The Predictive Factors Associated With Comorbidities for Treatment Response in Outpatients With King Classification III Diabetes Foot Ulcers

Su, C. C.; Chang, Chang‐Cheng; Peng, Yun-Shing; Chen, Mei‐Yen

doi:10.1097/sap.0000000000001500

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…However, this was only shown in univariable analysis. 30 Our study suggests that the chance to heal a wound is depended on whether the wound is deep or superficial. In our study, we have shown that a deeper wound, known as UT classification grade 2 and UT classification grade 3, is related to hard-to-heal wounds and that time to healing is negatively influenced by these two predictors.…”

Section: Discussionmentioning

confidence: 72%

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Outcome predictors for wound healing in patients with a diabetic foot ulcer

Zadeh

Lingsma

Neck

et al. 2019

International Wound Journal

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The aim of this study was to identify diabetic foot ulcer (DFU) patients at risk for the development of a hard‐to‐heal wound. This is a post‐hoc analysis of a prospective cohort study including a total of 208 patients with a DFU. The primary endpoints were time to healing and the development of a hard‐to‐heal‐wound. Univariable and multivariable logistic and Cox regression analysis were used to study the associations of patient characteristics with the primary endpoints. The number of previous DFUs [odds ratio (OR): 1.42, 95% confidence interval (CI): 1.01‐1.99, P = .04], University of Texas (UT) classification grade 2 (OR: 2.93, 95% CI: 1.27‐6.72, P = .01), UT classification grade 3 (OR: 2.80, 95% CI: 1.17‐6.71, P = .02), and a diagnosis of foot stand deformation (OR: 1.54, 95% CI: 0.77‐3.08, P = .05) were significantly associated with the development of a hard‐to‐heal wound. Only UT classification grade 3 (HR: 0.61, 95% CI: 0.41‐0.90, P = .01) was associated with time to healing. The number of previous DFUs, UT classification grade, and a diagnosis of foot deformation are significantly associated with development of a hard‐to‐heal wound in patients with a DFU. The only predictor significantly associated with time to healing was UT classification grade 3. These patient characteristics can be used to identify patients at risk for the development of hard‐to‐heal wounds, who might need an early intervention to prevent wound problems.

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Section: Discussionmentioning

confidence: 72%

“…A recent study also suggested a predictive role for previous percutaneous transluminal angioplasty or retinopathy for treatment failure in patients with a DFU. However, this was only shown in univariable analysis …”

Section: Discussionmentioning

confidence: 92%

Outcome predictors for wound healing in patients with a diabetic foot ulcer

Zadeh

Lingsma

Neck

et al. 2019

International Wound Journal

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Mean Platelet Volume-to-Lymphocyte Ratio Is a Biomarker of 1-Year Mortality in Patients With Diabetic Foot Infections

Aragón‐Sánchez

Víquez-Molina²,

López-Valverde

et al. 2023

The International Journal of Lower Extremity Wounds

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We aimed to evaluate the value of 2 peripheral blood cell ratios, the mean platelet volume-to-lymphocyte ratio (MPVLR) and the neutrophil-to-lymphocyte ratio (NLR) as prognostic biomarkers of mortality in patients with diabetic foot infections (DFIs). We conducted a prospective observational study consisting of a cohort of 200 patients with moderate to severe DFIs consecutively recruited from our Diabetic Foot Unit, Hospital San Juan de Dios, San José de Costa Rica, Costa Rica from October 15, 2020, to December 15, 2021. We studied the variables associated with one-year all-cause mortality using a multivariate backward Cox’s regression model. Nonparametric Spearman Rho was used to study the linear correlation between NLR and MPVLR and other inflammatory markers. The variables associated with all-cause mortality were retinopathy (hazard ratio [HR]: 2.55, 95% confidence interval [CI]: 1.22-5.33, P = .01), estimated glomerular filtration rate (HR: 0.979, 95% CI: 0.969-0.990, P < .001), HbA1c (HR: 0.825, 95% CI: 0.702-0.969, P = .01), and MPVLR (HR: 1.093, 95% CI: 1.020-1.172, P = .01). NLR showed a strong correlation with white blood cell count ( r = 0.60 [<0.001]) and c-reactive protein ( r = 0.63 [<0.001]), and a weak correlation with erythrocyte sedimentation rate ( r = 0.33 [<0.001]), though it was not associated with mortality. In conclusion, apart from other risk factors of mortality, we have for the first time demonstrated that the increasing value of MPVLR is a factor associated with one-year mortality in patients with DFIs.

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The Predictive Factors Associated With Comorbidities for Treatment Response in Outpatients With King Classification III Diabetes Foot Ulcers

Cited by 2 publications

References 18 publications

Outcome predictors for wound healing in patients with a diabetic foot ulcer

Outcome predictors for wound healing in patients with a diabetic foot ulcer

Mean Platelet Volume-to-Lymphocyte Ratio Is a Biomarker of 1-Year Mortality in Patients With Diabetic Foot Infections

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