An ingestible bacterial-electronic system to monitor gastrointestinal health

Mimee, Mark; Nadeau, Phillip; Hayward, Alison; Carim, Sean; Flanagan, Sarah E.; Jerger, Logan Andrew; Collins, Joy; McDonnell, Shane; Swartwout, Richard; Citorik, Robert J.; Bulović, Vladimir; Langer, Robert; Traverso, Giovanni; Chandrakasan, Anantha P.; Lu, Timothy K.

doi:10.1126/science.aas9315

Cited by 416 publications

(366 citation statements)

References 36 publications

(39 reference statements)

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“…Finally, we need to move the needle from empirically selected prebiotic and probiotic therapies to the next generation of precise mechanism-based diagnostic and therapeutic interventions. The use of genetically engineered bacterial strains to assess the gut environment, release metabolites of interest at specific locations within the GI tract, and optimize drug metabolism appears to be on the horizon 190, 191 . Rapid advances in these areas provide an optimistic outlook for microbiotabased interventions in FGIDs.…”

Section: Functional Gi Disordersmentioning

confidence: 99%

The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders

Shin

Preidis

Shulman

et al. 2019

Clinical Gastroenterology and Hepatology

127

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The importance of gut microbiota in gastrointestinal (GI) physiology was well described, but our ability to study gut microbial ecosystems in their entirety was limited by culture-based methods prior to the sequencing revolution. The advent of high-throughput sequencing opened new avenues, allowing us to study gut microbial communities as an aggregate, independent of our ability to culture individual microbes. Early studies focused on association of changes in gut microbiota with different disease states, which was necessary to identify a potential role for microbes and generate novel hypotheses. Over the past few years the field has moved beyond associations to better understand the mechanistic implications of the microbiome in the pathophysiology of complex diseases. This movement also has resulted in a shift in our focus toward therapeutic strategies, which rely on better understanding the mediators of gut microbiota-host cross-talk. It is not surprising the gut microbiome has been implicated in the pathogenesis of functional gastrointestinal disorders given its role in modulating physiological processes such as immune development, GI motility and secretion, epithelial barrier integrity, and brain-gut communication. In this review, we focus on the current state of knowledge and future directions in microbiome research as it pertains to functional gastrointestinal disorders. We summarize the factors that help shape the gut microbiome in human beings. We discuss data from animal models and human studies to highlight existing paradigms regarding the mechanisms underlying microbiota-mediated alterations in physiological processes and their relevance in human interventions. While translation of microbiome science is still in its infancy, the outlook is optimistic and we are advancing in the right direction toward precise mechanism-based microbiota therapies.

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Section: Functional Gi Disordersmentioning

confidence: 99%

The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders

Shin

Preidis

Shulman

et al. 2019

Clinical Gastroenterology and Hepatology

127

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“…On a more expansive scale, the Pediatric Research using Integrated Sensor Monitoring Systems (PRISMS) is developing both wearable and nonwearable sensors to monitor the internal and external exposome in children in their natural environment. Other groups are developing ingestible biosensors (a device that can measure chemical substances) . A thorough review of sensors has been reported elsewhere …”

Section: Future Directionsmentioning

confidence: 99%

“…Other groups are developing ingestible biosensors (a device that can measure chemical substances). (34) A thorough review of sensors has been reported elsewhere. (35)…”

Section: Future Directionsmentioning

confidence: 99%

Studying the Exposome to Understand the Environmental Determinants of Complex Liver Diseases

Cheung¹,

Walker²,

Juran³

et al. 2019

Hepatology

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“…[56] Aprobiotic strain of E. coli was modified to contain the following genes:asynthetic promoter that is regulated by HrtR, ah eme-responsive transcriptional repressor;C huA an outer-membrane heme transporter;a nd luxCDABE an operon that encodes all the enzymes and substrates required for photoluminescence. [56] Aprobiotic strain of E. coli was modified to contain the following genes:asynthetic promoter that is regulated by HrtR, ah eme-responsive transcriptional repressor;C huA an outer-membrane heme transporter;a nd luxCDABE an operon that encodes all the enzymes and substrates required for photoluminescence.…”

Section: Ingestible Sensors That Use Synthetic Biologymentioning

confidence: 99%

Advances in Materials and Structures for Ingestible Electromechanical Medical Devices

Bettinger

2018

Angew Chem Int Ed

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Ingestible biomedical devices that diagnose, prevent, or treat diseases has been a dream of engineers and clinicians for decades. The increasing apparent importance of gut health on overall well-being and the prevalence of many gastrointestinal diseases have renewed focus on this emerging class of medical devices. Several prominent examples of commercially successful ingestible medical devices exist. However, many technical challenges remain before ingestible medical devices can achieve their full clinical potential. This Minireview summarizes recent discoveries in this interdisciplinary topic including novel materials, advanced materials processing techniques, and select examples of integrated ingestible electromechanical systems. After a brief historical perspective, these topics will be reviewed with a dedicated focus on advanced functional materials and fabrication strategies in the context of clinical translation and potential regulatory considerations. Future perspectives, challenges, and opportunities related to ingestible medical devices will also be summarized.

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An ingestible bacterial-electronic system to monitor gastrointestinal health

Cited by 416 publications

References 36 publications

The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders

The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders

Studying the Exposome to Understand the Environmental Determinants of Complex Liver Diseases

Advances in Materials and Structures for Ingestible Electromechanical Medical Devices

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