Lysophosphatidylcholine as a predictor of postoperative complications after colorectal cancer surgery

Matsuda, Akihisa; Yamada, Marina; Matsumoto, Satoshi; Sakurazawa, Nobuyuki; Yamada, Takeshi; Matsutani, Takeshi; Miyashita, Masao; Uchida, Eiji

doi:10.1007/s00595-018-1675-2

Cited by 16 publications

(9 citation statements)

References 41 publications

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“…In this cohort, the proportion of patients of male sex, with a low serum albumin concentration, and with a prolonged operative time, which are traditionally considered predictors of postoperative complications, was significantly higher in the group with complications of CDc grade ≥II (22,23). Various risk factors and predictors of postoperative complications in gastrointestinal surgical diseases have been reported (24,25).…”

Section: Discussionmentioning

confidence: 76%

The Barthel Index for Predicting Postoperative Complications in Elderly Patients Undergoing Abdominal Surgery: A Prospective Single-center Study

Uchinaka

Hanaki

Morimoto

et al. 2022

In Vivo

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Background/Aim: The Barthel index and Katz index are useful in assessing the physical function status of patients. We prospectively evaluated the relationship between the Barthel and Katz indices and postoperative complications in older patients undergoing gastrointestinal surgery. Patients and Methods: We enrolled 250 patients aged ≥65 years who underwent gastrointestinal surgery between September 2018 and April 2020. Postoperative complications within 30 days after surgery were categorized using the Clavien-Dindo classification. The primary endpoint was the incidence of postoperative complications of Clavien-Dindo grade ≥II. Results: Of the 250 patients (age, 74.1±6.2 years), 149 (59.6%) were male and 101 (40.4%) were female. The Barthel index was <100 in 49 patients (19.6%), and the Katz index was B-G in 23 patients (9.2%). Seventy-five patients (30%) developed postoperative complications of Clavien-Dindo grade ≥I, and 72 patients (28.8%) developed complications of Clavien-Dindo grade ≥II within 30 days after surgery. A Barthel index of <100 was more common in the group with complications, while the Katz index did not differ. A Barthel index of <100 was also a significant multivariate predictor of complications of Clavien-Dindo grade ≥II. Conclusion: The Barthel index is a useful predictor of postoperative complications in older individuals undergoing gastrointestinal surgery.

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Section: Discussionmentioning

confidence: 76%

The Barthel Index for Predicting Postoperative Complications in Elderly Patients Undergoing Abdominal Surgery: A Prospective Single-center Study

Uchinaka

Hanaki

Morimoto

et al. 2022

In Vivo

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“…Lysophosphatidylcholines in plasma mainly derive from phosphatidylcholines or lipoproteins. Metsuda et al reported that decreased lysophosphatidylcholine levels were associated with postoperative inflammation and complications [ 47 ]. In healthy subjects, lysophosphatidylcholine concentrations are reported to be around 200–300 μM [ 48 ], while in our cohort the sum of all measured lysophosphatidylcholines was only 91.8 μM.…”

Section: Discussionmentioning

confidence: 99%

Perioperative changes in the plasma metabolome of patients receiving general anesthesia for pancreatic cancer surgery

et al. 2021

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Background: Modern anesthesia strives to offer personalized concepts to meet the patient's individual needs in sight of clinical outcome. Still, little is known about the impact of anesthesia on the plasma metabolome, although many metabolites have been shown to modulate the function of various immune cells, making it particularly interesting in the context of oncological surgery. In this study longitudinal dynamics in the plasma metabolome during general anesthesia in patients undergoing pancreatic surgery were analyzed.Materials and Methods: Prospective, observational study with 10 patients diagnosed with pancreatic (pre-) malignancy and subjected to elective resection surgery under general anesthesia. Plasma metabolites (n = 630) were quantified at eight consecutive perioperative timepoints using mass spectrometry-based targeted metabolomics.Results: 39 metabolites significantly changed during the perioperative period. Tryptophan concentrations decreased by 45% with the maximum decrease after anesthesia induction (p = 6.24E-07), while taurine synthesis increased (p = 1.46E-04). Triacylglycerides and lysophosphatidylcholines were significantly reduced with increased liberation of free monounsaturated fatty acids (p = 0.03). Carnitine levels decreased significantly (p = 9.30E-04).Conclusions: The major finding of this study was perioperative tryptophan depletion and increased taurine synthesis. Both are essential for immune cell function and are therefore of significant interest for perioperative management. Further studies are needed to identify influencing anesthetic factors.

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“…More recently, another trend of treatment has been emerging. According to Matsuda et al [17], no significant differences between the two options of treatment in terms of overall survival were apparent. Abdominoperineal resection has failed to show any advantage in terms of survival, adding a higher morbidity and poorer quality of life.…”

Section: Melanoma Of the Anorectummentioning

confidence: 95%

Appendiceal Neuroendocrine Tumors and Anorectal Melanoma

Clementi¹,

Pietroletti²,

Ciarrocchi³

et al. 2020

Tumor Progression and Metastasis

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Tumor growth and spread are a complicated matter and are the result of many interconnected factors. The analysis of patterns emerging from highly numerous populations might help shed some light on such an intricate mechanism. In this respect, our studies are mostly based on the SEER database, a nation representative dataset collecting data regarding the US population, over a very long time span. This approach is revealed to be particularly useful for rare tumors, as prospective studies are not feasible. Here, we present the results and the clinical implications of our inquires: we show the impact on overall survival of several morphological and demographic characteristics of various malignancies including anorectal melanoma and neuroendocrine tumors of the appendix. The impact of surgical treatment is discussed as well. Finally, we endorse the need to find more reliable markers of tumor biology, such as genetic patterns, to tailor an effective multidisciplinary treatment.

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Lysophosphatidylcholine as a predictor of postoperative complications after colorectal cancer surgery

Abstract: Decreased postoperative LPC is associated with increased postoperative inflammatory response and POCs. The decreased PC supply to the circulation is a mechanism of the postoperative LPC decrease.

Cited by 16 publications

References 41 publications

The Barthel Index for Predicting Postoperative Complications in Elderly Patients Undergoing Abdominal Surgery: A Prospective Single-center Study

The Barthel Index for Predicting Postoperative Complications in Elderly Patients Undergoing Abdominal Surgery: A Prospective Single-center Study

Perioperative changes in the plasma metabolome of patients receiving general anesthesia for pancreatic cancer surgery

Appendiceal Neuroendocrine Tumors and Anorectal Melanoma

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