Beta and Gamma Oscillations in Prefrontal Cortex During NMDA Hypofunction: An In Vitro Model of Schizophrenia Features

Rebollo, Beatriz; Pérez-Zabalza, María; Ruiz-Mejias, Marcel; Perez-Mendez, Lorena; Sánchez-Vives, María V.

doi:10.1016/j.neuroscience.2018.04.035

Cited by 19 publications

(16 citation statements)

References 92 publications

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“…These studies in acute brain slices have revealed that oscillatory population activity could be generated by isolated local circuits. Therefore, these studies justify the use of brain slices as an experimental approach for investigation of oscillations that resemble the in vivo rhythmic activity ( Whittington et al, 1995 , 1997 ; Cunningham et al, 2003 ; McNally, 2013 ; Rebollo et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…With regards to the glutamatergic system, inhibition of NMDA receptor function induces aberrant high frequency oscillations throughout cortical and subcortical networks ( Pinault, 2008 ; Rebollo et al, 2018 ). Our Rac1 cKO mice display impaired synaptic transmission and NMDA-dependent LTP, reduced gamma frequency range (30–80 Hz) and induced aberrant high gamma frequency oscillations (80–150 Hz) in the cortex.…”

Section: Discussionmentioning

confidence: 99%

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Mice With Decreased Number of Interneurons Exhibit Aberrant Spontaneous and Oscillatory Activity in the Cortex

Kalemaki

Konstantoudaki

Tivodar

et al. 2018

Front. Neural Circuits

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GABAergic (γ-aminobutyric acid) neurons are inhibitory neurons and protect neural tissue from excessive excitation. Cortical GABAergic neurons play a pivotal role for the generation of synchronized cortical network oscillations. Imbalance between excitatory and inhibitory mechanisms underlies many neuropsychiatric disorders and is correlated with abnormalities in oscillatory activity, especially in the gamma frequency range (30–80 Hz). We investigated the functional changes in cortical network activity in response to developmentally reduced inhibition in the adult mouse barrel cortex (BC). We used a mouse model that displays ∼50% fewer cortical interneurons due to the loss of Rac1 protein from Nkx2.1/Cre-expressing cells [Rac1 conditional knockout (cKO) mice], to examine how this developmental loss of cortical interneurons may affect basal synaptic transmission, synaptic plasticity, spontaneous activity, and neuronal oscillations in the adult BC. The decrease in the number of interneurons increased basal synaptic transmission, as examined by recording field excitatory postsynaptic potentials (fEPSPs) from layer II networks in the Rac1 cKO mouse cortex, decreased long-term potentiation (LTP) in response to tetanic stimulation but did not alter the pair-pulse ratio (PPR). Furthermore, under spontaneous recording conditions, Rac1 cKO brain slices exhibit enhanced sensitivity and susceptibility to emergent spontaneous activity. We also find that this developmental decrease in the number of cortical interneurons results in local neuronal networks with alterations in neuronal oscillations, exhibiting decreased power in low frequencies (delta, theta, alpha) and gamma frequency range (30–80 Hz) with an extra aberrant peak in high gamma frequency range (80–150 Hz). Therefore, our data show that disruption in GABAergic inhibition alters synaptic properties and plasticity, while it additionally disrupts the cortical neuronal synchronization in the adult BC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mice With Decreased Number of Interneurons Exhibit Aberrant Spontaneous and Oscillatory Activity in the Cortex

Kalemaki

Konstantoudaki

Tivodar

et al. 2018

Front. Neural Circuits

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“…It has gained increasing interest as a result of recent studies on the role of the dorsal FC in top-down cognitive control of sensory processing (Fritz et al 2010;Francis et al 2018;Bimbard et al 2018;Elgueda et al 2019), in goal-directed behavior (Zhou et al 2016), in the interactions in the frontoparietal attention network (Sellers et al 2016), and as a model system to study the effects of anesthesia (Sellers et al 2013(Sellers et al , 2015Wollstadt et al 2017). Moreover, in vitro studies of FC functional microcircuitry have also been carried out in the ferret (Krimer and Goldman-Rakic 2001;McCormick et al 2003;Shu et al 2006Shu et al , 2007Wang et al 2006;Winograd et al 2008) and have been recently developed as an in vitro model of schizophrenia (Rebollo et al 2018). However, there have hitherto been few neuroanatomical studies of the ferret FC to keep pace with advances in neurophysiological research.…”

Section: Introductionmentioning

confidence: 99%

Dorsal prefrontal and premotor cortex of the ferret as defined by distinctive patterns of thalamo-cortical projections

et al. 2020

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Recent studies of the neurobiology of the dorsal frontal cortex (FC) of the ferret have illuminated its key role in the attention network, top-down cognitive control of sensory processing, and goal directed behavior. To elucidate the neuroanatomical regions of the dorsal FC, and delineate the boundary between premotor cortex (PMC) and dorsal prefrontal cortex (dPFC), we placed retrograde tracers in adult ferret dorsal FC anterior to primary motor cortex and analyzed thalamo-cortical connectivity. Cyto-and myeloarchitectural differences across dorsal FC and the distinctive projection patterns from thalamic nuclei, especially from the subnuclei of the medial dorsal (MD) nucleus and the ventral thalamic nuclear group, make it possible to clearly differentiate three separate dorsal FC fields anterior to primary motor cortex: polar dPFC (dPFCpol), dPFC, and PMC. Based on the thalamic connectivity, there is a striking similarity of the ferret's dorsal FC fields with other species. This possible homology opens up new questions for future comparative neuroanatomical and functional studies.

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“…However, we found that when NMDA input to the local network is decreased during in vitro Up and Down states, beta-gamma rhythm (15-90 Hz) is also increased, showing a hypersynchronization of fast rhythms. This suggests that NMDAR activation prevents hypersynchronization under physiological conditions [114]. Reduction of firing rates in the local network is most often associated with a decrease in the synchronization in the beta-gamma range in several cases; for example, cortical inhibitory alteration and overinhibition in a Down syndrome model [83], increased functional connectivity in a Williams-Beuren syndrome model [115], when comparing area-specific cortical activity [17], or even by the effect of temperature modulation [116].…”

Section: What Is the Relationship Between Network Firing Rate And Gammentioning

confidence: 87%

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2020

OBM Geriatrics

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The present article summarizes the current state of understanding in geriatric cardiology in terms of the main developments in the field. The focus of the present review is on the therapeutics, into the specific characteristics of the elderly patients dealing with the prevention of arterial hypertension, bradycardic arrhythmias, atrial fibrillation, coronary artery syndromes, valve heart diseases, and heart failure. Progress in the field of medicine has rendered possible to treat lethal cardiac diseases in the extremely old patients. Nonetheless, data regarding the very old cardiac patients are limited, and it is dangerous to directly extrapolate the experience with the young patients to the old ones. • Preventive therapies are important in the old cardiac patients, although these therapies differ from those for young patients. • Very old patients with arterial hypertension benefit from antihypertensive treatment, although the therapeutic strategy of one-size-fits-all cannot be applied. • Elderly patients often require a cardiac pacemaker. In the case of patients with sinus node dysfunction, pacing modes capable of preserving atrioventricular synchrony are associated with a reduced incidence of atrial fibrillation. In the case of patients with atrioventricular block, the importance of synchronization is debatable. Implantable cardioverter-defibrillators may be used in very old patients, although a limited number of Keywords Geriatric cardiology; old cardiac patients; geriatric cardiac diseases

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Beta and Gamma Oscillations in Prefrontal Cortex During NMDA Hypofunction: An In Vitro Model of Schizophrenia Features

Cited by 19 publications

References 92 publications

Mice With Decreased Number of Interneurons Exhibit Aberrant Spontaneous and Oscillatory Activity in the Cortex

Mice With Decreased Number of Interneurons Exhibit Aberrant Spontaneous and Oscillatory Activity in the Cortex

Dorsal prefrontal and premotor cortex of the ferret as defined by distinctive patterns of thalamo-cortical projections

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