Evaluation of idiopathic olfactory loss with chemosensory event‐related potentials and magnetic resonance imaging

Liu, Jia; Pinto, Jayant M.; Yang, Ling; Yao, Le; Miao, Xutao; Wei, Yongxiang

doi:10.1002/alr.22144

Cited by 8 publications

(13 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(5M/14F) 28–57 years Mean age: 45.3 ± 10.2 PIOD = 13 Trauma = 4 Idiopathic ` = 1 20 HC (6M/14F) 24–59 years Mean age: 43.6 ± 14.8 *Right-handed 2–240 months Toyota and Takagi olfactometry (Rombaux et al 2012 ) Belgium 3T Philips Achieva 8-channel 60 Pt. (21M/39F) 24–79 years Mean age: 50 PIOD = 28 Trauma = 32 Sniffin’ Sticks Retronasal psychophysical olfactory tests Idiopathic olfactory loss (Liu et al 2018 ) China 3T Siemens Trio Tim Magnetom 12-channel 20 Pt. (8M/12F) 26–77 years Mean age: 44 ± 12 20 HC (8M/12F) 23–69 years Mean age: 44 ± 12 Mean = 26.4 months 4–96 months Nasal endoscopic and paranasal sinus examination Sniffin’ Sticks Toyota and Takagi olfactometry (Rombaux et al 2010a ) Belgium 1.5T Signa Echospeed, GEMS 22 Pt.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of olfactory-related brain structural changes in patients with congenital or acquired anosmia

et al. 2021

View full text Add to dashboard Cite

Brain structural features of healthy individuals are associated with olfactory functions. However, due to the pathophysiological differences, congenital and acquired anosmia may exhibit different structural characteristics. A systematic review was undertaken to compare brain structural features between patients with congenital and acquired anosmia. A systematic search was conducted using PubMed/MEDLINE and Scopus electronic databases to identify eligible reports on anosmia and structural changes and reported according to PRISMA guidelines. Reports were extracted for information on demographics, psychophysical evaluation, and structural changes. Then, the report was systematically reviewed based on various aetiologies of anosmia in relation to (1) olfactory bulb, (2) olfactory sulcus, (3) grey matter (GM), and white matter (WM) changes. Twenty-eight published studies were identified. All studies reported consistent findings with strong associations between olfactory bulb volume and olfactory function across etiologies. However, the association of olfactory function with olfactory sulcus depth was inconsistent. The present study observed morphological variations in GM and WM volume in congenital and acquired anosmia. In acquired anosmia, reduced olfactory function is associated with reduced volumes and thickness involving the gyrus rectus, medial orbitofrontal cortex, anterior cingulate cortex, and cerebellum. These findings contrast to those observed in congenital anosmia, where a reduced olfactory function is associated with a larger volume and higher thickness in parts of the olfactory network, including the piriform cortex, orbitofrontal cortex, and insula. The present review proposes that the structural characteristics in congenital and acquired anosmia are altered differently. The mechanisms behind these changes are likely to be multifactorial and involve the interaction with the environment. Supplementary Information The online version contains supplementary material available at 10.1007/s00429-021-02397-3.

show abstract

Section: Resultsmentioning

confidence: 99%

A systematic review of olfactory-related brain structural changes in patients with congenital or acquired anosmia

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Several guidelines and multiple expert opinions suggest that the clinical history include the quality of olfactory changes, timing of onset, duration, associated factors, and social and family history. 1123,1124,1127,1128 History of OD requires clarification on the quality of dysfunction (anosmia, hyposmia, dysosmia, parosmia, or phantosmia; definitions described in SECTION III: A-D), laterality (unilateral or bilateral), perceived degree of smell loss (partial or complete), and olfactory status before loss. Information on timing of onset and duration includes whether the patient ever had olfaction (congenital or acquired), sudden or gradual onset, and whether the symptoms are persistent or intermittent.…”

Section: A History and Physical Examinationmentioning

confidence: 99%

“…The majority of studies (nine prospective cohort studies, six case series, and six retrospective studies) agree that OBV is decreased in patients experiencing a wide range of pathologies affecting OF. 1150,1151,1155,1156,[1158][1159][1160]1162,1164,1165,1168,1171,1174,[1177][1178][1179][1180][1181][1182][1183][1184] Indeed, patients with posttraumatic, 1164,1170,1181 postinfectious, 1156,1164 idiopathic, 1150,1155,1160 obstructive, 1150 and congenital 1165,1174 OD were found to have smaller OBVs compared with normosmic controls.…”

Section: Structural Mrimentioning

confidence: 99%

International consensus statement on allergy and rhinology: Olfaction

Patel

Holbrook

Turner

et al. 2022

Int Forum Allergy Rhinol

Self Cite

View full text Add to dashboard Cite

Background:The literature regarding clinical olfaction, olfactory loss, and olfactory dysfunction has expanded rapidly over the past two decades, with an exponential rise in the past year. There is substantial variability in the quality of this literature and a need to consolidate and critically review the evidence. It is with that aim that we have gathered experts from around the world to produce this International Consensus on Allergy and Rhinology: Olfaction (ICAR:O). Methods: Using previously described methodology, specific topics were developed relating to olfaction. Each topic was assigned a literature review, evidence-based review, or evidence-based review with recommendations format as dictated by available evidence and scope within the ICAR:O document. Following iterative reviews of each topic, the ICAR:O document was integrated and reviewed by all authors for final consensus. Results:The ICAR:O document reviews nearly 100 separate topics within the realm of olfaction, including diagnosis, epidemiology, disease burden, diagnosis, testing, etiology, treatment, and associated pathologies. Conclusion:This critical review of the existing clinical olfaction literature provides much needed insight and clarity into the evaluation, diagnosis, and treatment of patients with olfactory dysfunction, while also clearly delineating gaps in our knowledge and evidence base that we should investigate further.

show abstract

“…Of the 19 studies that focused primarily on OB volume in patients with OD, 2 studies looked exclusively at patients with idiopathic OD, 4 with post-infectious OD, 4 with sinonasal OD due to nasal polyposis, 7 with OD of mixed etiologies, and 2 with other etiologies of OD (Supplemental Table 3). 19,21,23,[26][27][28][29][30][31][32][34][35][36][37]40,[44][45][46]48 Overall, of 17 studies that examined OB volume and reported objective olfactory outcomes, 14 (82.4%) reported a significant correlation between one or more measured olfactory outcomes and OB volume. 19,21,[26][27][28]30,[34][35][36][37]40,[44][45][46] Four studies commented on OS depth, of which 3 reported no relationship between OS depth and olfactory outcomes.…”

Section: Structural Pathologiesmentioning

confidence: 99%

Magnetic Resonance Imaging as a Diagnostic and Research Tool in Patients with Olfactory Dysfunction: A Systematic Review

Hura

Lin

et al. 2022

Am J Rhinol�Allergy

View full text Add to dashboard Cite

Background Patients with acquired, idiopathic olfactory dysfunction (OD) commonly undergo magnetic resonance imaging (MRI) evaluation to rule out intracranial pathologies. This practice is highly debated given the expense of MRI relative to the probability of detecting a treatable lesion. This, combined with the increasing use of MRI in research to investigate the mechanisms underlying OD, provided the impetus for this comprehensive review. Objective The purpose of this systematic review was to both assess the utility of MRI in diagnosis of idiopathic OD and to describe MRI findings among mixed OD etiologies to better understand its role as a research tool in this patient population. Methods A literature search of PubMed, Embase, Cochrane, Web of Science, and Scopus for studies with original MRI data for patients with OD was completed. Studies exclusively investigating patients with neurocognitive deficits or those studying traumatic or congenital etiologies of OD were excluded. Results From 1758 candidate articles, 33 studies were included. Four studies reviewed patients with idiopathic OD for structural pathologies on MRI, of which 17 of 372 (4.6%) patients had a potential central cause identified, and 3 (0.8%) had an olfactory meningioma or olfactory neuroblastoma. Fourteen studies (42.4%) reported significant correlation between olfactory bulb volume and olfactory outcomes, and 6 studies (18.8%) reported gray matter volume reduction, specifically in the orbitofrontal cortex, anterior cingulate cortex, insular cortex, parahippocampal, and piriform cortex areas, in patients with mixed OD etiologies. Functional MRI studies reported reduced brain activation and functional connectivity in olfactory network areas. Conclusion MRI uncommonly detects intracranial pathology in patients with idiopathic OD. Among patients with mixed OD etiologies, reduced olfactory bulb and gray matter volume are the most common abnormal findings on MRI. Further research is required to better understand the role of MRI and its cost-effectiveness in patients with acquired, idiopathic OD.

show abstract

Evaluation of idiopathic olfactory loss with chemosensory event‐related potentials and magnetic resonance imaging

Cited by 8 publications

References 34 publications

A systematic review of olfactory-related brain structural changes in patients with congenital or acquired anosmia

A systematic review of olfactory-related brain structural changes in patients with congenital or acquired anosmia

International consensus statement on allergy and rhinology: Olfaction

Magnetic Resonance Imaging as a Diagnostic and Research Tool in Patients with Olfactory Dysfunction: A Systematic Review

Contact Info

Product

Resources

About