Low PG I/II ratio as a marker of atrophic gastritis

Su, Weiwei; Zhou, Bin; Qin, Guangming; Chen, Zhihao; Geng, Xiaoge; Chen, Xiaojun; Pan, Wensheng

doi:10.1097/md.0000000000010820

Cited by 11 publications

(6 citation statements)

References 26 publications

(27 reference statements)

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“…We observed that the success of WMT in eradicating H. pylori infection appeared to be associated with an increased PGR detected within 1 week prior to WMT. It has been demonstrated that a low PGR is a biomarker of precancerous lesions, such as atrophic gastritis, and thus indicates a high risk of developing gastric cancer [ 34 – 36 ]. Our observation suggests that WMT may have a therapeutic effect on H. pylori infection in patients with low risk of gastric cancer and those with high risk of gastric cancer may not benefit from WMT.…”

Section: Discussionmentioning

confidence: 99%

The Efficacy of Washed Microbiota Transplantation on Helicobacter pylori Eradication: A Pilot Study

Xia

Zhang

et al. 2020

Gastroenterology Research and Practice

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Aim. The fecal microbiota transplantation by washed preparation was recently coined as washed microbiota transplantation (WMT). This pilot study is aimed at exploring the feasibility and efficacy of WMT on Helicobacter pylori eradication. Methods. Consecutive patients who had been treated with WMT for various indications and who were positive for H. pylori infection before WMT treatment but had never received eradication therapy for H. pylori infection were invited to take a follow-up 13C-urea breath test. The associations of demographic, clinical factors, and laboratory indicators for gastric function and intestinal barrier function with the therapeutic effect were determined. Results. A total of 32 eligible patients were included, and the overall H. pylori eradication rate was 40.6% (13/32). Patients with H. pylori eradication had a higher pepsinogen ratio (PGR) than those without ( 13.00 ± 6.97 vs. 8.31 ± 3.733 ; P = 0.02 ). Female patients had a higher, albeit not statistically significant, eradication rate than male patients (53.85% vs. 31.58%; P = 0.208 ). Compared with lower gastrointestinal tract delivery route, middle gastrointestinal tract delivery route seems to be a more suitable way for the treatment of H. pylori infection (58.33% vs 16.67%; P = 0.152 ). There was no significant difference in other demographic and clinical factors between patients with and without H. pylori eradication. Conclusion. H. pylori infection is eradicated in a proportion of patients who have received WMT. An increased pre-WMT PGR appears to be associated with the therapeutic effect. Further studies are required to confirm the efficacy of WMT, especially in combination with currently recommended regimens in randomized controlled trials.

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Section: Discussionmentioning

confidence: 99%

The Efficacy of Washed Microbiota Transplantation on Helicobacter pylori Eradication: A Pilot Study

Xia

Zhang

et al. 2020

Gastroenterology Research and Practice

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“…The main function of G-17 is to stimulate the secretion of gastric acid by the parietal cells of the gastric body, as well as to increase the motility of the gastric antrum. Thus, serum PG levels, primarily the combination of PG-I and PGR, with or without G-17 and HP-IgG determination, can be used to reflect morphological aspects, the functional (secretory) state of the gastric mucosa and to predict the development of GC [ 4 , 6 – 11 , 14 – 16 , 29 , 32 – 35 ].…”

Section: Serological Examinationmentioning

confidence: 99%

“…PGR was inversely correlated with CAG (transparency of blood vessels with a demarcation line - atrophic border) and IM (whitish spots with or without depressed hyperemic lesions) (p<0.001) [ 57 ]. PGR is closely correlated with histological CAG, and PGR<3.0 is considered an optimal value for the diagnosis of CAG with high sensitivity (71%), specificity (86%) and PPV (85%) [ 11 ]. A significant correlation was found between CAG, determined endoscopically and histologically, and the sensitivity and specificity of the endoscopic diagnosis were 65.9% and 58.0% for the gastric antrum, 71.3% and 53.7% for the gastric body, respectively [ 55 ].…”

Section: Comparison Of Endoscopic/histological and Serological Examinmentioning

confidence: 99%

“…Simultaneously with the increase of the severity of the atrophy of the mucous glands in the antrum and/or the gastric body, the PG-I and PG-II levels change accordingly and result in a decrease of the PG-I / PG-II (PGR) ratio. Although various values have been suggested, PG-I≤70 ng/ml and PGR≤3 have been widely accepted for CAG or GC prediction [ 8 , 9 , 11 , 14 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Chronic atrophic gastritis: an update on diagnosis

Botezatu

Bodrug

2020

Medicine and Pharmacy Reports

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Background and aim. Atrophic gastritis is a precancerous gastric lesion, therefore its early detection is a priority in preventing gastric cancer. The aim of the present paper is to develop a narrative synthesis of the present knowledge on diagnostic methods of chronic atrophic gastritis. Methods. A literature search was carried out on main databases: PubMed, Hinari, SpringerLink and Scopus (Elsevier) for the period 2000-2020. The searched keywords were: chronic atrophic gastritis, intestinal metaplasia and dysplasia + diagnosis. Inclusion criteria were focused on the articles about the invasive and non-invasive diagnosis of chronic atrophic gastritis and of precancerous gastric lesions, intestinal metaplasia and dysplasia; exclusion criteria were articles published before 2000 and those that did not include the proposed theme. Results. The search returned 575 papers addressing the topic of precancerous lesions. From these, 60 articles were qualified representative for the materials published on the topic of this synthesis article, being those that met the inclusion criteria. The data emphasize the need to use upper digestive endoscopy with biopsies for the diagnosis of chronic atrophic gastritis. However serological diagnosis is available as alternative mainly recommended in follow up. Conclusions. There are two main methodological approaches for the evaluation of chronic atrophic gastritis as a precancerous gastric lesions: invasive examination, which requires histological analysis of biopsy samples taken during upper digestive endoscopy, being the "gold standard" for diagnosis, and non-invasive serological examination using markers of gastric function.

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“…Most of the synthetic PG is released into the gastric cavity, and only about 1% enter the blood circulation 9 . In ideal state, serum PG can accurately reflect the state of gastric mucosal lesion 10 – 12 . G-17 is an important gastrointestinal peptide hormone and produced in the antrum by G cells, which is correlated with the position and degree of gastric mucosal atrophy.…”

Section: Introductionmentioning

confidence: 99%

A retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis

Liu

Tian

Hui

et al. 2021

Sci Rep

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Based on the antibody typing classification, Helicobacter pylori infection can be divided into type I H. pylori infection and type II H. pylori infection. To observe the effects of different H. pylori infection types on the distribution of histopathological characteristics and the levels of three items of serum gastric function (PG I, PG II, G-17). 1175 cases from October 2018 to February 2020 were collected with ratio 1:2. All patients were performed with 14C-Urea breath test (14C-UBT), H. pylori antibody typing classification, three items of serum gastric function detection, painless gastroscopy, pathological examination, etc. According to H. pylori antibody typing classification, patients were divided into three groups: type I H. pylori infection group, type II H. pylori infection group and control group. Significant difference existed among type I H. pylori infection group, type II H. pylori infection group and control group in inflammation and activity (χ2 = 165.43, 354.88, P all < 0.01). The proportion of three groups in OLGA staging had statistic difference (χ2 = 67.99, P all < 0.01); Compared with type II H. pylori infection group and control group, the level of pepsinogen I, pepsinogen II, gastrin17 in type I H. pylori infection group increased, and PG I/PG II ratio (PG I/PG II ratio, PGR) decreased, which was statistically significant (χ2 = 35.08, 166.24, 134.21, 141.19; P all < 0.01). Type I H. pylori infection worsened the severity of gastric mucosal inflammation and activity. H. pylori infection was prone to induce atrophy of gastric mucosa, while type I H. pylori infection played a key role in promoting the progress of atrophic gastritis and affected the level of serum gastric function. The study indicated that the eradication of H. pylori should be treated individually.

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Low PG I/II ratio as a marker of atrophic gastritis

Cited by 11 publications

References 26 publications

The Efficacy of Washed Microbiota Transplantation on Helicobacter pylori Eradication: A Pilot Study

The Efficacy of Washed Microbiota Transplantation on Helicobacter pylori Eradication: A Pilot Study

Chronic atrophic gastritis: an update on diagnosis

A retrospective study assessing the acceleration effect of type I Helicobacter pylori infection on the progress of atrophic gastritis

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