Quality of life in oropharyngeal cancer: a structured review of the literature

Roets, Evelyne; Tukanova, Karina; Govarts, Anouk; Specenier, Pol

doi:10.1007/s00520-018-4227-9

Cited by 26 publications

(28 citation statements)

References 17 publications

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“…Central to our study was the assumption that disease progression increasingly compromises the patient's physical functioning, leading to worsening mental health and reducing the ability to manage cancer-related issues and emotional distress effectively. In keeping with the literature, we found a negative association between advanced stage and physical functioning [31–33], a strong positive link between physical functioning and mental health [9, 38, 39], and significant relations between mental health and adaptational outcomes [34–36].…”

Section: Discussionsupporting

confidence: 88%

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Biopsychosocial Correlates of Adjustment to Cancer during Chemotherapy: The Key Role of Health-Related Quality of Life

Lauriola

Tomai

2019

The Scientific World Journal

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Background. Patients adjust to cancer in a continuous process that follows the course of the disease. Previous research has considered several illness-related variables and demographics, quality of life, personality, and social factors as predictors of adjustment to cancer, which can be maladaptive (e.g., helplessness-hopelessness and anxious preoccupation) or adaptive (e.g., fighting spirit). Aims. Assuming a biopsychosocial view, we test an empirical model in which disease stage, patient’s age, and gender are viewed as the distal antecedents of positive and negative adjustment to cancer for chemotherapy patients. Health-related quality of life (HRQoL) has a key role, interposing between the distal antecedents and adaptational outcomes. Social support and positive thinking are also included in the model as related to adjustment. Methods. One-hundred-sixty-two consecutive cancer patients receiving adjuvant or standard chemotherapy participated in the study. Patients completed the Mini-Mental Adjustment to Cancer, the Brief-COPE, the Social Provision Scale, and the SF-12 Health Survey. Partial least squares structural equation modeling (PLS-SEM) was applied for model building and hypotheses testing. Results. We found a negative association between advanced stage and physical functioning, a strong positive link between physical functioning and mental health, and significant relations between mental health and helpless-hopelessness, anxious preoccupation, and cognitive avoidance. Social support and positive thinking were related to fighting spirit and fatalism. Cancer stage and female gender were indirectly associated with adaptational outcomes through HRQoL. The patient’s age had no significant relationships in the model. Discussion. HRQoL (both physical and mental) is a key factor for preventing maladjustment in chemotherapy patients. Social support and positive thinking coping style fosters fighting spirit and fatalism on health outcomes. Two potential lines of action seem promising: preventing maladaptive and promoting adaptive adjustments working on patient’s mental health individually and involving significant others in supportive care, respectively.

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Section: Discussionsupporting

confidence: 88%

“…Surprisingly, however, other studies failed to support this relationship [3, 26–29]. With few exceptions [30], an advanced stage is associated with worse quality of life in different types of cancer [31–33].…”

Section: Introductionmentioning

confidence: 99%

Biopsychosocial Correlates of Adjustment to Cancer during Chemotherapy: The Key Role of Health-Related Quality of Life

Lauriola

Tomai

2019

The Scientific World Journal

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“…In the last decade, intensity-modulated radiotherapy (IMRT) has become standard of care for patients with head and neck cancer (HNC). Although associated with less acute xerostomia and an improved quality of life (QOL) as compared to conventional radiotherapy, 1,2 IMRT unfortunately still significantly impacts QOL via acute and late toxicity. [3][4][5] Long-term HNC survivors especially are significantly affected by late toxicities 6,7 ; yet the data on very late toxicity (VLT) (≥3 years after radiotherapy) remains sparse.…”

Section: Introductionmentioning

confidence: 99%

Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy

et al. 2019

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Background Acute and late toxicity after intensity‐modulated radiotherapy (IMRT) for head and neck cancer (HNC) impacts on patient quality of life; yet, very late toxicity data remain scarce. This study assessed dysphagia, xerostomia, and neck fibrosis 3‐8 years after IMRT. Methods A retrospective analysis using generalized estimated equations was performed on 60 patients with HNC treated with fractionated IMRT between 2000 and 2015 who had a follow‐up ≥8 years. Toxicity was scored using LENT‐SOMA scales. Results A trend towards a nonlinear global time effect (P = .05) was noted for dysphagia with a decrease during the 5 years post‐treatment and an increase thereafter. A significant decrease in xerostomia (P = .001) and an increase in neck fibrosis (P = .04) was observed until 8 years. Conclusions Dysphagia, xerostomia, and neck fibrosis do not appear stable over time and remain highly prevalent in the very late follow‐up. Our findings support the need for prospective trials investigating very late toxicity in patients with HNC.

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“…In accordance with your recommendation, we extended our systematic review by using the Cochrane Central database. This resulted in two additionally included articles [1,2]. After analyzing these articles, we still believe that the conclusions of our review remain valid.…”

Section: Dear Miriam Allein Zago Marcolino and Rafaela Soares Rechmentioning

confidence: 87%

“…We thank you for your valuable comments on our structured review [1]. Oropharyngeal cancer is associated with significant morbidity and Quality of Life (QoL) analysis is of extreme importance in this patient group.…”

Section: Dear Miriam Allein Zago Marcolino and Rafaela Soares Rechmentioning

confidence: 99%

Authors’ response letter: Quality of life in oropharyngeal cancer: a structured review of the literature

Roets

Tukanova

Govarts

et al. 2019

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Quality of life in oropharyngeal cancer: a structured review of the literature

Cited by 26 publications

References 17 publications

Biopsychosocial Correlates of Adjustment to Cancer during Chemotherapy: The Key Role of Health-Related Quality of Life

Biopsychosocial Correlates of Adjustment to Cancer during Chemotherapy: The Key Role of Health-Related Quality of Life

Very late xerostomia, dysphagia, and neck fibrosis after head and neck radiotherapy

Authors’ response letter: Quality of life in oropharyngeal cancer: a structured review of the literature

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