Hepatitis C coinfection adversely affects the life expectancy of people living with HIV in northwestern Poland

Leszczyszyn-Pynka, Magdalena; Ciejak, Piotr; Maciejewska, Katarzyna; Witak-Jȩdra, Magdalena; Karasińska-Cieślak, Malwina; Karpinska, E.; Wawrzynowicz‐Syczewska, Marta; Parczewski, Miłosz

doi:10.5114/aoms.2016.58744

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…The data on life expectancy of people living with HIV in comparison with clinical characteristics in Polish population are limited, with only reports from Northern part of Poland comparing survival probability among patients with coinfection HIV/HCV [ 21 ]. Only few studies associated survival with HLA-B*5701 variant.…”

Section: Discussionmentioning

confidence: 99%

Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV

et al. 2021

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Background The life expectancy of people living with HIV (PLWH) remains shorter than that of the general population, despite significant improvement in the recent years. Mortality in HIV-infected individuals may be associated with a higher viral load at of diagnosis, a lower CD4 count, or clinical variables such as sex or route of transmission. This article investigated the role of the HLA-B*5701 varian on mortality among PLWH. Methods Material for the analysis consist of the data of 2,393 patients for whom the HLA-B*57 variant was known. Those patients were followed under the care of the Infectious Diseases Hospital in Warsaw (n = 1555) and the Clinic of Acquired Immunodeficiency of the Pomeranian Medical University in Szczecin (n = 838). Factors such as age, gender, date of HIV diagnosis, route of transmission, date of death, baseline HIV viral load and baseline CD4 counts, were collected, and end-point cross-sectional analyses were marked at 60, 120, 180 and 240 month of observation. Results HLA-B*5701 allele was found in 133 (5.5%) analyzed cases. Median age was notably higher for HLA-B*5701 positive patients [32.7 (28.3–41.3) vs. 31.6 (26.8–38.3)years p = 0.02]. HLA-B*5701 was associated with lower baseline viral load [4.21 (3.5–4.8) vs. 4.79 (4.2–5.3)log copies/ml p<0.001] and higher CD4count [448 (294.5–662) vs. 352 (176–514) cells/μl p<0.001]. There were no association between HLA-B*5701 and survival for any given end-point. Higher mortality was associated to male gender, intravenous drug users, lower CD4 count at baseline and higher baseline viral load. Conclusions In our study, the presence of HLA-B*5701 allel was not associated with mortality rate of HIV infected patients, irrespective of being associated with both higher baseline CD4 + cell count and lower baseline HIV viral load.

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Section: Discussionmentioning

confidence: 99%

Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV

et al. 2021

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“…Finally, it should be stressed that G1a, present in 40.2% of the samples and including 46.7% of the AHC cases, has only been identified infrequently in Poland. More particularly, G1a has been reported in only 2.5% of the HCV mono-infections and in 17.8% among the HIV/HCV G1 infected cases 20,44 , and was virtually absent in a former dataset focusing on the global epidemiology of HCV genotype distribution, where only G1b infections were observed in the country. In Poland, G1a cases were previously observed among young individuals, however not linked to IDU transmission, in contrast to what has been reported for other regions.…”

Section: A C C E P T E Dmentioning

confidence: 91%

“…A stable increase in the number of new HIV diagnoses per year is observed across the country, with >22.000 cases diagnosed as of December 2017 19 . In the group of HIV/HCV co-infected patients, a decrease of 17.3 years in life expectancy is reported as well as a low likelihood of survival beyond the age of 65, associated with an increased risk of cardiovascular diseases, diabetes, neurocognitive performance and kidney disease, compared to those that are HCV mono-infected 20 . Although availability of DAA therapies has recently increased, access to treatment is not universal yet and is still prioritized for patients with advanced liver fibrosis, at least in Poland.…”

Section: A C C E P T E Dmentioning

confidence: 99%

Transmission Networks of HCV Genotype 1a Enriched With Pre-existing Polymorphism Q80K Among HIV-Infected Patients With Acute Hepatitis C in Poland

Parczewski

Cielniak

Kordek

et al. 2018

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…In Poland the percentage of co-infection might reach up to 71% of HIV positive persons and was shown to reduce life expectancy by 17.3 years [19,20]. The HC EP09 and BINECO studies showed that HCV/HIV co-infected patients had HCV RNA found in the semen more frequently than those without HIV infection (37.8% vs. 18.4%) [21].…”

Section: Discussionmentioning

confidence: 99%

The characteristics of HIV serodiscordant couples consulted at the HIV Out-Patient Clinic in Warsaw

Grzeszczuk¹,

Wróblewska²,

Firląg-Burkacka³

et al. 2017

HIV & AIDS Review

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Introduction: Human immunodeficiency virus (HIV) is predominantly transmitted through unprotected sexual intercourse. Condom use in long-term relations is uncertain, thus antiretroviral treatment can be the most efficient method of preventing HIV transmission. The objective of this study was to analyze epidemiological characteristics of HIV serodiscordant couples coming to consecutive visits. Material and methods:Data on demographics, HIV viral load, hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infections of HIV positive individuals (index patients) and data on sexual behavior, condom use in sexual relations were obtained from medical files.Results: There were 52 couples investigated: 16 (31%) homosexual and 36 (69%) heterosexual ones. In general, 47 (90%) HIV positive patients were on combination antiretroviral therapy (cART) and 42 (89%) had HIV RNA below 50 copies/ml at last measurement. During one year of observation, 18 (35%) patients had detectable HIV RNA. Out of index patients, 18 (35%) were anti-HCV positive, 1 (2%) was HBSAg positive and 4 (7.7%) were VDRL positive. Twenty (38%) persons admitted to have unprotected sexual contacts, 6 (29%) homosexual men and 15 (71%) heterosexual persons. Only 29 (56%) HIV negative partners were tested regularly for HIV. Ten (19%) of HIV positive patients already had children. There were five pregnancies during the time of the study. Four couples declared a desire to have children. Only 3 couples considered assisted reproduction. Conclusions:Unprotected sex occurs often among serodiscordant couples observed. Thus regular cART should be emphasized. Frequent co-infections (HCV and syphilis) among index patients prove that it is necessary to test HIV negative partners for these infections. The observation confirms purposefulness of couple counseling about safe conception.

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Hepatitis C coinfection adversely affects the life expectancy of people living with HIV in northwestern Poland

Cited by 7 publications

References 22 publications

Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV

Influence of HLA-B*5701 on 20 year survival rate among patients living with HIV

Transmission Networks of HCV Genotype 1a Enriched With Pre-existing Polymorphism Q80K Among HIV-Infected Patients With Acute Hepatitis C in Poland

The characteristics of HIV serodiscordant couples consulted at the HIV Out-Patient Clinic in Warsaw

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