Single Versus Standard Multiview Assessment of Global Longitudinal Strain for the Diagnosis of Cardiotoxicity During Cancer Therapy

Thavendiranathan, Paaladinesh; Negishi, Tomoko; Côté, Mélissa; Pěnička, Martin; Massey, Richard J.; Cho, Goo-Yeong; Vinereanu, Dragoş; Popescu, Bogdan A; Izumo, Masaki; Negishi, Kazuaki; Marwick, Thomas H.; Investigators, Succour

doi:10.1016/j.jcmg.2018.03.003

Cited by 44 publications

(31 citation statements)

References 12 publications

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“…The ongoing SUCCOUR study is prospectively assessing the value of initiating cardioprotective medication triggered by the reduction of GLS vs. waiting for a decline in 3D LVEF 19 . GLS should be based on three apical (long‐axis) views and not replaced by single‐view longitudinal strain due to substantial disagreement in the diagnosis of cardiotoxicity 20 . Although less feasible and reproducible, 2D‐ or 3D‐derived global circumferential strain may also serve as additional markers of myocardial dysfunction but require more studies for validation 21,22 .…”

Section: General Principlesmentioning

confidence: 99%

Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio‐Oncology Council of the European Society of Cardiology (ESC)

Čelutkienė

Pudil

López‐Fernández

et al. 2020

European J of Heart Fail

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264

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Cardiovascular (CV) imaging is an important tool in baseline risk assessment and detection of CV disease in oncology patients receiving cardiotoxic cancer therapies. This position statement examines the role of echocardiography, cardiac magnetic resonance, nuclear cardiac imaging and computed tomography in the management of cancer patients. The Imaging and Cardio-Oncology Study Groups of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) in collaboration with the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the ESC have evaluated the current evidence for the value of modern CV imaging in the cardio-oncology field. The most relevant echocardiographic parameters, including global longitudinal strain and three-dimensional ejection fraction, are proposed. The protocol for baseline pre-treatment evaluation and specific surveillance algorithms or pathways for anthracycline chemotherapy, HER2-targeted therapies such as trastuzumab, vascular endothelial growth factor tyrosine kinase inhibitors, BCr-Abl tyrosine kinase inhibitors, proteasome inhibitors and immune checkpoint inhibitors are presented. The indications for CV imaging after completion of oncology treatment are considered. The typical consequences of radiation therapy and the possibility of their identification in the long term are also summarized. Special populations are discussed including female survivors planning pregnancy, patients with carcinoid disease, patients with cardiac tumours and patients with right heart failure. Future directions and ongoing CV imaging research in cardio-oncology are discussed.

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Section: General Principlesmentioning

confidence: 99%

Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio‐Oncology Council of the European Society of Cardiology (ESC)

Čelutkienė

Pudil

López‐Fernández

et al. 2020

European J of Heart Fail

Self Cite

264

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“…Age-related studies have been reported (28). Both 2DSTE and 3DSTE showed to be more sensitive to identify subtle myocardial damage compared to standard indices of LV function (29)(30)(31). Advantages and disadvantages of 3D over 2D speckle tracking have been previously discussed (16,17).…”

Section: Discussionmentioning

confidence: 97%

“…The recognition of clinically significant abnormal values of ventricular strain is not easy because the index is influenced by age, sex, and loading conditions. Current guidelines on chemotherapy-related cardiotoxicity suggest a cardiac assessment based on GLS cutoffs at baseline because a GLS decrease compared to the patient's baseline value is better justified than the use of an absolute cutoff (30,31).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Biventricular Function by Three-Dimensional Speckle Tracking Echocardiography in Adolescents and Young Adults with Human Immunodeficiency Virus Infection: A Pilot Study

et al. 2019

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Background. The purpose of the study was to assess biventricular parameters of wall deformation with three-dimensional speckle tracking echocardiography (3DSTE) in adolescents and young adults with human immunodeficiency virus infection (HIV) on antiretroviral therapy in order to detect a possible subclinical myocardial dysfunction. Methods. Twenty-one patients aged 12 to 39years with HIV, 21 normal controls of the same age and sex, and 21 patients with idiopathic non-ischemic dilated cardiomyopathy (DCM) were studied with 3DSTE. All HIV patients were stable in terms of HIV infection, with no history of heart disease or other chronic systemic disease except HIV infection, and were on highly active antiretroviral therapy (HAART) with good immunological control. Standard echocardiographic measures of LV-RV function were assessed. 3D LV global longitudinal strain (GLS), circumferential strain, radial strain and LV twist (TW) were calculated. Global area strain (GAS) was calculated by 3DSTE as percentage variation in surface area defined by the longitudinal and circumferential strain vectors. 3D right ventricular (RV) global and free-wall longitudinal strain were obtained. Results. LV GLS and GAS were lower in HIV patients compared to normal controls (p=0.002, and p=0.01, respectively). There were no significant differences in LV ejection fractions between the groups. There was a weak positive correlation between LV GLS and age (r=0.215, p=0.034) and a weak negative correlation between LV GLS and nadir-CD4 T-cells count (r=0.198, p=0.043). DCM patients had more marked and widespread reduction in LV GLS and GAS compared to controls (p<0.001), whereas in HIV patients LV strain impairment (p<0.05) was more localized in basal and apical regions. RV free-wall longitudinal strain was significantly reduced in HIV patients when compared with the control group (p=0.03). No patient had pulmonary systolic pressure higher than 35mmHg. Conclusions. Three-dimensional speckle tracking echocardiography may help to identify HIV patients at high cardiovascular risk allowing early detection of biventricular dysfunction in the presence of normal LV ejection fraction and in the absence of pulmonary hypertension. LV strain impairment in HIV patients is less prominent and widespread compared to DCM patients.

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“…One such study showed good agreement and similar prognostic value of 4ch GLS and three plane GLS in heart failure patients [ 18 ]. Another study aimed at detecting cardiotoxicity was conducted in patients undergoing chemotherapy [ 19 ]. This study also found good agreement between three plane GLS and 4ch GLS, but nuanced this by showing some discordance regarding threshold values of cardiotoxicity for these two models in addition to lower reproducibility for 4ch GLS.…”

Section: Discussionmentioning

confidence: 99%

Speckle tracking derived strain in neonates: planes, layers and drift

Khan

Omdal

Matre

et al. 2021

Int J Cardiovasc Imaging

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The aims of this study was to assess the effect of using a four chamber versus a three plane model on speckle tracking derived global longitudinal strain, the effects of drift compensation, the effect of assessing strain in different layers and finally the interplay between these aspects for the assessment of strain in neonates. Speckle tracking derived longitudinal strain was obtained from 22 healthy neonates. ANOVA, Bland–Altman analyses, coefficients of variation and assessment of intraclass correlation coefficients were conducted to assess the effect of the abovementioned aspects as well as assess both inter-observer and intra-observer variability. Neither the use of the three plane model versus the four chamber model nor the use of drift compensation had a substantial effect on global longitudinal strain (less than 1%, depending on which layer was being assessed). A gradient was seen with increasing strain from the epicardial to endocardial layers, similar to what is seen in older subjects. Finally, drift compensation introduced more discrepancy in segmental strain values compared to global longitudinal strain. Global longitudinal strain in healthy neonates remains reasonably consistent regardless of whether the three plane or four chamber model is used and whether drift compensation is applied. Its value increases when one moves from the endocardial to the epicardial layer. Finally, drift compensation introduces more discrepancy for regional measures of longitudinal strain compared to global longitudinal strain.

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Single Versus Standard Multiview Assessment of Global Longitudinal Strain for the Diagnosis of Cardiotoxicity During Cancer Therapy

Cited by 44 publications

References 12 publications

Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio‐Oncology Council of the European Society of Cardiology (ESC)

Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio‐Oncology Council of the European Society of Cardiology (ESC)

Assessment of Biventricular Function by Three-Dimensional Speckle Tracking Echocardiography in Adolescents and Young Adults with Human Immunodeficiency Virus Infection: A Pilot Study

Speckle tracking derived strain in neonates: planes, layers and drift

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