Adolescent and young adult oncology patients in France: Heterogeneity in pathways of care

Désandes, Emmanuel; Brugières, Laurence; Molinié, F.; Défossez, Gautier; Delafosse, Patricia; Jéhannin-Ligier, Karine; Velten, Michel; Trétarre, Brigitte; Amadéo, Brice; Marrer, Émilie; Woronoff, Anne‐Sophie; Ganry, O.; Monnereau, Alain; d’Almeida, Tania; Troussard, Xavier; Daubisse‐Marliac, Laetitia; Bara, Simona; Guizard, Anne‐Valérie; Baldi, Isabelle; Launoy, Guy; Clavel, Jacqueline; Lacour, Brigitte

doi:10.1002/pbc.27235

Cited by 8 publications

(6 citation statements)

References 23 publications

(55 reference statements)

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“…Ferrari et al (n=575) established that children over 10 years old had a longer total interval than those younger than 10 years old 67. Desandes et al (n=43) found the same result when comparing age groups 15–19 vs 20–24 years (15.4 vs 48.7 weeks; p=0.04) 35. Smolle et al found no difference for patients with synovial sarcoma older or younger than 16 years old 68.…”

Section: Resultsmentioning

confidence: 92%

“…Six studies reported a significantly longer total interval for older teenagers, adolescents or adults compared with younger children or (younger) teenagers (<12 vs ≥12–22 years1122; <20 vs ≥20–86 years26; <22 vs ≥22 years27; 0–14 vs 15–19 vs 20–29 years40; <12 versus ≥12 years11). Furthermore, Desandes et al found young adults were more at risk for a longer total interval than patients in puberty (15–19 vs 20–24 years; 10.1 vs 21.4 weeks respectively; p=0.04) 35. Lawrenz et al (n=1792) investigated age (mean 30.7 years) as a continuous variable and reported every additional year of age was associated with a 1.3 weeks longer total interval (p<0.00) 41.…”

Section: Resultsmentioning

confidence: 99%

“…Thirty-four studies involving a total of 17 258 patients investigated the total interval in BS (table 1)8–41; five of these studies prospectively collected follow-up data. A broad range in the length of the total interval was found, which varied from 9 to 120.4 weeks.…”

Section: Resultsmentioning

confidence: 99%

“…Thirty-six studies investigated the total interval for STS (table 3). 27 30–35 38 42–69 A combined total of 16 845 patients were included and, reflecting STS heterogeneity, the total interval varied tremendously; between 4.3 and 614.9 weeks.…”

Section: Resultsmentioning

confidence: 99%

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The sarcoma diagnostic interval: a systematic review on length, contributing factors and patient outcomes

et al. 2020

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Sarcomas are rare and heterogeneous mesenchymal tumours of soft tissue or bone, making them prone to late diagnosis. In other malignancies, early diagnosis has an impact on stage of disease, complexity of therapeutic procedures, survival and health-related quality of life (HRQoL). Little is known about what length of diagnostic interval should be considered as delay in patients with bone (BS) or soft tissue sarcomas (STS). To quantify total interval (defined as time from first symptom to histological diagnosis) and its components, identify contributing factors to its length and determine the impact on patients’ outcome in terms of mortality and HRQoL. A systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Seventy-six articles out of 2310 met the predefined inclusion criteria. Total intervals, varied broadly; 9–120.4 weeks for BS and 4.3–614.9 weeks for STS. Older age and no initial radiological examinations were contributing factors for a long interval in BS, while in STS results were conflicting. The impact of length of total interval on clinical outcomes in terms of survival and morbidity remains ambiguous; no clear relation could be identified for both BS and STS. No study examined the impact on HRQoL. The length of total interval is variable in BS as well as STS. Its effect on outcomes is contradictory. There is no definition of a clinically relevant cut-off point that discriminates between a short or long total interval. Prospero: CRD42017062492.

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Section: Resultsmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The sarcoma diagnostic interval: a systematic review on length, contributing factors and patient outcomes

et al. 2020

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“…Dans un contexte de parcours de soins des AJA qui reste hétérogène (certains étant pris en charge en hématologie-oncologie pédiatrique, d'autres dans des services de médecine adulte) [1,3], nous avons étudié l'accès à la préservation de la fertilité des AJA atteints de pathologies cancéreuses au CHU de Clermont-Ferrand sur une période de 3 ans.…”

Section: Introductionunclassified

Accès à la préservation de la fertilité des adolescents et jeunes adultes de 15 à 24 ans atteints de cancers en Auvergne, France

et al. 2020

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Introduction: Cancers of adolescents and young adults have particular epidemiological specificities. The improvement in their survival should be accompanied by an increased consideration of the treatments' side effects, among which the potential decrease in fertility.The objective of the study was to describe the access to fertility preservation of these patients at the University Hospital of Clermont-Ferrand over a period of 3 years. Methods: During this retrospective descriptive study, various socio-demographic and clinical data were collected.Results: One hundred and fifty new cases of cancers were diagnosed in patients aged 15 to 24 years. Forty-four percent received at least one fertility consultation, 29% for girls and 58% for boys (p < 0.001). The number of cases that did not result in fertility preservation was significantly higher for girls than boys (p = 0.005). Fertility preservation was mainly achieved by cryopreservation of ovarian tissue in female adolescents, ovocytes in young women and sperm in boys. Discussion: We observed sex disparities in access to fertility preservation. Despite the existence of recommendations, progress remains to be made. The establishment of clinicobiological platforms should allow a better awareness of patients and professionals, and thus promote access to fertility preservation techniques for young patients with cancer.

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Collaboration pédiatre-adulte dans la chirurgie des tumeurs musculosquelettiques

Laurence

Hamel²,

Mascard

2021

Bulletin du Cancer

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Adolescent and young adult oncology patients in France: Heterogeneity in pathways of care

Abstract: In France, pathways of care for AYAs are heterogeneous. It is necessary to organize a national network of expert centers with adequate medical skills and specific psychosocial support and facilities to provide the best possible care for these patients.

Cited by 8 publications

References 23 publications

The sarcoma diagnostic interval: a systematic review on length, contributing factors and patient outcomes

The sarcoma diagnostic interval: a systematic review on length, contributing factors and patient outcomes

Accès à la préservation de la fertilité des adolescents et jeunes adultes de 15 à 24 ans atteints de cancers en Auvergne, France

Collaboration pédiatre-adulte dans la chirurgie des tumeurs musculosquelettiques

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