Characterization of respiratory infection viruses in hospitalized children from Naples province in Southern Italy

Botti, Chiara; Micillo, Alberto; Ricci, Giuseppe; Russo, Adolfo; Denisco, Alberto; Cantile, Monica; Scognamiglio, Giosuè; Rosa, A. De; Botti, Gerardo

doi:10.3892/etm.2018.6061

Cited by 10 publications

(19 citation statements)

References 37 publications

(34 reference statements)

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“…Calvo [ 17 ] reported a prevalence of ADV infection in November and December, though according to Kim [ 14 ], ADV did not show significant seasonality. Botti [ 18 ] indicated that ADV is mainly prevalent in summer.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics of four common respiratory viral infections in children

Zhu

Zhang

et al. 2021

Virol J

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Background Viruses are the main infectious agents of acute respiratory infections in children. We aim to describe the epidemiological characteristics of viral pathogens of acute respiratory tract infections in outpatient children. Methods From April 2018 to March 2019, the results of viral detection using oral pharyngeal swabs from 103,210 children with acute respiratory tract infection in the outpatient department of the Children’s Hospital, Zhejiang University School of Medicine, were retrospectively analyzed. Viral antigens, including adenovirus (ADV), influenza A (FLUA), influenza B (FLUB) and respiratory syncytial virus (RSV), were detected by the colloidal gold method. Results At least one virus was detected in 38,355 cases; the positivity rate was 37.2%. A total of 1910 cases of mixed infection with two or more viruses were detected, and the positivity rate of multiple infection was 1.9%. The ADV positivity rate was highest in the 3–6-year-old group (18.7%), the FLUA positivity rate was highest in the > 6-year-old group (21.6%), the FLUB positivity rate was highest in the > 6-year-old group (6.6%), and the RSV positivity rate was highest in the < 1-year-old group (10.6%). There was a significant difference in the positivity rate of viral infection among different age groups (χ2 = 1280.7, P < 0.001). The rate of positive viral infection was highest in winter (47.1%). The ADV infection rate was highest in spring (18.2%). The rates of FLUA and FLUB positivity were highest in winter (28.8% and 3.6%, respectively). The rate of RSV positivity was highest in autumn (17.4%). The rate of positive viral infection in different seasons was significantly different (χ2 = 6459.1, P < 0.001). Conclusions Viral infection rates in children differ for different ages and seasons. The positivity rate of ADV is highest in the preschool period and that of RSV is highest in infants; that of FLU increases with age. The total positive rate of viral infection in different seasons is highest in winter, as is the rate of FLU positivity.

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Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics of four common respiratory viral infections in children

Zhu

Zhang

et al. 2021

Virol J

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“…al reported a high prevalence of rhinovirus, followed by RSV, parainfluenza virus, and less commonly influenza virus, metapneumovirus and coronavirus [ 37 ]. Another retrospective study published recently from Italy also identified rhinovirus as the most common virus, followed by adenovirus, RSV and parainfluenza whereas influenza virus and metapneumovirus were less common [ 38 ]. The differences in distribution may be attributed to the different viral detection kits that were used: the PneumoVir multiplex PCR, the FilmArray Respiratory Panel, and PureLink Viral RNA/DNA mini Kit respectively in the studies and to differences in inclusion criteria, seasonal variation, and population.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology and clinical characteristics of viral infections in hospitalized children and adolescents with cancer in Lebanon

et al. 2020

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Background Viral infections in children and adolescents with malignancy are commonly encountered and have a significant impact on morbidity and mortality. Studies and epidemiological data regarding viral infections in children with cancer in developing countries are lacking. This retrospective cohort study aims to assess the burden of viral infections in children and adolescents with cancer, by assessing prevalence, risk factors, as well as morbidity and mortality of common viruses over a period of 8 years. Methods and findings Medical records of cancer patients treated at the Children Cancer Center of Lebanon were reviewed and 155 participants under the age of 21 were identified with at least one documented viral infection during the period from July 2009 to November 2017. This subset included 136 participants with active malignancy and 19 participants with a history of cancer who underwent hematopoietic stem cell transplantation [HSCT] and were in remission; the latter group was analyzed separately. Information regarding participant characteristics, hospital course, and complications were obtained. Associations between viral infections and certain factors were assessed. In the cohort, 64% were male, 81% were Lebanese. In participants with active malignancy, 90% received chemotherapy in the 6 months preceding the viral infection episode, 11% received radiotherapy. 51% of participants were neutropenic at the time of viral detection, and 77% were lymphopenic. 17% experienced a bacterial coinfection, and 3 experienced a viral co-infection. Among 162 viral infection episodes,

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“…Calvo [17] reported a prevalence of ADV infection in November and December, though according to Kim [14] , ADV did not show signi cant seasonality. Botti [18] indicated that ADV is mainly prevalent in summer.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological characteristics of four common respiratory viral infections in children

Zhu

Zhang

et al. 2020

Preprint

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Background: Viruses are the main infectious agents of acute respiratory infections (ARIs) in children. We aim to describe the epidemiological characteristics of viral pathogens of acute respiratory tract infections in outpatient children.Methods: From April 2018 to March 2019, the results of viral detection using oral pharyngeal swabs from 103,210 children with acute respiratory tract infection in the outpatient department of the Children’s Hospital, Zhejiang University School of Medicine, were retrospectively analyzed. Viral antigens, including adenovirus (ADV), influenza A (FLUA), influenza B (FLUB) and respiratory syncytial virus (RSV), were detected by the colloidal gold method.Results: At least one virus was detected in 38,355 cases; the positivity rate was 37.2%. A total of 1910 cases of mixed infection with two or more viruses were detected, and the positivity rate of multiple infection was 1.9%. The ADV positivity rate was highest in the 3-6-year-old group (18.7%), the FLUA positivity rate was highest in the >6-year-old group (21.6%), the FLUB positivity rate was highest in the >6-year-old group (6.6%), and the RSV positivity rate was highest in the <1-year-old group (10.6%). There was a significant difference in the positivity rate of viral infection among different age groups (χ2 = 1280.7, P < 0.001). The rate of positive viral infection was highest in winter (47.1%). The ADV infection rate was highest in spring (18.2%). The rates of FLUA and FLUB positivity were highest in winter (28.8% and 3.6%, respectively). The rate of RSV positivity was highest in autumn (17.4%). The rate of positive viral infection in different seasons was significantly different (χ2 = 6459.1, P < 0.001).Conclusions: Viral infection rates in children differ for different ages and seasons. The positivity rate of ADV is highest in the preschool period and that of RSV is highest in infants; that of FLU increases with age. The total positive rate of viral infection in different seasons is highest in winter, as is the rate of FLU positivity.

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Characterization of respiratory infection viruses in hospitalized children from Naples province in Southern Italy

Cited by 10 publications

References 37 publications

Epidemiological characteristics of four common respiratory viral infections in children

Epidemiological characteristics of four common respiratory viral infections in children

Epidemiology and clinical characteristics of viral infections in hospitalized children and adolescents with cancer in Lebanon

Epidemiological characteristics of four common respiratory viral infections in children

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