Impact of Aldehyde Dehydrogenase Activity on Gliomas

Vasilogiannakopoulou, Theodora; Piperi, Christina; Papavassiliou, Athanasios G.

doi:10.1016/j.tips.2018.04.001

Cited by 11 publications

(6 citation statements)

References 10 publications

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Section: St Generation Of Msc Markersmentioning

confidence: 99%

“…ALDH (aldehyde dehydrogenase) belongs to the metabolic enzyme family, which is involved in regulating glycolysis/gluconeogenesis and the detoxification of aldehydes via oxidation [ 180 , 181 ]. It plays an important role in cell survival, proliferation, differentiation, and has been characterized as a classical stem cell marker [ 180 , 181 ]. In human adipose tissues, the ALDH High MSCs represent a more primitive subpopulation than the ALDH Low MSCs, from the perspectives of cell proliferation and tri-differentiation capabilities [ 182 , 183 ].…”

Section: St Generation Of Msc Markersmentioning

confidence: 99%

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Unveiling heterogeneity in MSCs: exploring marker-based strategies for defining MSC subpopulations

Chen,

Liang,

2024

J Transl Med

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Mesenchymal stem/stromal cells (MSCs) represent a heterogeneous cell population distributed throughout various tissues, demonstrating remarkable adaptability to microenvironmental cues and holding immense promise for disease treatment. However, the inherent diversity within MSCs often leads to variability in therapeutic outcomes, posing challenges for clinical applications. To address this heterogeneity, purification of MSC subpopulations through marker-based isolation has emerged as a promising approach to ensure consistent therapeutic efficacy. In this review, we discussed the reported markers of MSCs, encompassing those developed through candidate marker strategies and high-throughput approaches, with the aim of explore viable strategies for addressing the heterogeneity of MSCs and illuminate prospective research directions in this field.

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Section: St Generation Of Msc Markersmentioning

confidence: 99%

Section: St Generation Of Msc Markersmentioning

confidence: 99%

Unveiling heterogeneity in MSCs: exploring marker-based strategies for defining MSC subpopulations

Chen,

Liang,

2024

J Transl Med

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“…However, CD133 has shown to identify only a subset of self-renewing cancer-initiating cells in glioma (12) and CD133 is also expressed in normal neural cells (13), necessitating the evaluation of other CSC markers. Aldehyde dehydrogenase (ALDH) is highly expressed in many malignancies including gliomas and is implicated in increased cell proliferation, maintenance of CSC properties and to negatively impact patient survival (14,15). ALDH isotype ALDH1, specifically ALDH1A, is predominantly found in tumor-initiating cells in gliomas (16).…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells

Surowiec

Ferris

Apfelbaum

et al. 2021

Molecular Cancer Research

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Understanding the cancer stem cell (CSC) landscape in diffuse intrinsic pontine glioma (DIPG) is desperately needed to address treatment resistance and identify novel therapeutic approaches. Patient-derived DIPG cells demonstrated heterogeneous expression of aldehyde dehydrogenase (ALDH) and CD133 by flow cytometry. Transcriptome-level characterization identified elevated mRNA levels of MYC, E2F, DNA damage repair (DDR) genes, glycolytic metabolism, and mTOR signaling in ALDH+ compared with ALDH−, supporting a stem-like phenotype and indicating a druggable target. ALDH+ cells demonstrated increased proliferation, neurosphere formation, and initiated tumors that resulted in decreased survival when orthotopically implanted. Pharmacologic MAPK/PI3K/mTOR targeting downregulated MYC, E2F, and DDR mRNAs and reduced glycolytic metabolism. In vivo PI3K/mTOR targeting inhibited tumor growth in both flank and an ALDH+ orthotopic tumor model likely by reducing cancer stemness. In summary, we describe existence of ALDH+ DIPGs with proliferative properties due to increased metabolism, which may be regulated by the microenvironment and likely contributing to drug resistance and tumor recurrence. Implications: Characterization of ALDH+ DIPGs coupled with targeting MAPK/PI3K/mTOR signaling provides an impetus for molecularly targeted therapy aimed at addressing the CSC phenotype in DIPG.

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“…grade oligoastrocytoma, thereby enhancing our understanding of glioma's cellular and molecular Glioblastoma progression is closely linked to metabolic remodeling in both cancer and immune cells (19,(76)(77)(78), with aerobic glycolysis serving as the primary source of energy and biosynthetic precursors (79). Targeting the Warburg effect is now recognized as a promising therapeutic strategy (18,80). Our study reveals distinct metabolic landscapes and pathway alterations between low-grade and high-grade gliomas, primarily within astrocytes, OPCs, and oligodendrocytes, aligning with histopathological findings (75).…”

Section: Discussionmentioning

confidence: 99%

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Impact of Aldehyde Dehydrogenase Activity on Gliomas

Cited by 11 publications

References 10 publications

Unveiling heterogeneity in MSCs: exploring marker-based strategies for defining MSC subpopulations

Unveiling heterogeneity in MSCs: exploring marker-based strategies for defining MSC subpopulations

Transcriptomic Analysis of Diffuse Intrinsic Pontine Glioma (DIPG) Identifies a Targetable ALDH-Positive Subset of Highly Tumorigenic Cancer Stem-like Cells

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