Occurrence, distribution and ecological risks of organophosphate esters and synthetic musks in sediments from the Hun River

Zeng, Xiangying; Hu, Qiongpu; He, Liang-Ying; Liu, Zhiyang; Gao, Shutao; Yu, Zhiqiang

doi:10.1016/j.ecoenv.2018.05.034

Cited by 34 publications

(4 citation statements)

References 40 publications

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“…Concentrations of tri-OPEs in the present study were higher than those in river sediments from Beijiang River (48−470; median 110 ng g −1 ), 11 Xijiang River (8.3−48; median 32 ng g −1 ), 11 and the Guangzhou section of Pearl River (62−220; median 130 ng g −1 ) 11 within the Pearl River Delta, South China. Levels of tri-OPEs were also higher than those in sediments from Hun River (a tributary of the Liao River system) (3.5−46 ng g −1 ) 46 and Liao River (20−230 ng g −1 ) 47 of Northeast China. Levels of tri-OPEs in the present study were also much higher than those in oceanic sediment from the Bohai Sea and the Yellow Sea (0.08−4.6 ng g −1 ) 48 and from the North Pacific to the Arctic Ocean (0.16−4.7 ng g −1 ).…”

Section: Resultsmentioning

confidence: 86%

Organophosphate Diesters in Urban River Sediment from South China: Call for More Research on Their Occurrence and Fate in Field Environment

et al. 2021

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Despite numerous studies on the distributions of organophosphate triesters (tri-OPEs) in various environmental compartments, few have investigated organophosphate diesters (di-OPEs) in natural environments. This study was conducted to examine the co-occurrence of tri-and di-OPEs in urban river sediment. The concentrations (range (median); dry weight) of ∑tri-OPE and ∑di-OPE were 17−4400 (330) and 9.0−1200 (130) ng g −1 , respectively. The concentrations of diphenyl phosphate (DPHP), bis-(1-chloro-2-propyl) phosphate (BCIPP), bis(2-ethylhexyl) phosphate (BEHP), dibutyl phosphate (DBP), and bis-(butoxyethyl) phosphate (BBOEP) were 1.7−520 (45), 3.2−590 (51), 1.7−100 ( 22), 0.43−9.6 (1.2), and 0.41−4.4 (0.74) ng g −1 , respectively. Positive correlations between the levels of di-OPE and tri-OPE compounds (p < 0.05) together with high concentration ratios of DPHP to TPHP (2.0−96; median 17) and BCIPP to TCIPP (1.6−160; median 5.7) suggested that DPHP and BCIPP were mainly from degradation of TPHP and TCIPP. More studies are needed to illustrate the environmental occurrence, behavior, fate, and ecological risk of di-OPEs.

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Section: Resultsmentioning

confidence: 86%

Organophosphate Diesters in Urban River Sediment from South China: Call for More Research on Their Occurrence and Fate in Field Environment

et al. 2021

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“…As a consequence, OPFRs are ubiquitously found in numerous environment matrices (atmosphere, soil, surface water, sediments, etc. ), organisms, drinking water, agricultural products, and foodstuffs. − Inhalation and dermal contact of air and dust in an indoor environment are regarded as the major pathways of OPFRs exposure for humans, because building materials and indoor products (furniture, electronics, carpets, curtains, etc.) are considered to be a significant source of OPFRs .…”

Section: Introductionmentioning

confidence: 99%

Prenatal Exposure to Organophosphate Flame Retardants and the Risk of Low Birth Weight: A Nested Case-Control Study in China

Luo

Liu

Tao

et al. 2020

Environ. Sci. Technol.

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Organophosphate flame retardants (OPFRs), used as flame retardants and plasticizers, have been suggested to impair fetal growth and development in toxicological studies, but epidemiological data are extremely limited. This study was designed to explore whether prenatal exposure to OPFRs was associated with an increased risk of low birth weight (LBW) using a nested case-control design based on the ongoing prospective birth cohort in Wuhan, China. A total of 113 cases and 226 matched controls recruited from this cohort project in 2014−2016 were included. OPFR metabolite concentrations in maternal urine samples collected in the third trimester were determined, and birth outcomes were extracted from medical records. Compared with the lowest tertile of diphenyl phosphate (DPHP) concentrations, pregnant women with the highest tertile of DPHP had a 4.62-fold (95% confidence interval (CI): 1.72, 12.40) significantly increased risk for giving birth to LBW infants, with a significant dose−response relationship (p-trend < 0.01). After stratification by newborn sex, the significant positive association of DPHP levels with LBW risk was merely observed among female newborns. Our results suggest a positive association between maternal urinary DPHP concentrations and LBW risk for the first time, and the effect appears be sex-specific.

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“…The global use index of OPEs was 465,000 tons in 2006 (van der Veen & de Boer, 2012), which raised to 680,000 tons in 2015, with an increased usage rate of 7.9% annually (Zeng, Wu, et al, 2018). Reports suggested the presence of OPEs in water (Reemtsma et al, 2008), sediments (Zeng, Hu, et al, 2018), drinking water (Ding et al, 2015), indoor dust (Hoffman et al, 2015), and wastewater treatment plant (WWTP) effluent (Marklund et al, 2005; Sundkvist et al, 2010). The reason behind the presence of OPEs in the air, drinking water, and foods is that they are not covalently bound to indoor and outdoor products (Hou et al, 2021; Wang et al, 2017; Wei et al, 2015), which tend to get released in the surrounding micro-environments due to volatilization, abrasion, and leaching (Hou et al, 2021; Wei et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Tri-n-butyl phosphate inhibits neurogenesis and motor functions during embryonic development in zebrafish

Chakraborty,

Ahire,

Joshi

et al. 2023

Preprint

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Tri-n-butyl phosphate (TBP), an organophosphate ester (OPE), is heavily used as a solvent in synthetic resins, inks, and adhesives and as an antifoaming agent in detergents and emulsion products. Further, it is used as a flame retardant and plasticizer in the fabric and electronics industry. Further, TBP is used to extract uranium, plutonium, and thorium. Thus, widespread uses of TBP in industrialized countries led to the release of TBP and its metabolites, dibutyl phosphate (DBP) and monobutyl phosphate (MBP), in the environment, including air, soil, and water, and get detected in human samples. Accumulating these OPEs over time in humans and other animals may develop toxicological effects. The reports also say OPEs contaminants pass through the mother-fetal transmission route and may affect embryonic development. However, the impact of TBP and its metabolites on vertebrate development has been poorly studied. Ex-Utero development, short generation time, high fecundity, optical transparency, and genetic and physiological similarity to humans make the zebrafish a preferred model for studying vertebrate development, organogenesis, small molecule screening, toxicological evaluation, etc. Thus, we aim to explore the toxic effects of TBP, DBP, and MBP on vertebrate organogenesis and overall embryonic development using zebrafish as a model organism. Our study found that TBP inhibits neural growth resulting in decreased spontaneous movements frequency at 22 and 28 hpf without altering the somite and overall embryonic growth in lower doses. In contrast, in lower concentrations, DBP-treated embryos showed normal neuronal and embryonic development and increased spontaneous movement frequency at 22 and 28 hpf. Further, we found that in higher concentrations, TBP is teratogenic, DBP is lethal to the embryos, and MBP did not show detectable toxic effects in the developing embryos. Altogether, we found that TBP inhibits neurogenesis, and its metabolite DBP is neuroexcitatory during embryonic development.

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Occurrence, distribution and ecological risks of organophosphate esters and synthetic musks in sediments from the Hun River

Cited by 34 publications

References 40 publications

Organophosphate Diesters in Urban River Sediment from South China: Call for More Research on Their Occurrence and Fate in Field Environment

Organophosphate Diesters in Urban River Sediment from South China: Call for More Research on Their Occurrence and Fate in Field Environment

Prenatal Exposure to Organophosphate Flame Retardants and the Risk of Low Birth Weight: A Nested Case-Control Study in China

Tri-n-butyl phosphate inhibits neurogenesis and motor functions during embryonic development in zebrafish

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