Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity

Sharapova, Tatiana N.; Романова, Е. А.; Sashchenko, Lidia P.; Yashin, Denis V.

doi:10.1155/2018/4501273

Cited by 5 publications

(4 citation statements)

References 41 publications

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“…Granzyme B (GZMB), one of the effector molecules of CD4 + T cells, was also present in the peripheral blood, whereas CD4 + GZMA − IFN-γ + Th1 cells were rare in diseased tissue. CD4 + CTLs are widely distributed in humans ( 44 , 45 ) and mice ( 46 , 47 ). They recognize antigenic peptides and target cells through MHC class II (MHC-II)- and HLA-II-dependent antigen-specific pathways, respectively ( 45 ), and perform their killing functions by secreting GZMB and perforin.…”

Section: Adaptive Immunitymentioning

confidence: 99%

Immune Dysregulation in IgG4-Related Disease

et al. 2021

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Immunoglobin G4-related disease (IgG4-RD) is one of the newly discovered autoimmune diseases characterized by elevated serum IgG4 concentrations and multi-organ fibrosis. Despite considerable research and recent advances in the identification of underlying immunological processes, the etiology of this disease is still not clear. Adaptive immune cells, including different types of T and B cells, and cytokines secreted by these cells play a vital role in the pathogenesis of IgG4-RD. Antigen-presenting cells are stimulated by pathogens and, thus, contribute to the activation of naïve T cells and differentiation of different T cell subtypes, including helper T cells (Th1 and Th2), regulatory T cells, and T follicular helper cells. B cells are activated and transformed to plasma cells by T cell-secreted cytokines. Moreover, macrophages, and some important factors (TGF-β, etc.) promote target organ fibrosis. Understanding the role of these cells and cytokines implicated in the pathogenesis of IgG4-RD will aid in developing strategies for future disease treatment and drug development. Here, we review the most recent insights on IgG4-RD, focusing on immune dysregulation involved in the pathogenesis of this autoimmune condition.

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Section: Adaptive Immunitymentioning

confidence: 99%

Immune Dysregulation in IgG4-Related Disease

et al. 2021

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“…When we performed a similar analysis on tumors isolated from 18-week-old mice, we identified 5 upregulated genes and 30 downregulated genes in MP PA tumors (padj=0.05, log2FC=2) (Figure 4F, G) and no significant pathway enrichment was detected, most likely due to the reduced number of differentially expressed genes. Of note, the upregulation of Pglyrp1 , which has been shown to activate CD4+ T cells 44 , and the downregulation of Slc27a , Lama2 and Malat1 , which have been identified as poor prognosis markers in several breast cancer models 16,27, 33, 60 .…”

Section: Resultsmentioning

confidence: 99%

“…Finally, using differential gene expression analyses in early and late stage tumors from MP SED and MP PA mice, we have identified an increase in tumor-suppressor genes, such as Hoxb2 and Pglyrp1 4,44 , and a decrease in potential oncogenes, such as Slc27a1 and Malat1 16,33,60 in the tumors of MP PA mice. Interestingly, in our pilot study in NSG mice transplanted with tumor cells from a triple negative breast cancer patient, we observed a similar decrease in the expression of MALAT1 in the tumors isolated from NSG-PDX mice following 4 weeks of physical activity (Supp.…”

Section: Physical Activity Modulates Gene Expression In Hscsmentioning

confidence: 94%

Physical activity regulates the immune response to breast cancer by a hematopoietic stem cell-autonomous mechanism

Khair,

Hayes,

Tutto

et al. 2023

Preprint

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Physical activity is a modifiable lifestyle factor that is associated with a decreased risk for the development of breast cancer. While the exact mechanisms for the reduction in cancer risk due to physical activity are largely unknown, it is postulated that the biological reduction in cancer risk is driven by improvements in inflammation and immune function with exercise. Hematopoietic stem cells (HSCs) are the progenitor for all of the cells of the immune system and are involved in cancer immunosurveillance through differentiation into cytotoxic cell population. In this study, we investigate the role of physical activity (PA) in a spontaneously occurring model of breast cancer over time, with a focus on tumor incidence, circulating and tumor-infiltrating immune cells as well gene expression profiles of tumors and hematopoietic stem cells. Furthermore, we show that, in addition to a direct effect of PA on the immune cells of tumor-bearing mice, PA reduces the oxidative stress in HSCs of wildtype and tumor-bearing mice, and by doing so, alters the differentiation of the HSCs towards T cells in order to enhance cancer immunosurveillance.

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“…Genetic analyses have shown that genes coding for this protein constitute an evolutionarily highly conserved family present in both insect (Kurata 2014) and mammalian genomes (Dziarski 2004). Recent studies have shown that the Tag7 protein (PGLYRP1) can activate cells involved in anti-cancer activity (Sharapova et al 2018) and can serve as a potential marker in the diagnosis of rheumatoid arthritis (Luo et al 2019).…”

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confidence: 99%

Polymorphism of the PGLYRP1 gene, the value of selected performance and functional traits, and causes of culling in Holstein-Friesian red-white cows

Sablik,

Dybus,

Januś

et al. 2023

CZECH J ANIM SCI

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This research paper addresses the hypothesis that the peptidoglycan recognition protein 1 (PGLYRP1) gene polymorphism (Tyr76His; dbSNP ID: ss104796364) has an influence on some performance traits and causes of culling in Polish Holstein-Friesian red-white cows. The study involved 134 cows kept on a farm in the southwest of Poland. PGLYRP1 genotypes TT, CT, and CC were detected. It was shown that compared with cows with genotypes CT and TT, the individuals with genotype CC were characterised by higher lifetime yields and higher amounts of lactation milk, fat, and protein. A beneficial effect of genotype CC, compared with genotype TT, was also noted in the case of the lifespan and, consequently, the length of the productive life and the average number of lactations. Diseases of the musculoskeletal system (genotypes CC and TT) and disorders of the reproductive system (genotype CT) were the most common causes of culling. An essential practical observation was the potentially higher susceptibility of cows with genotype CC to mastitis, which resulted in the necessity to cull over one-fifth of the animals in this group. Simultaneously, no cows in this group were culled due to low performance or metabolic, gastrointestinal, and respiratory diseases. Therefore, the PGLYRP1 gene seems to be a promising potential herd health marker; however, to consider it the main gene, it is necessary to extend the investigations to include more individuals and other breeds of dairy cattle.

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Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity

Cited by 5 publications

References 41 publications

Immune Dysregulation in IgG4-Related Disease

Immune Dysregulation in IgG4-Related Disease

Physical activity regulates the immune response to breast cancer by a hematopoietic stem cell-autonomous mechanism

Polymorphism of the PGLYRP1 gene, the value of selected performance and functional traits, and causes of culling in Holstein-Friesian red-white cows

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