Phenotypes of COPD in an Austrian population

Abstract

There were significant differences in COPD outcome measures between predefined phenotypes of COPD in this study. The majority of patients with stable COPD in this Austrian population were not treated according to current COPD guidelines. While non-exacerbators appear to have been overtreated, patients with an asthma-COPD overlap appear to have been undertreated.

The characteristics of the frequent exacerbator with chronic bronchitis phenotype and non-exacerbator phenotype in patients with chronic obstructive pulmonary disease: a meta-analysis and system review

“…The main reason may be that CAT also includes many aspects of quality of life, while mMRC only reflects the degree of dyspnea and does not take cognizance of other important symptoms of COPD, such as cough, sputum, chest tightness, and depression [27] . In another study, compared with other phenotypes, patients with the FE-CB phenotype had higher CAT score and lower motor ability, while patients with the NE phenotype had higher lung function index, fewer symptoms, and lower CAT score [7] . The conclusion is similar to that of the present study.…”

“…In terms of clinical characteristics, there is conflicting evidence of the association of these phenotypes with pulmonary function, the quantity of cigarettes smoked(pack-years), COPD Assessment Test (CAT) score, body mass index (BMI), frequency of acute exacerbations, St. George's questionnaire score (SGRQ), and complications. In a study, patients with FE-CB phenotype showed worse pulmonary function, higher CAT score, worse endurance to physical labor [6] , and higher incidence of heart failure, anxiety, depression, and other complications [7] . Among all phenotypes, FE-CB was associated with more than three complications [8] .…”

The characteristics of the frequent exacerbator with chronic bronchitis phenotype and non-exacerbator phenotype in patients with chronic obstructive pulmonary disease: a meta-analysis and system review

“…The main reason may be that CAT also includes many aspects of quality of life, while mMRC only reflects the degree of dyspnea and does not take cognizance of other important symptoms of COPD, such as cough, sputum, chest tightness, and depression [26] . In another study, compared with other phenotypes, patients with the FE-CB phenotype had higher CAT score and lower motor ability, while patients with the NE phenotype had higher lung function index, fewer symptoms, and lower CAT score [6] . The conclusion is similar to that of the present study.…”

“…In terms of clinical characteristics, there is conflicting evidence of the association of these phenotypes with pulmonary function, the quantity of cigarettes smoked(pack-years), COPD Assessment Test (CAT) score, body mass index (BMI), frequency of acute exacerbations, St. George's questionnaire score (SGRQ), and complications. In a study, patients with FE-CB phenotype showed worse pulmonary function, higher CAT score, worse endurance to physical labor [5] , and higher incidence of heart failure, anxiety, depression, and other complications [6] . Among all phenotypes, FE-CB was associated with more than three complications [7] .…”

The characteristics of the frequent exacerbator with chronic bronchitis phenotype and non-exacerbator phenotype in patients with chronic obstructive pulmonary disease: a meta-analysis and system review

“…In terms of clinical characteristics, there is conflicting evidence of the association of these phenotypes with smoking, pulmonary function, COPD Assessment Test (CAT) score, frequency of acute exacerbations, body mass index (BMI), St. George's questionnaire score (SGRQ), and complications. In a study, patients with FE-CB phenotype showed worse pulmonary function, higher CAT score, worse endurance to physical labor [6], and higher incidence of heart failure, anxiety, depression, and other complications [7]. Among all phenotypes, FE-CB was associated with more than three complications [8].…”