Translation regulation of mammalian selenoproteins

Vindry, Caroline; Ohlmann, Théophile; Chavatte, Laurent

doi:10.1016/j.bbagen.2018.05.010

Cited by 42 publications

(46 citation statements)

References 106 publications

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“…GPx3, along with GPx1, is ranked lowest in this hierarchy [47,48]. Hence their expression is very sensitive to decreasing Se levels and disappears rapidly in response to Se deficiency, due to nonsense-mediated mRNA decay (details of selenocysteine translational regulation are further reviewed in [22,49,50]).…”

Section: Gpx3 Regulationmentioning

confidence: 99%

Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer

Chang

Worley

Phaëton

et al. 2020

Cancers

138

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Mammalian cells possess a multifaceted antioxidant enzyme system, which includes superoxide dismutases, catalase, the peroxiredoxin/thioredoxin and the glutathione peroxidase systems. The dichotomous role of reactive oxygen species and antioxidant enzymes in tumorigenesis and cancer progression complicates the use of small molecule antioxidants, pro-oxidants, and targeting of antioxidant enzymes as therapeutic approaches for cancer treatment. It also highlights the need for additional studies to investigate the role and regulation of these antioxidant enzymes in cancer. The focus of this review is on glutathione peroxidase 3 (GPx3), a selenoprotein, and the only extracellular GPx of a family of oxidoreductases that catalyze the detoxification of hydro- and soluble lipid hydroperoxides by reduced glutathione. In addition to summarizing the biochemical function, regulation, and disease associations of GPx3, we specifically discuss the role and regulation of systemic and tumor cell expressed GPx3 in cancer. From this it is evident that GPx3 has a dichotomous role in different tumor types, acting as both a tumor suppressor and pro-survival protein. Further studies are needed to examine how loss or gain of GPx3 specifically affects oxidant scavenging and redox signaling in the extracellular tumor microenvironment, and how GPx3 might be targeted for therapeutic intervention.

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Section: Gpx3 Regulationmentioning

confidence: 99%

Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer

Chang

Worley

Phaëton

et al. 2020

Cancers

138

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“…The human genome codes for 25 selenoproteins in which the stop codon UGA specifically insert the selenocysteine. This amino acid is not charged as such on its dedicated tRNA but is instead synthesized onto a specific Se-Cys-tRNA [Ser]Se-Cys from the serine [62].…”

Section: Gastrointestinal Uptakementioning

confidence: 99%

“…The latter is further reduced to H 2 Se. The addition of phosphate to Selenide by the selenophosphate 2 synthetase produce a selenophosphate (H 2 SePO 3− ) [64], which can be used as a precursor for selenocysteine synthesis [62].…”

Section: Gastrointestinal Uptakementioning

confidence: 99%

Selenium Deficiency—From Soil to Thyroid Cancer

et al. 2020

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Selenium (Se) is an essential micronutrient present in human diet, entering in the composition of selenoproteins as selenocysteine (Se-Cys) amino acid. At the thyroid level, these proteins play an important role as antioxidant and in hormone metabolism. Selenoproteins are essential for the balance of redox homeostasis and antioxidant defense of mammalian organisms, while the corresponding imbalance is now recognized as the cause of many diseases including cancer. The food chain is the main source of Se in human body. Dietary intake is strongly correlated with Se content in soil and varies according to several factors such as geology and atmospheric input. Both Se deficiency and toxicity have been associated with adverse health effects. This review synthesizes recent data on the transfer of Se from soil to humans, Se U-shaped deficiency and toxicity uptake effects and particularly the impact of Se deficiency on thyroid cancer.

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“…O selênio é um oligoelemento com ampla gama de efeitos no organismo, especialmente na imunidade, além de ser essencial para a biologia redox em mamíferos e possuir propriedades anti-inflamatórias (Rayman, 2012;Maggini et al, 2018;Wang et al, 2018a;Wang et al, 2018b). Inúmeros estudos epidemiológicos puderam mostrar a associação existente entre baixos níveis de selênio no organismo e o aumento de desenvolvimento de patologias como cânceres, doenças neurodegenerativas, distúrbios cardiovasculares e doenças infecciosas (Papp, Holmgren, & Khanna, 2010;Rayman, 2012;Kurokawa & Berry, 2013;Hatfield, Tsuji, Carlson, & Gladyshev, 2014;Meplan & Hesketh, 2014;Sonet et al, 2016;Avery & Hoffmann, 2018;Vindry et al, 2018). A maioria de seus benefícios se dão pela sua incorporação na forma de selenocisteína (proteína semelhante a cisteína, acrescida de selênio Development, v. 9, n. 9, e192996714, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v9i9.6714 21 no lugar de enxofre) em selenoproteínas (grupo essencial de proteínas que possuem um resíduo da selenocisteína), as quais possuem funções celulares como antioxidante, sinalização celular e homeostase redox (Labunskyy, Hatfield, & Gladyshev, 2014).…”

Section: Selêniounclassified

Evidências de suporte nutricional em pacientes com diagnóstico da COVID-19

Ferreira

Donato

Melo

2020

RSD

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Em dezembro de 2019, Wuhan, capital de Hubei, província da China, se deparou com um surto semelhante à pneumonia, de causa desconhecida, com apresentações clínicas semelhantes a um quadro de infecção viral. Em um mês, amostras do trato respiratório inferior foram submetidas a uma análise de sequenciamento, caracterizando o quadro como decorrente de coronavírus, recebendo o nome de Síndrome Respiratória Aguda Grave Coronavírus 2 (SARS-CoV-2) ou COVID-19, como designado pela Organização Mundial da Saúde. Desde então, a doença tem alcançado países ao redor do mundo, os quais ainda buscam um tratamento eficaz para a doença. Tendo em vista que a integridade do sistema imunológico é crucial para recuperação e melhora do prognóstico dos pacientes acometidos pela infecção, a oferta adequada de nutrientes se faz indispensável para a manutenção deste, além de que, a inadequação do estado nutricional pode aumentar a predisposição a infecções secundárias, complicações hospitalares e as taxas de morbidade e mortalidade. Diante disso, o presente estudo corresponde a uma revisão de literatura publicada nos últimos 20 anos, compilando as principas evidências de que vitaminas e minerais podem atuar como potencializadores dos tratamentos propostos e auxiliar direta, ou indiretamente, a recuperação dos pacientes da COVID-19.

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Translation regulation of mammalian selenoproteins

Cited by 42 publications

References 106 publications

Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer

Extracellular Glutathione Peroxidase GPx3 and Its Role in Cancer

Selenium Deficiency—From Soil to Thyroid Cancer

Evidências de suporte nutricional em pacientes com diagnóstico da COVID-19

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