and Steroid Treatment Resistance

Redefining Pregnancy-Induced Rhinitis

Bidirectional association between asthma and migraines in adults: Two longitudinal follow-up studies

Contact Info

Product

Resources

About