Diagnostic Performance of Shear Wave Elastography in Patients With Autoimmune Liver Disease

Li, Changtian; Dhyani, Manish; Bhan, Atul K.; Grajo, Joseph R.; Pratt, Daniel S.; Gee, Michael S.; Samir, Anthony E.

doi:10.1002/jum.14668

Cited by 6 publications

(3 citation statements)

References 41 publications

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“…130,137 The AUROCs for 2D-SWE in diagnosing ≥F2, ≥F3, and F4 were 0.85, 0.85, and 0.86, respectively. 138 Other studies reported similar AUROCs ranging from 0.781 to 0.84, 139,140 showing higher predictive efficacy compared to APRI and FIB-4 (AUROC, 0.84 vs. 0.57 vs. 0.63). 140 A single-center study in South Korea on point SWE which generates shear wave in one area revealed an AUROC of 0.8, similar to the results of studies from other countries that showed point SWE outperforming APRI and FIB-4.…”

Section: Imaging Modalitiesmentioning

confidence: 88%

KASL clinical practice guidelines for management of autoimmune hepatitis 2022

2023

Clin Mol Hepatol

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Section: Imaging Modalitiesmentioning

confidence: 88%

KASL clinical practice guidelines for management of autoimmune hepatitis 2022

2023

Clin Mol Hepatol

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“…[ 9 , 14 ] The use of elastic techniques in AIH is also increasing, and in this study, we also found a positive correlation between LS measurements and liver fibrosis grades in previous studies, which is consistent with many other studies. [ 12 , 15 ] Maciej used ultrasound elastography (transient elastography, TE and two-dimensional shear wave elasticity) to measure liver and spleen stiffness to predict the incidence of AIH cirrhosis. When the cutoff value of liver and spleen stiffness was set at 16.1 kPa and 29.8 kPa, respectively, the AUC could reach 0.93 to 0.95.…”

Section: Discussionmentioning

confidence: 99%

A novel model predicted liver cirrhosis constructed by ultrasound and serological in autoimmune liver hepatitis

Feng,

Tu,

Chen

2023

Medicine

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To establish a noninvasive model based on two-dimensional shear wave elasticity (2D-SWE) technology, ultrasound feature and serological indicators to predict cirrhosis in autoimmune hepatitis (AIH) and verified. Patients with AIH confirmed by liver biopsy with liver ultrasound and serological examination were collected from January 2019 to May 2022. Patients were divided into cirrhosis and non-cirrhosis groups. Basic indexes, ultrasound indexes and serological indexes were collected. Multivariable logistic regression used for screening independent risk factors predicting cirrhosis, construct the AIH cirrhosis prediction model, named autoimmune hepatitis cirrhosis (AIHC). Determine best cutoff score according to the Youden index, verified the model’s predictive efficacy. One hundred forty-six patients were collected. The following indicators were independent risk factors for predicting cirrhosis: LS (OR: 1.416, P = .015), splenomegaly (OR: 10.446, P = .006), complement C4 (OR: 0.020, P = .009). The best cutoff score was 65, with a sensitivity 88.9% and specificity 75.6%; the area under curve was 0.901, AIHC possessed a higher net reclassification index (NRI) and integrated discrimination improvement compared with other indexes, and AIHC had the best clinical decision curve. The AIHC constructed in this study has better predictive efficacy than other noninvasive indexes, and we visualized the model for easy application, which was worth further promotion in clinical practice.

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“…There are two recent studies of autoimmune liver disease[ 59 , 60 ]. Because of the low prevalence of this disease, these studies included patients with autoimmune hepatitis, primary biliary cholangitis, primary sclerosing cholangitis, and overlap syndrome, all of which have different liver damage patterns[ 59 , 60 ]. For this reason, the AUROCs of autoimmune liver disease according to fibrosis stage were lower than those of chronic viral hepatitis[ 59 , 60 ].…”

Section: Role Of 2d-swe In Assessing Liver Fibrosismentioning

confidence: 99%

Role of two-dimensional shear wave elastography in chronic liver diseases: A narrative review

Jeong

Cho

Sohn

2018

WJG

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Liver biopsy is the gold standard for evaluating the degree of liver fibrosis in patients with chronic liver disease. However, due to the many limitations of liver biopsy, there has been much interest in the use of noninvasive techniques for this purpose. Among these techniques real-time two-dimensional shear wave elastography (2D-SWE) has the advantage of measuring tissue elasticity with the guidance of B-mode images. Recently, many studies have been conducted on the application of 2D-SWE in patients with various liver diseases, and their validity has been confirmed. Here, we briefly discuss the role of 2D-SWE in patients with chronic liver diseases, particularly aspects of the examination techniques and clinical applications.

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Diagnostic Performance of Shear Wave Elastography in Patients With Autoimmune Liver Disease

Abstract: Shear wave elastography is a novel noninvasive adjunct to liver biopsy in evaluation and staging of patients with ALD, showing the potential for serial evaluations of disease progression and treatment responses.

Cited by 6 publications

References 41 publications

KASL clinical practice guidelines for management of autoimmune hepatitis 2022

KASL clinical practice guidelines for management of autoimmune hepatitis 2022

A novel model predicted liver cirrhosis constructed by ultrasound and serological in autoimmune liver hepatitis

Role of two-dimensional shear wave elastography in chronic liver diseases: A narrative review

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