Cytopenia in adult brucellosis patients

Kaya, Şafak; Elaldı, Nazif; Deveci, Özcan; Eşkazan, Ahmet Emre; Bekçibaşı, Muhammed; Hoşoğlu, Salih

doi:10.4103/ijmr.ijmr_542_15

Cited by 16 publications

(14 citation statements)

References 25 publications

(29 reference statements)

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“…In China, a case of subdural empyema complicated by intracerebral abscess due to Brucella infection was effectively treated with antibiotic therapy (ceftriaxone, doxycycline, rifapentine) [ 108 ]. In line with this, several reports suggested the combination therapy of doxycycline and rifampicin for six weeks is enough to eradicate Brucella infection, as well as associated complications [ 46 , 109 , 110 , 111 ]. This combination of doxycycline and rifampicin has also been proven experimentally [ 112 ].…”

Section: Treatment Of Brucellosismentioning

confidence: 81%

An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies

2018

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Brucellosis is one of the most common contagious and communicable zoonotic diseases with high rates of morbidity and lifetime sterility. There has been a momentous increase over the recent years in intra/interspecific infection rates, due to poor management and limited resources, especially in developing countries. Abortion in the last trimester is a predominant sign, followed by reduced milk yield and high temperature in cattle, while in humans it is characterized by undulant fever, general malaise, and arthritis. While the clinical picture of brucellosis in humans and cattle is not clear and often misleading with the classical serological diagnosis, efforts have been made to overcome the limitations of current serological assays through the development of PCR-based diagnosis. Due to its complex nature, brucellosis remains a serious threat to public health and livestock in developing countries. In this review, we summarized the recent literature, significant advancements, and challenges in the treatment and vaccination against brucellosis, with a special focus on developing countries.

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Section: Treatment Of Brucellosismentioning

confidence: 81%

An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies

2018

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“…In about 30% of cases, there is focalization of the infection [9,16,17]. Hematological involvement with anemia and leukopenia, like our patient presented, is relatively common [18]. Although gastrointestinal complaints are common in infections by Brucella spp., documented specific ileum lesions caused by Brucella spp.…”

Section: Discussionmentioning

confidence: 47%

A Case of Brucellosis with Possible Ileal Involvement

Santos

Silva

Nejo

et al. 2019

GE Port J Gastroenterol

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Introduction: Brucellosis is a zoonotic disease that can involve different organs and tissues. Fever, fatigue, lymphadenopathy, hepatosplenomegaly, cytopenia, and arthritis are the usual modes of presentation. Gastrointestinal manifestations of human brucellosis are common but documented ileal involvement is extremely rare. Case Description: A 68-year-old female presented with a history of 10 days of intense temporal migraine, photophobia, and phonophobia with partial response to paracetamol. The patient referred night sweats, anorexia, and colicky abdominal pain after her meals for the past 4 months followed by diarrhea. She denied nausea, vomiting, hypersensitivity of the scalp, blurry vision, melena, or rectal bleeding. She denied travelling or contact with animals. Physical examination revealed fever (38.3 ° C) and splenomegaly. Laboratory workup revealed Hb 7.8 g/dL, leukopenia (3.47 × 10 9 /L), C-reactive protein 5.94 mg/dL, and erythrocyte sedimentation rate 23 mm/h. Abdominal ultrasound showed hepatic steatosis and mild ho-

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“…In developed countries, infection most often occurs via occupational exposure, such as inhalation of infectious aerosols in microbiology laboratories [ 6 ]. However, it can also be acquired through direct skin or mucosal contact with infected livestock [ 6 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Pancytopenia may occur in up to 2–14% of affected individuals [ 5 ]. There are no disease-specific findings to distinguish brucellosis-induced cytopenias from noninfectious etiologies, and therefore, brucellosis is frequently misdiagnosed as a primary hematologic disease or malignancy [ 7 ]. Fortunately, hematologic manifestations typically resolve with treatment of the underlying brucellosis.…”

Section: Discussionmentioning

confidence: 99%

“…Timely and accurate diagnosis of brucellosis is often challenging due to the prolonged incubation period and variable clinical picture [ 9 ]. Isolation of Brucella from blood cultures represents the gold standard diagnostic test, but often requires several weeks to yield results [ 1 , 7 , 8 ]. Serologic studies are only slightly less sensitive and specific than cultures and can be obtained within days [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Brucellosis Presenting with Febrile Pancytopenia: An Atypical Presentation of a Common Disease and Review of Brucellosis

Chang¹,

Beutler

Ulanja

et al. 2021

Case Reports in Infectious Diseases

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Brucellosis is a febrile zoonotic disease caused by one of several species of the Gram-negative coccobacillus Brucella. It is endemic to the Middle East, sub-Saharan Africa, and Central America. However, cases have also been reported in the United States. Infection is most commonly transmitted via unpasteurized dairy products or through occupational exposure to livestock. The clinical presentation is highly variable; symptoms may include fever, myalgias, night sweats, weight loss, nausea, and vomiting. Less common features include orchitis, osteomyelitis, and sacroiliitis. In addition, pregnant women who contract brucellosis face a markedly increased risk of miscarriage. A presumptive diagnosis is typically established through correlation of patient history and classic laboratory findings, which include transaminitis, anemia, and leukopenia with relative lymphocytosis. Definitive diagnosis can only be established through isolation of Brucella species from blood or tissues. Treatment involves a prolonged course of multiple antibiotics; six weeks of combination therapy with aminoglycoside or rifampin and tetracycline represents the most common regimen. Healthy individuals who develop brucellosis have a generally favorable prognosis, as the case fatality rate is less than 2%. Nevertheless, early detection and treatment are essential to reduce the risk of long-term sequelae that may result from chronic, indolent disease.

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Cytopenia in adult brucellosis patients

Cited by 16 publications

References 25 publications

An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies

An Overview of Brucellosis in Cattle and Humans, and its Serological and Molecular Diagnosis in Control Strategies

A Case of Brucellosis with Possible Ileal Involvement

Brucellosis Presenting with Febrile Pancytopenia: An Atypical Presentation of a Common Disease and Review of Brucellosis

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