Juvenile Osteochondritis Dissecans: Cartilage T2 Mapping of Stable Medial Femoral Condyle Lesions

Nguyen, Jie C.; Liu, Fang; Blankenbaker, Donna G.; Woo, Kaitlin M.; Kijowski, Richard

doi:10.1148/radiol.2018171995

Cited by 22 publications

(20 citation statements)

References 26 publications

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“…Studies have shown that the T2 value of the nucleus pulposus and fibrous rings of the intervertebral disc is significantly related to the water content and weakly related to the proteoglycan content 16 . The alignment and content of collagen fibers and water content in CEP are the main determinants of the T2 value 20,40 . T2 mapping imaging technology can reflect the tissue macromolecular environment and changes in biochemical components, including water, proteoglycans, and collagen by measuring the T2 relaxation time 36 .…”

Section: Role Of Cartilage Endplates In the Degeneration Of Intervertmentioning

confidence: 99%

Significant Association between the T2 Values of Vertebral Cartilage Endplates and Pfirrmann Grading

Cao

Guo²,

Wan

2020

Orthopaedic Surgery

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Objective The T2 value of lumbar cartilage endplates was measured using the T2 mapping imaging technique, aiming to explore the correlation between the T2 value and Pfirrmann grading of intervertebral discs. Methods A total of 130 patients with lumbar spine MR examination due to persistent low back pain were enrolled, including 71 men and 59 women (age: 21–63 years). Lumbar Modic changes and Schmorl nodules were recognized by conventional T1WI and T2WI images in 49 patients, and these patients were excluded from the study. A total of 81 patients were enrolled in this study, including 45 men (45.16 ± 12.20 years) and 36 women (43.33 ± 11.27 years). Pfirrmann (Pm) grading of each lumbar disc was performed based on conventional T2WI median sagittal images and the position of cartilage endplates (CEP) was determined by IDEAL‐SPGR images. Meanwhile, the T2 mapping technique was used to obtain T2 values of cartilage endplates. The T2 values of CEP corresponding to different Pm grade discs were compared, and the correlation between the T2 value and the Pm grade of intervertebral discs was analyzed. Results The T2 values of cephalic and caudal CEP of L1–2 in Pm grades I–II, Pm grades III, and Pm grades IV–V were 61.96 ± 5.89 ms, 54.45 ± 3.29 ms, 42.47 ± 3.69 ms and 64.35 ± 5.93 ms, 55.28 ± 3.97 ms, 44.75 ± 2.12 ms, respectively. For cephalic and caudal CEP of L2–3, the T2 values in Pm grades I–II, Pm grades III, and Pm grades IV–V were 62.96 ± 6.93 ms, 55.19 ± 4.02 ms, 48.67 ± 4.56 ms and 65.51 ± 6.49 ms, 57.16 ± 5.55 ms, 52.05 ± 4.20 ms, respectively. The T2 values of cephalic and caudal CEP from L3–4 to L5–S1 in Pm grades I–II, Pm grades III, and Pm grades IV–V were (63.72 ± 5.76 ms, 53.96 ± 6.52 ms, 48.05 ± 5.00 ms), (65.46 ± 6.37 ms, 55.70 ± 7.50 ms, 48.10 ± 3.27 ms); (66.34 ± 7.68 ms, 56.76 ± 9.48 ms, 47.80 ± 4.33 ms), (64.44 ± 4.65 ms, 59.30 ± 8.80 ms, 47.30 ± 5.78 ms), (65.32 ± 5.11 ms, 55.33 ± 6.65 ms, 48.18 ± 5.37 ms), and (63.47 ± 4.92 ms, 50.32 ± 8.86 ms, 44.77 ± 4.69 ms), respectively. There were significant differences in T2 values of cartilage endplates between the Pm grades I–II, III, and IV–V of intervertebral discs (P = 0.000). T2 values corresponding to Pm I–II grades were higher than those in Pm III grade, while T2 values in Pm grades IV–V were lowest. The T2 value of the L4–5, L5–S1 segment endplates was highly correlated with the Pm grades (r = −0.711, −0.721, −0.796, −0.745; P = 0.000) and that of L1–2, L2–3 endplates were moderately correlated (r = −0.542, −0.562, −0.637, −0.612; P = 0.000). Conclusion The T2 values of cartilage endplates revealed varying degrees of degeneration of intervertebral discs, and more severe degeneration corresponded to lower T2 values. Measurement of changes in the T2 value through cartilage endplates can be useful for the diagnosis of early intervertebral disc degeneration and the prevention of disc degeneration.

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Section: Role Of Cartilage Endplates In the Degeneration Of Intervertmentioning

confidence: 99%

Significant Association between the T2 Values of Vertebral Cartilage Endplates and Pfirrmann Grading

Cao

Guo²,

Wan

2020

Orthopaedic Surgery

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“…T 2 mapping has been introduced into clinical practice for various organs and tissues, including brain, heart, and cartilage . In neuroradiology, a microstructural change, such as neuronal loss or demyelination, results in increased free water and thus longer T 2 relaxation times and greater signal intensity on T 2 ‐weighted MRI images .…”

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confidence: 99%

“…T 2 mapping has been introduced into clinical practice for various organs and tissues, including brain, [6][7][8] heart, 4,9 and cartilage. 5,[10][11][12] In neuroradiology, a microstructural change, such as neuronal loss or demyelination, results in increased free water and thus longer T 2 relaxation times and greater signal intensity on T 2 -weighted MRI images. 13 Furthermore, T 2 mapping is used to assess cartilage damage in musculoskeletal imaging [10][11][12] and to evaluate cardiac edema and fibrosis.…”

mentioning

confidence: 99%

“…5,[10][11][12] In neuroradiology, a microstructural change, such as neuronal loss or demyelination, results in increased free water and thus longer T 2 relaxation times and greater signal intensity on T 2 -weighted MRI images. 13 Furthermore, T 2 mapping is used to assess cartilage damage in musculoskeletal imaging [10][11][12] and to evaluate cardiac edema and fibrosis. 9 T 2 mapping in the abdomen has proven more difficult because of movement of the abdominal organs with breathing.…”

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confidence: 99%

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Patient respiratory‐triggered quantitative T₂ mapping in the pancreas

Violi

Hilbert

Bastiaansen

et al. 2019

Magnetic Resonance Imaging

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Background Long acquisition times and motion sensitivity limit T2 mapping in the abdomen. Accelerated mapping at 3 T may allow for quantitative assessment of diffuse pancreatic disease in patients during free‐breathing. Purpose To test the feasibility of respiratory‐triggered quantitative T2 analysis in the pancreas and correlate T2‐values with age, body mass index, pancreatic location, main pancreatic duct dilatation, and underlying pathology. Study Type Retrospective single‐center pilot study. Population Eighty‐eight adults. Field Strength/Sequence Ten‐fold accelerated multiecho‐spin‐echo 3 T MRI sequence to quantify T2 at 3 T. Assessment Two radiologists independently delineated three regions of interest inside the pancreatic head, body, and tail for each acquisition. Means and standard deviations for T2 values in these regions were determined. T2‐value variation with demographic data, intraparenchymal location, pancreatic duct dilation, and underlying pancreatic disease was assessed. Statistical Tests Interreader reliability was determined by calculating the interclass coefficient (ICCs). T2 values were compared for different pancreatic locations by analysis of variance (ANOVA). Interpatient associations between T2 values and demographical, clinical, and radiological data were calculated (ANOVA). Results The accelerated T2 mapping sequence was successfully performed in all participants (mean acquisition time, 2:48 ± 0:43 min). Low T2 value variability was observed across all patients (intersubject) (head: 60.2 ± 8.3 msec, body: 63.9 ± 11.5 msec, tail: 66.8 ± 16.4 msec). Interreader agreement was good (ICC, 0.82, 95% confidence interval: 0.77–0.86). T2‐values differed significantly depending on age (P < 0.001), location (P < 0.001), main pancreatic duct dilatation (P < 0.001), and diffuse pancreatic disease (P < 0.03). Data Conclusion The feasibility of accelerated T2 mapping at 3 T in moving abdominal organs was demonstrated in the pancreas, since T2 values were stable and reproducible. In the pancreatic parenchyma, T2‐values were significantly dependent on demographic and clinical parameters. Level of Evidence: 4 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;50:410–416.

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“…T2 mapping is able to detect changes in the chondral collagen matrix and in the overall water content of the cartilage 9 . T2 mapping has been established and validated for detection and quantification of these early degenerative changes in various joints, including the knee, metacarpophalangeal joints, wrist, and ankle 7,[14][15][16] . Higher T2 values indicate damage to the three-dimensional collagen network and an increase in the water content [15][16][17] .…”

mentioning

confidence: 99%

3-T T2 mapping magnetic resonance imaging for biochemical assessment of normal and damaged glenoid cartilage: a prospective arthroscopy-controlled study

Wuennemann

Kintzelé

Braun

et al. 2020

Sci Rep

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This study evaluated the ability of T2 mapping to assess the glenoid cartilage using arthroscopy as the gold standard. Eighteen consecutive patients (mean age: 52.4 ± 14.72 years, including 12 men) with shoulder pain underwent T2 mapping at 3-T with subsequent shoulder arthroscopy. With correlation to cartilage-sensitive morphologic sequences regions-of-interest were placed in the corresponding T2 maps both in normal-appearing cartilage and focal cartilage lesions using a quadrant-wise approach. Inter-reader and intra-reader correlation coefficients (ICCs) between two independent radiologists as well as cutoff values with their sensitivities/specificities for the detection of cartilage damage were calculated. The mean T2 value for healthy cartilage was 23.0 ± 3 ms with significantly higher values in the superior quadrants compared to the inferior quadrants (p < 0.0001). In 5 patients with focal cartilage damage significantly higher T2 values of 44.7 ± 3.7 ms (P < 0.01) were observed. The maximum T2 value in normal cartilage (27.3 ms) was lower than the minimum value in damaged cartilage (40.8 ms) resulting in perfect sensitivities/specificities of 100% (95% confidence-interval 47.8-100.0) for all cutoff values between 27.3-40.8 ms. ICCs ranged between 0.63 and 0.99. In conclusion, T2 mapping can evaluate biochemical cartilage integrity and discriminates arthroscopyproven healthy and damaged glenoid cartilage with high diagnostic performance. Osteoarthritis (OA) is a degenerative condition affecting the articulating facet joints. It is the most commonly encountered orthopaedic disorder and a leading cause of morbidity in elderly patients 1-3. Although OA predominantly affects the weight-bearing joints, glenoid OA is a well-known cause of shoulder disability with an increasing incidence and prevalence and ultimately leads to endoprosthetic joint replacement 4, 5. Cartilage defects are an important risk factor for development of OA 6, 7. Therefore, timely diagnosis of early and potentially reversible disruption of the chondral architecture is desirable to delay the onset and progression of OA. Magnetic resonance imaging (MRI) is the non-invasive gold standard for morphological evaluation of the articular cartilage 8. However, early degenerative changes in the cartilage, such as loss of glycosaminoglycans

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Juvenile Osteochondritis Dissecans: Cartilage T2 Mapping of Stable Medial Femoral Condyle Lesions

Cited by 22 publications

References 26 publications

Significant Association between the T2 Values of Vertebral Cartilage Endplates and Pfirrmann Grading

Significant Association between the T2 Values of Vertebral Cartilage Endplates and Pfirrmann Grading

Patient respiratory‐triggered quantitative T₂ mapping in the pancreas

3-T T2 mapping magnetic resonance imaging for biochemical assessment of normal and damaged glenoid cartilage: a prospective arthroscopy-controlled study

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Juvenile Osteochondritis Dissecans: Cartilage T2 Mapping of Stable Medial Femoral Condyle Lesions

Cited by 22 publications

References 26 publications

Significant Association between the T2 Values of Vertebral Cartilage Endplates and Pfirrmann Grading

Significant Association between the T2 Values of Vertebral Cartilage Endplates and Pfirrmann Grading

Patient respiratory‐triggered quantitative T2 mapping in the pancreas

3-T T2 mapping magnetic resonance imaging for biochemical assessment of normal and damaged glenoid cartilage: a prospective arthroscopy-controlled study

Contact Info

Product

Resources

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Patient respiratory‐triggered quantitative T₂ mapping in the pancreas