Association of objectively measured physical activity with brain structure: UK Biobank study

Hamer, Mark; Sharma, Nikhil; Batty, G. David

doi:10.1111/joim.12772

Cited by 59 publications

(66 citation statements)

References 21 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… 10 , 26 Our results are consistent with a study in the UK Biobank that observed significant associations only in participants younger than 60 years. 17 …”

Section: Discussionmentioning

confidence: 99%

“… 12 Furthermore, cross-sectional epidemiologic studies have established an association of physical inactivity with brain aging. 4 , 13 , 14 , 15 , 16 , 17 , 18 However, further work is needed to pinpoint the optimal dosage (duration × intensity) of PA needed to promote healthy brain aging. Although this question cannot be fully addressed in an observational study, our investigation sheds light on the dosage of PA most strongly associated with favorable brain structure in a community setting.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume

et al. 2019

View full text Add to dashboard Cite

Key Points Question Is light-intensity physical activity associated with brain volume? Findings In this community-based cohort study of 2354 participants, each additional hour spent in light-intensity physical activity was associated with larger brain volume, equivalent to approximately 1.1 years less brain aging. Achieving 10 000 or more steps per day was associated with higher brain volume compared with those achieving fewer than 5000 steps per day. Meaning Incremental physical activity, even at a more practical light intensity, may be involved in the maintenance of brain structures into older age.

show abstract

“… 10 , 26 Our results are consistent with a study in the UK Biobank that observed significant associations only in participants younger than 60 years. 17 …”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Notably, more than 80% of reviewed studies did not control for lifestyle differences. Physical activity may impact brain structures and functions [93,94]. Given that patients with ME/CFS have to reduce their daily activities because of fatigue, objective measurement of physical activity in both patients and controls is essential to differentiate between brain differences that are unique in ME/CFS and those due to reduced physical activity.…”

Section: Discussionmentioning

confidence: 99%

Neuroimaging characteristics of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review

et al. 2020

View full text Add to dashboard Cite

Background: Since the 1990s, neuroimaging has been utilised to study Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a debilitating illness with unknown aetiology. While brain abnormalities in ME/CFS have been identified, relatively little is known regarding which specific abnormalities are consistently observed across research groups and to what extent the observed abnormalities are reproducible. Method: To identify consistent and inconsistent neuroimaging observations in ME/CFS, this retrospective and systematic review searched for studies in which neuroimaging was used to investigate brain abnormalities in ME/CFS in Ovid MEDLINE, PubMed (NCBI), and Scopus from January 1988 to July 2018. A qualitative synthesis of observations was performed to identify brain abnormalities that were consistently and inconsistently reported. Results: 63 full-text articles were included in the synthesis of results from 291 identified papers. Additional brain area recruitment for cognitive tasks and abnormalities in the brain stem are frequent observations in 11 and 9 studies using different modalities from different research teams respectively. Also, sluggish blood oxygenation level-dependent (BOLD) signal responses to tasks, reduced serotonin transporters, and regional hypometabolism are consistent observations by more than two research teams. Single observations include abnormal brain tissue properties, regional metabolic abnormalities, and association of brain measures with ME/CFS symptoms. Reduced resting cerebral blood flow and volumetric brain changes are inconsistent observations across different studies. Conclusion: Neuroimaging studies of ME/CFS have frequently observed additional brain area recruitment during cognitive tasks and abnormalities in the brain stem. The frequent observation of additional brain area recruitment and consistent observation of sluggish fMRI signal response suggest abnormal neurovascular coupling in ME/CFS.

show abstract

“…Notably, this association was only observed within the group of participants over 51 years of age. In line with this, positive associations have previously been reported between total gray matter volume and sensor-measured physical activity, but only among adults over 60 years of age (Hamer et al, 2018). Further, while evidence of the positive long-term effects on cognition and the brain of MVPA is moderately strong among adults aged 50 years or older, the evidence is insufficient among adults younger than 50 years of age (Physical Activity Guidelines Advisory Committee, 2018).…”

Section: Figure 3 | (A)mentioning

confidence: 77%

Walking Time Is Associated With Hippocampal Volume in Overweight and Obese Office Workers

Bergman

Matsson-Frost

Jonasson

et al. 2020

Front. Hum. Neurosci.

View full text Add to dashboard Cite

Objectives: To investigate the long-term effects on cognition and brain function after installing treadmill workstations in offices for 13 months. Methods: Eighty healthy overweight or obese office workers aged 40-67 years were individually randomized to an intervention group, receiving a treadmill workstation and encouraging emails, or to a control group, continuing to work as usual. Effects on cognitive function, hippocampal volume, prefrontal cortex (PFC) thickness, and circulating brain-derived neurotrophic factor (BDNF) were analyzed. Further, mediation analyses between changes in walking time and light-intensity physical activity (LPA) on changes in BDNF and hippocampal volume between baseline and 13 months, and multivariate analyses of the baseline data with percentage sitting time as the response variable, were performed. Results: No group by time interactions were observed for any of the outcomes. In the mediation analyses, positive associations between changes in walking time and LPA on changes in hippocampal volume were observed, although not mediated by changes in BDNF levels. In the multivariate analyses, a negative association between percentage sitting time and hippocampal volume was observed, however only among those older than 51 years of age. Conclusion: Although no group by time interactions were observed, our analyses suggest that increased walking and LPA may have positive effects on hippocampal volume and that sedentary behavior is associated with brain structures of importance for memory functions. Trial Registration: www.ClinicalTrials.gov as NCT01997970.

show abstract

Association of objectively measured physical activity with brain structure: UK Biobank study

Abstract: In summary, physical activity may play a role in the prevention of neurodegenerative diseases.

Cited by 59 publications

References 21 publications

Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume

Association of Accelerometer-Measured Light-Intensity Physical Activity With Brain Volume

Neuroimaging characteristics of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review

Walking Time Is Associated With Hippocampal Volume in Overweight and Obese Office Workers

Contact Info

Product

Resources

About