Extensively drug-resistant <em>Myroides odoratimimus</em> &ndash;&nbsp;a case series of urinary tract infections in immunocompromised patients

Abstract

PurposeWe report an outbreak of urinary tract infections (UTIs) caused by Myroides odoratimimus, which occurred in the largest clinical hospital in western Romania.Patients and methodsFrom June to August 2017, four strains of M. odoratimimus were isolated from the urine samples of patients hospitalized in the urology, diabetes, and surgery departments. Hospital records of all patients whose urine cultures were positive for M. odoratimimus were reviewed retrospectively. We also reviewed the cases reported in the literature.ResultsAll UTIs, except one, were hospital-acquired infections. All patients with M. odoratimimus UTIs were immunocompromised. Three patients underwent urinary catheterization with a Foley’s catheter upon admission in the emergency department and one presented for replacement of ureterostomy tubes. All Myroides isolates were resistant to almost all the tested antibiotics. Two patients were successfully treated with tigecycline and one was receiving antimicrobial treatment for another infection at the time of isolation of the microorganism.ConclusionAlthough M. odoratimimus is an uncommon pathogen, clinicians should be aware of its ability to cause UTI outbreaks, especially in the immunocompromised population. Due to its multi-drug resistance, it is important to rapidly identify Myroides spp. in order to choose the best treatment regimen.

Association ofMyroides odoratimimusin immunocompromized piglets with post weaning multisystemic wasting syndrome

“…Hospital‐acquired infections in immunocompromised humans caused by M . odoratimimus range from erysipelas and soft tissue infections to septicaemia leading to septic shock (Benedetti et al ; Ktari et al ; Maraki et al ; Beharrysingh, ; Willems et al ; Licker et al ). The association of M .…”

“…Hospital-acquired infections in immunocompromised humans caused by M. odoratimimus range from erysipelas and soft tissue infections to septicaemia leading to septic shock (Benedetti et al 2011;Ktari et al 2012;Maraki et al 2012;Beharrysingh, 2017;Willems et al 2017;Licker et al 2018). The association of M. odoratimimus in post pig bite wound infections in immunocompromised individuals has been reported (Goldstein et al 1990;Maraki et al 2012).…”

“…). Despite the low pathogenicity potential, management of Myroides infection is difficult owing to high resistant towards most of the available antibiotics (Licker et al ). Pathogenicity of other species of the genus Myroides namely, M .…”

“…The genus comprises of two pathogenic species, Myroides odoratus and Myroides odoratimimus (Maraki et al 2012). These species are considered as lowgrade opportunistic pathogens that cause life-threatening infections occasionally and are rarely isolated from clinical samples (Licker et al 2018). Despite the low pathogenicity potential, management of Myroides infection is difficult owing to high resistant towards most of the available antibiotics (Licker et al 2018).…”

“…These species are considered as lowgrade opportunistic pathogens that cause life-threatening infections occasionally and are rarely isolated from clinical samples (Licker et al 2018). Despite the low pathogenicity potential, management of Myroides infection is difficult owing to high resistant towards most of the available antibiotics (Licker et al 2018). Pathogenicity of other species of the genus Myroides namely, M. pelagicus, M. profundi, M. marinus, M. phaeus, M. guanonis, M. xuanwuensis, M. injenensis and M. indicus for humans is uncertain (Yoon et al 2006;Zhang et al 2008;Cho et al 2011;Yan et al 2012;Tomova et al 2013;Zhang et al 2014;Paek et al 2015;Ram et al 2015).…”