Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats

Bhattacharya, Sanchari; Mondal, Laboni; Mukherjee, Biswajit; Dutta, Lopamudra; Ehsan, Iman; Debnath, Mita Chatterjee; Gaonkar, Raghuvir H.; Pal, Mahesh; Majumdar, Subrata

doi:10.1016/j.nano.2018.05.011

Cited by 79 publications

(54 citation statements)

References 40 publications

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“…In vitro mechanistic investigations showed that APG suppressed the snail/slug signaling and downregulated DPPIV enzyme to modulate the EMT and the invasive ability of both EGFR positive and negative NSCLC cells (Chang et al, 2018). Some of preclinical studies showed that the efficacy of APG enhanced when combined with other chemotherapeutic agents (Hu et al, 2018) or loaded in nanocarriers (Bhattacharya et al, 2018).…”

Section: Phytochemicals In Pre-clinical Trialsmentioning

confidence: 99%

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

et al. 2020

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Cancer is a severe health problem that continues to be a leading cause of death worldwide. Increasing knowledge of the molecular mechanisms underlying cancer progression has led to the development of a vast number of anticancer drugs. However, the use of chemically synthesized drugs has not significantly improved the overall survival rate over the past few decades. As a result, new strategies and novel chemoprevention agents are needed to complement current cancer therapies to improve efficiency. Naturally occurring compounds from plants known as phytochemicals, serve as vital resources for novel drugs and are also sources for cancer therapy. Some typical examples include taxol analogs, vinca alkaloids such as vincristine, vinblastine, and podophyllotoxin analogs. These phytochemicals often act via regulating molecular pathways which are implicated in growth and progression of cancer. The specific mechanisms include increasing antioxidant status, carcinogen inactivation, inhibiting proliferation, induction of cell cycle arrest and apoptosis; and regulation of the immune system. The primary objective of this review is to describe what we know to date of the active compounds in the natural products, along with their pharmacologic action and molecular or specific targets. Recent trends and gaps in phytochemical based anticancer drug discovery are also explored. The authors wish to expand the phytochemical research area not only for their scientific soundness but also for their potential druggability. Hence, the emphasis is given to information about anticancer phytochemicals which are evaluated at preclinical and clinical level.

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Section: Phytochemicals In Pre-clinical Trialsmentioning

confidence: 99%

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

et al. 2020

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“…It is worth emphasizing that these nanoparticles were effective in maintaining photodegradation through ultraviolet light [ 74 ]. Other study on apigenin encapsulated in PLGA nanoparticles showed that intravenous administration of this molecules successfully reached HepG2 and Huh-7 cells in vitro as well as the liver of carcinogenic animals and delayed development of hepatocellular carcinoma in rats [ 75 ]. Novel nanomaterials have recently been investigated, which contribute to enhanced solubility and bioavailability of apigenin via preparation of solid dispersions of mesoporous silica nanoparticles [ 76 ].…”

Section: Apigeninmentioning

confidence: 99%

Flavonoid Nanoparticles: A Promising Approach for Cancer Therapy

2020

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Flavonoids, a ubiquitous group of naturally occurring polyphenolic compounds, have recently gained importance as anticancer agents. Unfortunately, due to low solubility, absorption, and rapid metabolism of dietary flavonoids, their anticancer potential is not sufficient. Nanocarriers can improve the bioavailability of flavonoids. In this review we aimed to evaluate studies on the anticancer activity of flavonoid nanoparticles. A review of English language articles published until 30 June 2020 was conducted, using PubMed (including MEDLINE), CINAHL Plus, Cochrane, and Web of Science data. Most studies determining the anticancer properties of flavonoid nanoparticles are preclinical. The potential anticancer activity focuses mainly on MCF-7 breast cancer cells, A549 lung cancer cells, HepG2 liver cancer cells, and melanoma cells. The flavonoid nanoparticles can also support the anti-tumour effect of drugs used in cancer therapy by enhancing the anti-tumour effect or reducing the systemic toxicity of drugs.

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“…The Consulting the literature showed that the phenolic acid components chlorogenic acid (Xue et al, 2017;Shao, Zhang, Chen, & Sun, 2015) and caffeic acid (Brautigan, Gielata, Heo, Kubicka, & Wilkins, 2018), and the flavonoids scutellarin (Nie et al, 2018;Sun et al, 2018;Tang & Gao, 2019), isoorientin (Huang, Jin et al, 2018;Lin et al, 2016), isovitexin (Lv, 2018), scutellarein (Jiang et al, 2018;Lu, Li, Li, & Asia, 2017;Zheng et al, 2017), luteolin (Niu, Guo, Gan, Bao, & Ren, 2015) and apigenin (Bhattacharya et al, 2018;Masuelli et al, 2017;Cai et al, 2011) had different degrees of inhibition on tumor cells. Among them, caffeic acid, isoorientin, isovitexin, luteolin and apigenin had better antiliver tumor activities.…”

Section: Analysis Of Migration Components In Plasmamentioning

confidence: 99%

Analysis of plasma migration components in Patrinia villosa (Thunb.) Juss. effective parts by UPLC–Q‐TOF–MS

Han

Wang

Yang

et al. 2019

Biomedical Chromatography

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Patrinia villosa (Thunb.) Juss. (PVJ) is described as pungent, bitter and slightly cold in Chinese medicine, and is associated with the large intestine, stomach and liver meridians. The preliminary experiments of our research team proved that PVJ total flavonoids have excellent inhibitory effects on liver cancer cells. The present experiment uses the UPLC–Q‐TOF–MS technology and serum pharmacochemistry methods to analyze the chemical components in vitro and in vivo of PVJ antiliver tumors. A total of 14 chemical components were identified in the total flavonoids extract of PVJ, and it is mainly composed of flavonoids, flavonones, flavonols and phenolic acids. At the same time, seven prototypical components and seven metabolic components were detected in the drug‐containing plasma. Hydrocaffeate and scutellarein are the phase I metabolites of caffeic acid and scutellarin, respectively. Sulfated apigenin, sulfated luteolin, sulfated kaempferol and methylated kaempferol are the II phase metabolites of apigenin, luteolin, kaempferol, respectively. The experiment provides a reference for the research and development of antitumor drug candidates, and provides a basis for revealing the bioactive components of PVJ and the antitumor mechanism.

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Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats

Cited by 79 publications

References 40 publications

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

Flavonoid Nanoparticles: A Promising Approach for Cancer Therapy

Analysis of plasma migration components in Patrinia villosa (Thunb.) Juss. effective parts by UPLC–Q‐TOF–MS

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