Consumption of pomegranate decreases plasma lipopolysaccharide-binding protein levels, a marker of metabolic endotoxemia, in patients with newly diagnosed colorectal cancer: a randomized controlled clinical trial

González‐Sarrías, Antonio; Núñez‐Sánchez, María Ángeles; Ávila‐Gálvez, María Ángeles; Monedero‐Saiz, Tamara; Rodríguez‐Gil, Francisco J.; Martínez‐Díaz, Francisco; Selma, María V.; Espı́n, Juan Carlos

doi:10.1039/c8fo00264a

Cited by 35 publications

(25 citation statements)

References 33 publications

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“…Remarkably, these effects were not associated with urolithin concentrations in plasma, urine, or feces. This agrees with other studies that also explored the association between urolithin occurrence in plasma, urine, feces or colonic tissues and cancer‐related markers and metabolic endotoxemia in colorectal cancer patients ( n = 45), [ 173,174 ] metabolic endotoxemia in overweight‐obese individuals ( n = 49), [ 175 ] and blood lipid profile in healthy subjects ( n = 32). [ 176 ] Overall, the lack of clear association is plausible due to the highly variable turnover of these microbial metabolites and their occurrence in the bloodstream and other biological reservoirs, especially in studies with a design of short‐term follow‐up to observe acute effects (hours or few days).…”

Section: Human Polyphenol‐related Metabotypes As Biomarkers Of the Gusupporting

confidence: 90%

Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes

Cortés‐Martín

Selma

Tomás‐Barberán

et al. 2020

Molecular Nutrition Food Res

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173

206

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The full consensus on the role of dietary polyphenols as human-healthpromoting compounds remains elusive. The two-way interaction between polyphenols and gut microbiota (GM) (i.e., modulation of GM by polyphenols and their catabolism by the GM) is determinant in polyphenols' effects. The identification of human metabotypes associated with a differential gut microbial metabolism of polyphenols has opened new research scenarios to explain the inter-individual variability upon polyphenols consumption. The metabotypes unequivocally identified so far are those involved in the metabolism of isoflavones (equol and(or) O-desmethylangolesin producers versus non-producers) and ellagic acid (urolithin metabotypes, including producers of only urolithin-A (UM-A), producers of urolithin-A, isourolithin-A, and urolithin-B (UM-B), and non-producers (UM-0)). In addition, the microbial metabolites (phenolic-derived postbiotics) such as equol, urolithins, valerolactones, enterolactone, and enterodiol, and 8-prenylnaringenin, among others, can exert differential health effects. The knowledge is updated and position is taken here on i) the two-way interaction between GM and polyphenols, ii) the evidence between phenolic-derived postbiotics and health, iii) the role of metabotypes as biomarkers of GM and the clustering of individuals depending on their metabotypes (metabotyping) to explain polyphenols' effects, and iv) the gut microbial metabolism of catecholamines to illustrate the intersection between personalized nutrition and precision medicine.A. Cortés-Martín, Dr.

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Section: Human Polyphenol‐related Metabotypes As Biomarkers Of the Gusupporting

confidence: 90%

Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes

Cortés‐Martín

Selma

Tomás‐Barberán

et al. 2020

Molecular Nutrition Food Res

Self Cite

173

206

View full text Add to dashboard Cite

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“…The increase in LPS is associated with bacterial translocation due to the impairment of intestinal epithelial cell [49]. Previous study has found that gut microbiota dysbiosis alters the intestinal barrier function, increases plasma LPS levels, which promotes endotoxemia, and contributes to the onset and development of CRC [50]. Our study also found that the concentration of LPS increased significantly in CRC patients, which was correlated with Lactobacillus, Bifidobacterium, and Clostridium cluster I negatively and with F. nucleatum and Enterobacteriaceae positively.…”

Section: Discussionmentioning

confidence: 99%

Alterations of the Predominant Fecal Microbiota and Disruption of the Gut Mucosal Barrier in Patients with Early-Stage Colorectal Cancer

Liu

Cheng

et al. 2020

BioMed Research International

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Growing evidence indicated that the gut microbiota was the intrinsic and essential component of the cancer microenvironment, which played vital roles in the development and progression of colorectal cancer (CRC). In our present study, we investigated the alterations of fecal abundant microbiota with real-time quantitative PCR and the changes of indicators of gut mucosal barrier from 53 early-stage CRC patients and 45 matched healthy controls. We found that the traditional beneficial bacteria such as Lactobacillus and Bifidobacterium decreased significantly and the carcinogenic bacteria such as Enterobacteriaceae and Fusobacterium nucleatum were significantly increased in CRC patients. We also found gut mucosal barrier dysfunction in CRC patients with increased levels of endotoxin (LPS), D-lactate, and diamine oxidase (DAO). With Pearson’s correlation analysis, D-lactate, LPS, and DAO were correlated negatively with Lactobacillus and Bifidobacterium and positively with Enterobacteriaceae and F. nucleatum. Our present study found dysbiosis of the fecal microbiota and dysfunction of the gut mucosal barrier in patients with early-stage CRC, which implicated that fecal abundant bacteria and gut mucosal barrier indicators could be used as targets to monitor the development and progression of CRC in a noninvasive and dynamic manner.

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“…Gut microbiota dysbiosis impairs the intestinal barrier function and elevates plasma lipopolysaccharide levels, thereby promoting endotoxemia and contributing to the development of CRC. The reduction in plasma LBP levels may be a crucial parameter for patients newly diagnosed with CRC (51). Additionally, LBP may also be useful in renal cancer (52).…”

Section: Discussionmentioning

confidence: 99%

Proteomics profiling of plasma exosomes in epithelial ovarian cancer: A potential role in the coagulation cascade, diagnosis and prognosis

Zhang

2019

Int J Oncol

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Ovarian cancer remains the most lethal type of cancer among all gynecological malignancies. The majority of patients are diagnosed with ovarian cancer at the late stages of the disease. Therefore, there exists an imperative need for the development of early ovarian cancer diagnostic techniques. Exosomes, secreted by various cell types, play pivotal roles in intercellular communication, which emerge as promising diagnostic and prognostic biomarkers for ovarian cancer. In this study, we present for the first time, at least to the best of our knowledge, the proteomics profiling of exosomes derived from the plasma of patients with ovarian cancer via liquid chromatography tandem mass spectrometry (LC-MS/MS) with tandem mass tagging (TMT). The exosomes enriched from patient plasma samples were characterized by nanoparticle tracking analysis (NTA), dynamic light scattering (DLS), transmission electron microscopy (TEM) and western blot analysis. The size of the plasma exosomes fell into the range of 30 to 100 nm in diameter. The exosomal marker proteins, CD81 and TSG101, were clearly stained in the exosome samples; however, there was no staining for the endoplasmic reticulum protein, calnexin. A total of 294 proteins were identified with all exosome samples. Among these, 225 proteins were detected in both the cancerous and non-cancerous samples. Apart from universal exosomal proteins, exosomes derived from ovarian cancer patient plasma also contained tumor-specific proteins relevant to tumorigenesis and metastasis, particularly in epithelial ovarian carcinoma (EOC). Patients with EOC often suffer from coagulation dysfunction. The function of exosomes in coagulation was also examined. Several genes relevant to the coagulation cascade were screened out as promising diagnostic and prognostic factors that may play important roles in ovarian cancer progression and metastasis. On the whole, in this study, we successfully isolated and purified exosomes from plasma of patients with EOC, and identified a potential role of these exosomes in the coagulation cascade, as well as in the diagnosis and prognosis of patients. differentially expressed genes, functional enrichment analysis, protein-protein interaction, diagnostic and prognostic biomarkers

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Consumption of pomegranate decreases plasma lipopolysaccharide-binding protein levels, a marker of metabolic endotoxemia, in patients with newly diagnosed colorectal cancer: a randomized controlled clinical trial

Cited by 35 publications

References 33 publications

Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes

Where to Look into the Puzzle of Polyphenols and Health? The Postbiotics and Gut Microbiota Associated with Human Metabotypes

Alterations of the Predominant Fecal Microbiota and Disruption of the Gut Mucosal Barrier in Patients with Early-Stage Colorectal Cancer

Proteomics profiling of plasma exosomes in epithelial ovarian cancer: A potential role in the coagulation cascade, diagnosis and prognosis

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