Premenopausal women with recurrent urinary tract infections have lower quality of life

Ennis, Siobhan; Guo, Huifang; Raman, Lata; Tambyah, Paul A.; Chen, Swaine L.; Tiong, Ho Yee

doi:10.1111/iju.13698

Cited by 29 publications

(29 citation statements)

References 27 publications

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“…The study also showed that women with recurrent urinary infections have a compromise in physical and psychological aspects related to the quality of life, signi cantly higher than women in the control group. These results corroborate studies carried out with Asian and European women, with recurrent urinary tract infections, showing a wide negative impact of recurrent infections on the quality of life of women, mainly affecting the physical and mental dimensions [1,13].…”

Section: Discussionsupporting

confidence: 89%

“…Despite a recent multi-center European study pointing out that prophylactic treatment can reduce the number of infectious episodes and improve the quality of life of women, the lack of consensus on prophylaxis and treatment of recurrent urinary infections in Latin America hinders the adoption of prophylactic measures [1,2,13]. Thus, further studies are needed to assess the effectiveness, risks, and bene ts of different prophylactic options in the health and quality of life of women with recurrent urinary infections.…”

Section: Discussionmentioning

confidence: 99%

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Impact of Recurrent Urinary Infections on the Quality of Life of Women in Outpatient Care: a Case-control Study

Lourenção¹,

Oliveira²,

Eduardo³

et al. 2021

Preprint

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Background: The repetitive urinary tract infections impact women's quality of life and represent an important problem for women's physical and mental health, causing relevant social impacts. This study aimed to evaluate the impact of recurrent urinary tract infections on the quality of life of women with recurrent infections.Methods: This is a case-control study with 49 women with recurrent urinary tract infections, confirmed by urine culture, without complications and 49 women without recurrent urinary tract infections, seen at an outpatient clinic of a public teaching hospital in the city of Niterói, Rio de Janeiro, Brazil. Quality of life was evaluated using the Brazilian version of the World Health Organization's shortened questionnaire, the WHOQOL-Bref.Results: Women with urinary tract infections showed greater impairment of quality of life in the physical (p = 0.007) and psychological (p = 0.038) domains, with lower quality of life score in their self-assessment (p = 0.002), when compared to the group control. Women with recurrent urinary infection had mean scores significantly lower than the control group in the Energy and fatigue (p = 0.003), Positive feelings (p = 0.014), Self-esteem (p = 0.040), Dependence on medication (p = 0.029), Negative feelings (p = 0.023) and Recreation and leisure (p = 0, 0.041).Conclusions: Recurrent urinary tract infections have an important impact on the quality of life of women, especially in the Physical and Psychological domains, representing a significant problem for women, health professionals, and the health system.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Impact of Recurrent Urinary Infections on the Quality of Life of Women in Outpatient Care: a Case-control Study

Lourenção¹,

Oliveira²,

Eduardo³

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…Lower urinary tract symptoms (LUTS) are among the most common urologic conditions in the older population . As the incidence of LUTS and frailty increases with age, the concept of frailty has been recognized as a key factor in older individuals with LUTS . However, only a few studies have evaluated the influence of frailty on LUTS .…”

Section: Introductionmentioning

confidence: 99%

Relationship between frailty and lower urinary tract symptoms among community‐dwelling adults

Sato

Imai

Matsumoto

et al. 2019

LUTS

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Objectives: To evaluate the relationship between frailty and lower urinary tract symptoms (LUTS), the association of frailty and LUTS remains unclear. Methods: This cross-sectional study investigated LUTS and frailty in 710 individuals (249 men and 461 women, aged ≥60 years) who participated in the Iwaki Health Promotion Project between 2014 and 2015 in Hirosaki, Japan. Parameters of frailty were compared for individuals with mild and moderate to severe symptoms of LUTS. The International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS) were used to evaluate LUTS. Frailty was evaluated by the frailty phenotype (FP), modified frailty index (mFI), and frailty discriminant score (FDS). The influence of frailty on LUTS was investigated by multivariate logistic regression analyses.Results: Frailty parameters of age, renal function, and lower physical activity were significantly associated with severity of IPSS and OABSS. FP and mFI were significantly associated with severity of OABSS and IPSS, respectively. The FDS was significantly associated with severity of IPSS and OABSS. FP, mFI, and FDS were significantly associated with severity of nocturia. Multivariate logistic regression analyses revealed that FDS was independently associated with the severity of IPSS, OABSS, and nocturia, whereas FP and mFI were significantly associated with the severity of nocturia alone.Conclusions: Individuals with LUTS are potentially frailer than those without LUTS.Although the influence of frailty on LUTS is different depending on the measurement tool, attention for frailty is necessary for subjects with LUTS.

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“…Urinary tract infections (UTIs) and their recurrence are associated with substantial health care burdens and morbidity globally, including impacts on the daily activities and quality of life of sufferers ( 1 , 2 ). UTIs are defined as either uncomplicated (uUTIs) or complicated (cUTIs).…”

Section: Introductionmentioning

confidence: 99%

Dose Selection for Phase III Clinical Evaluation of Gepotidacin (GSK2140944) in the Treatment of Uncomplicated Urinary Tract Infections

Scangarella-Oman

Hossain

Hoover

et al. 2022

Antimicrob Agents Chemother

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Antibiotics are the current standard of care treatment for uncomplicated urinary tract infections (uUTIs). However, increasing rates of bacterial antibiotic resistance necessitate novel therapeutic options. Gepotidacin is a first-in-class triazaacenaphthylene antibiotic that selectively inhibits bacterial DNA replication by interaction with the bacterial subunits of DNA gyrase (GyrA) and topoisomerase IV (ParC). Gepotidacin is currently in clinical development for the treatment of uUTIs and other infections. In this article, we review data for gepotidacin from nonclinical studies including: in-vitro activity, in-vivo animal efficacy, and pharmacokinetic (PK) and pharmacokinetic/pharmacodynamic (PK/PD) models that informed dose selection for phase III clinical evaluation of gepotidacin. Based on this translational package of data, a gepotidacin 1,500 mg oral dose twice-daily for 5 days was selected for two ongoing, randomized, multicenter, parallel-group, double-blind, double-dummy, active-comparator phase III clinical studies evaluating the safety and efficacy of gepotidacin in adolescent and adult female participants with uUTIs (NCT04020341 and NCT04187144).

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Premenopausal women with recurrent urinary tract infections have lower quality of life

Cited by 29 publications

References 27 publications

Impact of Recurrent Urinary Infections on the Quality of Life of Women in Outpatient Care: a Case-control Study

Impact of Recurrent Urinary Infections on the Quality of Life of Women in Outpatient Care: a Case-control Study

Relationship between frailty and lower urinary tract symptoms among community‐dwelling adults

Dose Selection for Phase III Clinical Evaluation of Gepotidacin (GSK2140944) in the Treatment of Uncomplicated Urinary Tract Infections

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