Correction: Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation

Bettoun, Audrey; Joffre, Carine; Zago, G.; Surdez, Didier; Vallerand, David; Gündoğdu, Ramazan; Sharif, Ahmad A.D.; Gómez, Marta; Cascone, Ilaria; Meunier, Brigitte; White, Michael A.; Codogno, Patrice; Parrini, Maria Carla; Camonis, Jacques; Hergovich, Alexander

doi:10.18632/oncotarget.25335

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, STK38 increases NOTCH1 (notch receptor 1) signaling activity by impairing Fbw7 (F-box and WD repeat domain-containing 7) mediated the degradation of NICD (notch intracellular domain) to enhance breast cancer stem cell properties [ 63 ]. Moreover, STK38 is required for anchorage-independent soft agar growth, and in vivo xenograft growth of Ras-transformed human cells, in which STK38 supports the Ras-induced transformation by promoting detachment-induced autophagy [ 64 ]. The expression level of inwardly rectifying potassium channel 2.1 (Kir2.1) is elevated in invasive gastric cancer cells.…”

Section: Involvement Of Stk38 In Malignancymentioning

confidence: 99%

The Role of Mammalian STK38 in DNA Damage Response and Targeting for Radio-Sensitization

Fukasawa

Enomoto

Yoshizaki‐Ogawa

et al. 2023

Cancers

View full text Add to dashboard Cite

Protein kinases, found in the nucleus and cytoplasm, play essential roles in a multitude of cellular processes, including cell division, proliferation, apoptosis, and signal transduction. STK38 is a member of the protein kinase A (PKA)/PKG/PKC family implicated in regulating cell division and morphogenesis in yeast and C. elegans. However, its function remained largely unknown in mammals. In recent years, advances in research on STK38 and the identification of its substrates has led to a better understanding of its function and role in mammals. This review discusses the structure, expression, and regulation of activity as a kinase, its role in the DNA damage response, cross-talk with other signaling pathways, and its application for radio-sensitization.

show abstract

Section: Involvement Of Stk38 In Malignancymentioning

confidence: 99%