Influence of CA125, platelet count and neutrophil to lymphocyte ratio on the immune system of ovarian cancer patients

Baert, Thaïs; Camp, Joke Van; Vanbrabant, L; Busschaert, Pieter; Laenen, Annouschka; Han, Sileny N.; Nieuwenhuysen, Els Van; Vergote, Ignace; Coosemans, An

doi:10.1016/j.ygyno.2018.05.004

Cited by 53 publications

(45 citation statements)

References 44 publications

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“…This may be because allogeneic blood cells are exogenous substances that induce immune responses in recipients and inhibit systematic anti-tumor immune function [11,12]. Some laboratory-based inflammatory indicators related to inflammatory and immune responses, such as the NLR (neutrophil-to-lymphocyte ratio), LMR (lymphocyte-to-monocyte ratio) and SII (systemic immune inflammation index), have been shown to be associated with prognosis in ovarian cancer [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Impact of perioperative red blood cell transfusion on postoperative recovery and long-term outcome in patients undergoing surgery for ovarian cancer: A propensity score-matched analysis

Zhang¹,

Wu²,

Xu³

et al. 2020

Gynecologic Oncology

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Section: Introductionmentioning

confidence: 99%

Impact of perioperative red blood cell transfusion on postoperative recovery and long-term outcome in patients undergoing surgery for ovarian cancer: A propensity score-matched analysis

Zhang¹,

Wu²,

Xu³

et al. 2020

Gynecologic Oncology

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“…An increased NLR (≥4) has been suggested to serve as a marker for the host inflammatory response with increased neutrophils potentially serving as a source of VEGF, facilitating angiogenesis and tumor progression [23]. An increased NLR and low serum albumin have been previously shown to be prognostic predictors of poor survival in EOC [22,23,28]. Similarly, presence of liver parenchyma and bone metastases have previously been shown to be indicative of late stage metastatic disease in EOC patients [29,30], and thus may highlight more aggressive tumor biology.…”

Section: Discussionmentioning

confidence: 99%

Early disease progression and treatment discontinuation in patients with advanced ovarian cancer receiving immune checkpoint blockade

Boland

Zhou

Martin

et al. 2019

Gynecologic Oncology

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In ovarian cancer patients treated with immune checkpoint blockade, early discontinuation of therapy is common. • Symptomatic disease progression was common and accounted for early treatment discontinuation in the majority of patients. • Ovarian cancer patients with heavily pretreated, recurrent disease may not be suitable candidates for immunotherapy. • Pre-treatment clinical parameters can identify the patients at risk for early discontinuation and symptomatic progression.

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“…The cut-off of 6.0 was chosen based on its association with poor outcome according to previous studies. 15,16 The primary outcome was the result of the interval surgical intervention defined as optimal debulking (<1 cm residual disease). NACT was offered to patients with advanced stage ovarian carcinoma who therefore had a low likelihood of achieving optimal debulking in primary cytoreduction, or those with high perioperative risk profile.…”

Section: Materialsandmethodsmentioning

confidence: 99%

Neutrophil‐to‐lymphocyte ratio as a prognostic factor in advanced stage ovarian carcinoma treated with neoadjuvant chemotherapy

Salman

Sabah

Jakobson‐Setton

et al. 2019

Intl J Gynecology & Obste

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Objectives To evaluate the prognostic significance of neutrophil‐to‐lymphocyte ratio (NLR) upon diagnosis, and its impact on surgical outcome, among patients with advanced stage ovarian carcinoma treated with neoadjuvant chemotherapy (NACT). Methods A retrospective cohort study included all women with stage IIIC and IV ovarian carcinoma receiving NACT in Rabin Medical Center, Petah‐Tikva, Israel; January 1, 2005, to June 30, 2017. Demographics and treatment outcome were compared between patients with NLR at diagnosis ≥6.0 and those with NLR <6.0. Primary outcome was optimal debulking (<1 cm largest residual disease). Overall survival was compared between groups using Kaplan‐Meier survival analysis. Results Of 111 patients, 33 (29.7%) had NLR ≥6.0 at diagnosis, and 78 (70.3%) had NLR <6.0. No difference was found in rates of optimal debulking between the group with NLR ≥6.0 and that with NLR <6.0 (78.9% vs 84.7%, respectively, P=0.555). Using Kaplan‐Meier survival analysis, NLR ≥6.0 was associated with significantly worse overall survival (P<0.05). In a multivariate Cox proportional hazard model, elevated NLR was not statistically associated with poor overall survival (P=0.080). Conclusions In advanced stage ovarian carcinoma, NLR ≥6.0 at diagnosis did not predict surgical outcome, however it was a predictive factor for poor overall survival.

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Influence of CA125, platelet count and neutrophil to lymphocyte ratio on the immune system of ovarian cancer patients

Abstract: A correlation, at the time of diagnosis, of HGSOC between CA125, NLR and thrombocytes and an immunosuppressive cytokine-profile in serum is shown, and correlates with survival.

Cited by 53 publications

References 44 publications

Impact of perioperative red blood cell transfusion on postoperative recovery and long-term outcome in patients undergoing surgery for ovarian cancer: A propensity score-matched analysis

Impact of perioperative red blood cell transfusion on postoperative recovery and long-term outcome in patients undergoing surgery for ovarian cancer: A propensity score-matched analysis

Early disease progression and treatment discontinuation in patients with advanced ovarian cancer receiving immune checkpoint blockade

Neutrophil‐to‐lymphocyte ratio as a prognostic factor in advanced stage ovarian carcinoma treated with neoadjuvant chemotherapy

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