Equivalence and non-inferiority trials are becoming more and more popular. Typically, they compare the effects of a treatment of interest with the current gold-standard treatment as the comparator. However, for this approach, the definition of equivalence or non-inferiority margins (NIM) is crucial, and no clear rules for their definition exist. We criticized the practice of these trials of being over-inflationary in favor of (erroneous) equivalence, and we outlined our critique with some study examples comparing psychodynamic treatments with current firstline treatments for mental disorders. Here we answer to a commentary of Leichsenring et al. to our paper. Although focusing on our commentary, these authors are less arguing against our conclusions, but they address issues of study conduct, and lack of appreciation of our examples. However, the crucial question is: What is the risk of erroneous equivalence conclusions that we want to accept as responsible clinicians and scientists? We conclude that the scientific community has to define better and clearer criteria for NIMs. We do not believe that it is ethically justifiable to recommend a treatment that is 10 or 20% less effective than the current gold standard interventions.Equivalence and non-inferiority trials typically compare the effects of a treatment of interest with the current gold-standard treatment as the comparator. For this approach, the definition of equivalence or non-inferiority margins (NIM) is crucial, as we had noted earlier (Rief and Hofmann, 2018). Leichsenring et al. (2018) opposed our arguments, based on other examples and their own trials advocating for psychodynamic treatments.First, we want to thank Leichsenring and colleagues for their thorough report and interest on our paper. The authors present an impressive variety of NIMs that have been used in prior publications, confirming our argument that there is no clear consensus for defining NIMs. We also accept their critique that we did not differentiate between non-inferiority and equivalence trials; our critique applies to both types and does not require this differentiation.The reasons for erroneous non-inferiority results of two treatments can be manifold. Poor study quality, insensitive ascertainment or statistical analyses procedures, poor implementation of (comparator) treatments are just a few examples, as outlined in our original commentary. Even if Leichsenring et al. do not appreciate our examples, they do not provide a convincing argument against these conclusions. We continue to encourage the scientific community to consider the pivotal question with regard to NIMs: What is the risk of erroneous equivalence conclusions that we want to accept as responsible clinicians and scientists in the era of the replicability crisis?We explicitly reject Leichsenring's notion that we misrepresented the results of the Steinert et al. (2017) study. Therefore, we present the original results in Fig. 1 here again. While the authors concluded that results indicate equality between two treatmen...