Effects of EPA and lipoic acid supplementation on circulating FGF21 and the fatty acid profile in overweight/obese women following a hypocaloric diet

Escoté, Xavier; Félix‐Soriano, Elisa; Gayoso, Lucía; Huerta, Ana; Alvarado, María Antonella; Ansorena, Diana; Astiasarán, Icíar; Martínéz, J. Alfredo; Moreno-Aliaga, María J.

doi:10.1039/c8fo00355f

Cited by 19 publications

(15 citation statements)

References 37 publications

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“…According to the survey 35 that was commissioned by the Council for Responsible Nutrition and conducted by Ipsos Public Affairs, nearly 9 in 10 (87%) adults in the United States had confidence in the safety, quality, and effectiveness of dietary supplements overall and 76% of them perceived the dietary supplement industry as trustworthy. This public opinion is not unexpected as postmarket reporting of 28 Fayh et al, 29 Swanson et al, 30 Escote et al, 31 and Abe et al 32 ADHD, attention deficit hyperactivity disorder; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; omega-3, omega-3 fatty acids.…”

Section: Discussionmentioning

confidence: 90%

“…26,27 In accordance with scientific research were also health claims that underlined that omega-3 support brain function and mental health, eye function, skin health, and have the immunoprotective effect. [28][29][30][31] Nevertheless these statements were proved in clinical studies, but according to FDA they are not conclusive. The statement that omega-3 reduce the risk of cancer can be considered as misgiven.…”

Section: Discussionmentioning

confidence: 99%

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Internet Marketing of Cardioprotective Dietary Supplements

Bjelica

Aleksić

Goločorbin-Kon

et al. 2020

The Journal of Alternative and Complementary Medicine

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Objectives: Considering high prevalence of use of dietary supplements and their easy access on the internet, the aim of this research was to examine and assess the prevalence of the internet marketing of heart-protective supplements as the most popular supplements of today, and to investigate the quality and quantity of information that are available to consumers on the sale websites. Design: Three major search engines (Google, Yahoo, and Bing) and keywords ''cardiovascular supportive supplements online buy'' were used to identify websites that sell cardioprotective dietary supplements. Content of first 50 listed websites in each engine was evaluated for its compliance with regulatory acts while information about supplements' efficacy and safety was compared with the results of the latest scientific research. Results: Of a total of 150 listed websites, 89 selling supplements for the specific indication underwent further analysis. The most commonly registered cardioprotective dietary supplements on the internet were supplements based on omega-3 fatty acids (omega-3) (57 websites, 64.05%). Related to the websites selling omega-3 supplements, risk reduction claims were presented at 23 (40.35%), whereas structure or function claims were present at 50 (87.72%) analyzed websites, but followed with Food and Drug Administration disclaimer only on 68.00% of them. Information about adverse effects were rarely pointed out (1 website, 1.75%) unlike warnings, which were significantly more available to consumers (38, 66.67%). Conclusions: According to obtained results, most of the analyzed websites that sell omega-3 supplements did not contain all important medical information required by Dietary Supplement Health and Education Act. Since use of internet marketing is in expansion and since consumers have no access to relevant medical information about dietary supplements on the selling websites, there is a clear need for better quality control of websites and greater public awareness of these widely used products.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Internet Marketing of Cardioprotective Dietary Supplements

Bjelica

Aleksić

Goločorbin-Kon

et al. 2020

The Journal of Alternative and Complementary Medicine

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show abstract

“…It seems that these two FGFs overlap in the body metabolism function [8]. Although one study showed the increasing effect of eicosapentaenoic acid (EPA) on serum FGF21 [11], the effect of other nutrients on FGFs is not clear.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effect of oral taurine supplementation on fasting levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in obese women on a weight-loss diet: a study protocol for a double-blind, randomized controlled trial

Haidari

Asadi

Mohammadi-Asl

et al. 2019

Trials

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Background Taurine (Tau) is involved in many biochemical functions such as regulation of glucose and lipid metabolism, enhancement of energy expenditure, anti-inflammatory effects and appetite control. The most important effect of Tau in obesity is its direct effect on adipose tissue. Some evidence has shown an impaired FGF (fibroblast growth factor) 19 and 21 biosyntheses in obesity. Besides the effects of eicosapentaenoic acid on serum FGF concentrations, the effect of other nutrients on FGFs is not clear. Since obesity as an important health problem is rising around the world and on the other side, Tau biosynthesis is reduced by adipose-tissue-derived factors in obesity, the effects of Tau and a weight-loss diet on obesity need to be investigated further. Methods We will conduct an 8-week. double-blind, parallel-group, randomized controlled clinical trial to investigate the effect of Tau supplementation on fasting serum levels of FGFs, β-Klotho co-receptor, some biochemical indices and body composition in 50 obese women aged between 18 and 49 years on a weight-loss diet. Discussion We will determine the other advantages of a weight-loss diet on new metabolic risk factors. Since Tau may regulate adipose-tissue-derived factors and a weight-loss diet can promote the useful effects of Tau supplementation; for the first time, the effects of a weight-loss diet along with Tau supplementation on these variables will be assessed. Trial registration Iran Clinical Trials Registry, ID: IRCT20131125015542N2 . Registered on 24 November 2018. Electronic supplementary material The online version of this article (10.1186/s13063-019-3421-5) contains supplementary material, which is available to authorized users.

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“…It seems that these two FGFs overlap in the body metabolism function (8). Although a study showed the increasing effect of eicosapentaenoic acid (EPA) on serum FGF21 (11), the effect of other nutrients on FGFs is not clear.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effect of oral taurine supplementation on levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in obese women on a weight-loss diet: a study protocol for a double-blind randomized controlled trial

Haidari

Asadi

Mohammadi-Asl

et al. 2019

Preprint

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Background: according to studies, the function of FGFs are disturbed in obesity. So that, serum level of FGFs are correlated with insulin resistance and obesity. Besides the effects of eicosapentaenoic acid on serum FGF21 concentrations, the effect of other nutrients on FGFs is not clear. Since obesity as an important health problem is rising in the world and on the other side, taurine (Tau) biosynthesis is reduced by adipose tissue-derived factors in obesity, the effects of Tau and a weight loss diet on obesity need to be investigated further. Methods: We will conduct a 2 month’s double-blind, parallel-group, randomized controlled clinical trial to investigate the effect of Tau supplementation on serum levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in obese women on a weight-loss diet. Discussion: we will determine the other advantages of a weight loss diet on metabolic risk factors. Moreover, for the first time, the effects of a weight loss diet along with Tau supplementation on these variables will be assessed.

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Effects of EPA and lipoic acid supplementation on circulating FGF21 and the fatty acid profile in overweight/obese women following a hypocaloric diet

Abstract: EPA and LIP supplementation regulate the serum fatty acid profile. EPA supplementation also modulates the FGF21 level.

Cited by 19 publications

References 37 publications

Internet Marketing of Cardioprotective Dietary Supplements

Internet Marketing of Cardioprotective Dietary Supplements

Evaluation of the effect of oral taurine supplementation on fasting levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in obese women on a weight-loss diet: a study protocol for a double-blind, randomized controlled trial

Evaluation of the effect of oral taurine supplementation on levels of fibroblast growth factors, β-Klotho co-receptor, some biochemical indices and body composition in obese women on a weight-loss diet: a study protocol for a double-blind randomized controlled trial

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