Methylphenidate-mediated motor control network enhancement in patients with traumatic brain injury

Abstract

Our findings suggest that residual functionality in patients with TBI may be enhanced by a single dose of methylphenidate.

Effects of Methylphenidate on Cognitive Function in Adults with Traumatic Brain Injury: A Meta-Analysis

“…With regards to the severity of TBIs, most of the studies reported moderate to severe injuries [14,16,19,21,22,23,25,26]. Others were mild to moderate [15,18], mild to severe [11,12,24,27], and mild [17]. Two studies did not mention about the severity index [13,20].…”

“…The pooled estimates with 95% CI were computed using inverse variance method with a random-effects model to account for the heterogeneity between studies. Crossover studies [11,15,16,23,26] were treated as paired groups, with the correlation coefficient between intervention and placebo set as 0.5. In studies where the outcomes were reported as the median and interquartile range [28], the sample mean and standard deviation were estimated based on previous literature [29].…”

Follow-up after 5.5 years of treatment with methylphenidate for mental fatigue and cognitive function after a mild traumatic brain injury

“…Other studies evaluating methylphenidate treatment after TBI have focused only on cognitive function reporting improved cognitive function with faster information processing speed and enhanced working memory and attention span (14)(15)(16)(17)(18)(19)(20)(21). A single dose of methylphenidate improved cognitive function and brain functionality compared to placebo in participants suffering from post-TBI symptoms (22,23). Most of these have been short-term studies covering a period between 1 day and 6 weeks and included participants suffering from mild or more severe brain injuries.…”

Pharmacologic Therapies to Promote Recovery of Consciousness

“…38 Few studies have specifically examined the effectiveness of methylphenidate in DoC, with most studies to date assessing post-TBI cognitive or motor function in patients who are without or already emerged from DoC. [39][40][41] Improvements in fatigue, processing speed, attention, and depression have been associated with methylphenidate use in mild-to-moderate acquired brain injury, but whether this therapy can hasten recovery or promote recovery of consciousness compared with placebo remains to be determined. 39,[42][43][44][45] An ongoing phase 1 clinical trial is evaluating the safety of intravenous methylphenidate in patients with severe TBI complicated by DoC (NCT03814356).…”